NCT03513653

Brief Summary

STRATS-AHF (STrain for Risk Assessment and Therapeutic Strategies in patients with Acute Heart Failure) registry enrolled 4,312 patients hospitalized for acute HF from 3 tertiary university hospitals (Seoul National University Bundang Hospital, Seoul National University Hospital, and Chungnam National University Hospital) from January 2009 through December 2016.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
4,312

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Jan 2009

Longer than P75 for all trials

Geographic Reach
1 country

3 active sites

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2009

Completed
8.7 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 5, 2017

Completed
8 months until next milestone

First Submitted

Initial submission to the registry

April 19, 2018

Completed
12 days until next milestone

First Posted

Study publicly available on registry

May 1, 2018

Completed
5.7 years until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2023

Completed
Last Updated

April 12, 2023

Status Verified

April 1, 2023

Enrollment Period

8.7 years

First QC Date

April 19, 2018

Last Update Submit

April 11, 2023

Conditions

Heart Failure AcuteHeart FailureEchocardiography

Keywords

acute heart failureglobal longitudinal strainejection fractionechocardiographymortality

Outcome Measures

Primary Outcomes (1)

  • All-cause mortality

    Death from any cause

    up to 5 years

Secondary Outcomes (3)

  • Hospitalization for heart failure

    up to 5 years

  • Composite of all-cause mortality and hospitalization for heart failure

    up to 5 years

  • Ischemic stroke

    up to 5 years

Study Arms (1)

Acute heart failure

Patients hospitalized for acute heart failure and underwent echocardiography with speckle-tracking imaging

Diagnostic Test: Echocardiography with speckle-tracking imaging

Interventions

Echocardiography with speckle-tracking imagingDIAGNOSTIC_TEST

1. Measurement of left ventricular ejection fraction and global longitudinal strain 2. Measurement of left atrial reservoir strain (peak atrial longitudinal strain) 3. Measurement of right ventricular global longitudinal strain

Acute heart failure

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

Patients hospitalized for acute heart failure

You may qualify if:

  • Patients with signs or symptoms of HF and either lung congestion, or objective findings of LV systolic dysfunction or structural heart disease

You may not qualify if:

  • Patients who presented with acute coronary syndrome

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (3)

Seoul National University Bundang Hospital

Seongnam-si, Gyeonggi-do, 13620, South Korea

Location

Chungnam National University Hospital

Daejeon, 35015, South Korea

Location

Seoul National University Hospital

Seoul, 03080, South Korea

Location

Related Publications (11)

  • Park JJ, Park JB, Park JH, Cho GY. Global Longitudinal Strain to Predict Mortality in Patients With Acute Heart Failure. J Am Coll Cardiol. 2018 May 8;71(18):1947-1957. doi: 10.1016/j.jacc.2018.02.064.

    PMID: 29724346BACKGROUND

  • Park JH, Park JJ, Park JB, Cho GY. Prognostic Value of Biventricular Strain in Risk Stratifying in Patients With Acute Heart Failure. J Am Heart Assoc. 2018 Oct 2;7(19):e009331. doi: 10.1161/JAHA.118.009331.

    PMID: 30371332BACKGROUND

  • Hwang IC, Cho GY, Choi HM, Yoon YE, Park JJ, Park JB, Park JH, Lee SP, Kim HK, Kim YJ, Sohn DW. Derivation and validation of a mortality risk prediction model using global longitudinal strain in patients with acute heart failure. Eur Heart J Cardiovasc Imaging. 2020 Dec 1;21(12):1412-1420. doi: 10.1093/ehjci/jez300.

    PMID: 31819981BACKGROUND

  • Park JJ, Choi HM, Hwang IC, Park JB, Park JH, Cho GY. Myocardial Strain for Identification of beta-Blocker Responders in Heart Failure with Preserved Ejection Fraction. J Am Soc Echocardiogr. 2019 Nov;32(11):1462-1469.e8. doi: 10.1016/j.echo.2019.06.017. Epub 2019 Sep 17.

    PMID: 31540679BACKGROUND

  • Park JH, Hwang IC, Park JJ, Park JB, Cho GY. Prognostic power of left atrial strain in patients with acute heart failure. Eur Heart J Cardiovasc Imaging. 2021 Jan 22;22(2):210-219. doi: 10.1093/ehjci/jeaa013.

    PMID: 32031588BACKGROUND

  • Park CS, Park JB, Park JJ, Park JH, Cho GY. Impact of sex and myocardial function on association of obesity with mortality in Asian patients with acute heart failure: a retrospective analysis from the STRATS-AHF registry. BMJ Open. 2020 Feb 10;10(2):e031608. doi: 10.1136/bmjopen-2019-031608.

    PMID: 32047009BACKGROUND

  • Park JJ, Mebazaa A, Hwang IC, Park JB, Park JH, Cho GY. Phenotyping Heart Failure According to the Longitudinal Ejection Fraction Change: Myocardial Strain, Predictors, and Outcomes. J Am Heart Assoc. 2020 Jun 16;9(12):e015009. doi: 10.1161/JAHA.119.015009. Epub 2020 Jun 10.

    PMID: 32519555BACKGROUND

  • Park JJ, Park JH, Hwang IC, Park JB, Cho GY, Marwick TH. Left Atrial Strain as a Predictor of New-Onset Atrial Fibrillation in Patients With Heart Failure. JACC Cardiovasc Imaging. 2020 Oct;13(10):2071-2081. doi: 10.1016/j.jcmg.2020.04.031. Epub 2020 Jul 15.

    PMID: 32682715BACKGROUND

  • Park JH, Kim M, Park JJ, Park JB, Cho GY. Prognostic Role of RVGLS/PASP Ratio, a New Echocardiographic Parameter of the Right Ventricle-Pulmonary Artery Coupling, in Patients With Acute Heart Failure. Int J Heart Fail. 2024 Oct 28;6(4):165-173. doi: 10.36628/ijhf.2024.0048. eCollection 2024 Oct.

    PMID: 39513018DERIVED

  • Park CS, Park JJ, Hwang IC, Park JB, Park JH, Cho GY. Myocardial strain to identify benefit from beta-blockers in patients with heart failure with reduced ejection fraction. ESC Heart Fail. 2022 Apr;9(2):1248-1257. doi: 10.1002/ehf2.13800. Epub 2022 Jan 9.

    PMID: 35001562DERIVED

  • Park CS, Hwang IC, Park JJ, Park JH, Park JB, Cho GY. Determinants of the survival benefit associated with statins in patients with acute heart failure. ESC Heart Fail. 2021 Dec;8(6):5424-5435. doi: 10.1002/ehf2.13637. Epub 2021 Oct 5.

    PMID: 34612019DERIVED

MeSH Terms

Conditions

Heart Failure

Interventions

Echocardiography

Condition Hierarchy (Ancestors)

Heart DiseasesCardiovascular Diseases

Intervention Hierarchy (Ancestors)

Cardiac Imaging TechniquesDiagnostic ImagingDiagnostic Techniques and ProceduresDiagnosisUltrasonographyHeart Function TestsDiagnostic Techniques, Cardiovascular

Study Officials

  • Goo-Yeong Cho, MD, PhD

    Seoul National University Bundang Hospital

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
RETROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor

Study Record Dates

First Submitted

April 19, 2018

First Posted

May 1, 2018

Study Start

January 1, 2009

Primary Completion

September 5, 2017

Study Completion

December 31, 2023

Last Updated

April 12, 2023

Record last verified: 2023-04

Locations

KR(3)