The Value of Memory B Cells Marker (CD27) and Howell Jelly Bodies Detrection in Critically Ill Patients

NCT02108405 | Completed DMC

• 1 other identifier: 1020/02/13
• Study Type: observational
• Target: 96
• Locations: 1 country
• Sites: 1

Brief Summary

A total of ninety - five patients (54men and 41women) were included in the study. Fifty-eight patients developed septic complication during ICU stay (sepsis group). Forty seven patients were critically ill without evidence of infectious organism (SIRS group). At admission, Patients data include clinical status; SOFA score; central venous pressure; laboratory analysis and arterial blood gas analysis were measured. Routine cultures were obtained. The attending physician evaluated the patients for sepsis, severe sepsis, or septic shock as long as their stay in ICU. Memory B cells and Heinz bodies were monitored.

Conditions

Sepsis

Keywords

critically ill patient.

Outcome Measures

Primary Outcomes (1)

• Memory B cells

  Memory B cells detection was made using flowcytometry.

  1 day (At time of ICU admission)

Secondary Outcomes (1)

• Heinz bodies

  1 day (At ICU admission)

Study Arms (2)

Sepsis

Sepsis Forty eight patients developed septic complication during ICU stay (sepsis group).

SIRS group

SIRS group Forty seven patients were critically ill without evidence of infectious organism (SIRS group).

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

A total of ninety five patients were included in the study. fifty eight patients developed septic complication during ICU stay (sepsis group). fifty seven patients were critically ill without evidence of infectious organism (SIRS group). At admission, the patient's age, sex, height and weight were recorded.

You may qualify if:

• Critically ill patients with manifestation of sepsis or SIRS

You may not qualify if:

• Patients received anti-inflammatory drugs or corticosteroids before admission, who had immunosuppressive illness, who had chronic organ failure; who had received massive blood transfusion; those with radiation therapy, previous organ transplantation were excluded from the study.

Sponsors & Collaborators

• Tanta University: lead

Study Sites (1)

Tanta University

Tanta, Algharbyia, 35217, Egypt

Location

MeSH Terms

Conditions

Sepsis

Condition Hierarchy (Ancestors)

Infections; Systemic Inflammatory Response Syndrome; Inflammation; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Ayman A Yousef, MD

  Assistant Professor

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant professor

Study Record Dates

• First Submitted: March 1, 2013
• First Posted: April 9, 2014
• Study Start: May 1, 2013
• Primary Completion: January 1, 2014
• Study Completion: January 1, 2014
• Last Updated: April 9, 2014

Record last verified: 2014-04

Locations

EG (1)