NCT03506087

Brief Summary

This project will develop and test a model intervention for Advance Care Planning (ACP) for patients with advanced chronic kidney disease (CKD) cared for in nephrology clinics that have the capacity to consult with or refer to palliative care. Specifically, we will compare the effectiveness of having a trained ACP coach meet in person with patients to discuss their goals and preferences vs. providing patients with a packet of material to review on their own and then discuss with their nephrologist at their initiation. Hypothesis: In patients aged 55 or older with stage 3-5 Chronic Kidney Disease cared for in a CKD outpatient clinic, an advance care planning process that involves in-person meetings with a trained ACP coach will be more effective than providing patients with printed educational materials alone.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
288

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started May 2018

Typical duration for not_applicable

Geographic Reach
1 country

4 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

April 13, 2018

Completed
10 days until next milestone

First Posted

Study publicly available on registry

April 23, 2018

Completed
22 days until next milestone

Study Start

First participant enrolled

May 15, 2018

Completed
1.5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 28, 2019

Completed
5 months until next milestone

Study Completion

Last participant's last visit for all outcomes

March 31, 2020

Completed
Last Updated

July 9, 2020

Status Verified

July 1, 2020

Enrollment Period

1.5 years

First QC Date

April 13, 2018

Last Update Submit

July 8, 2020

Conditions

Keywords

Advance Care PlanningShared Decision Making

Outcome Measures

Primary Outcomes (2)

  • Advance directive in EHR

    Proportion of participants with advance directive or POLST/MOLST in EHR

    16 weeks after baseline

  • ACP readiness score

    Mean ACP readiness score at follow-up survey

    14 weeks after baseline

Secondary Outcomes (2)

  • Medical decision maker documented in EHR

    16 weeks after baseline

  • ACP conversation with nephrologist documented in EHR

    16 weeks after baseline

Study Arms (2)

Coaching

EXPERIMENTAL

Receives printed advance care planning (ACP) materials. Receives advance care planning coaching session. May receive followup coaching session, typically by telephone.

Behavioral: Advance care planning coaching session.Behavioral: Printed advance care planning materials

Enhanced Control

ACTIVE COMPARATOR

Receives printed advance care planning materials only.

Behavioral: Printed advance care planning materials

Interventions

A 60-minute in-person coaching session. The advance care planning coach, trained in motivational interviewing, will use a flexible script and checklist to assess the participant's readiness to engage in advance care planning and guide the participant forward in the process, proceeding at the participant's pace. Some participants may complete advance directives while others will not get that far. Some participants may receive a follow-up session 2-4 weeks later. Typically this 20 to 30-minute conversation will be by phone, but it may be conducted at the clinic as indicated for the participant.

Coaching

Participants are provided with a folder containing an advance care planning guide developed by the Coalition for the Supportive Care of Kidney Patients for persons with Chronic Kidney Disease. The patient folder also contains the advance directive form used by the clinic that is appropriate to the state.

CoachingEnhanced Control

Eligibility Criteria

Age55 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Chronic Kidney Disease (CKD) Stage 3-5
  • Age 55 or older
  • English speaking
  • Patient at participating CKD clinic

You may not qualify if:

  • Receiving dialysis
  • Kidney transplant recipient
  • Cognitively impaired or otherwise not competent to participate (as deemed by treating nephrologist and research staff)
  • Participation contra-indicated for patient's health (as deemed by treating nephrologist)

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (4)

MedStar Washington Hospital Center

Washington D.C., District of Columbia, 20010, United States

Location

Renal & Transplant Associates of New England

Springfield, Massachusetts, 01107, United States

Location

Mountain Kidney & Hypertension Associates

Asheville, North Carolina, 28801, United States

Location

University of Pittsburgh Medical Center Kidney Clinic

Pittsburgh, Pennsylvania, 15213, United States

Location

Related Publications (1)

  • Lupu DE, Aldous A, Anderson E, Schell JO, Groninger H, Sherman MJ, Aiello JR, Simmens SJ. Advance Care Planning Coaching in CKD Clinics: A Pragmatic Randomized Clinical Trial. Am J Kidney Dis. 2022 May;79(5):699-708.e1. doi: 10.1053/j.ajkd.2021.08.019. Epub 2021 Oct 12.

MeSH Terms

Conditions

Renal Insufficiency, Chronic

Condition Hierarchy (Ancestors)

Renal InsufficiencyKidney DiseasesUrologic DiseasesFemale Urogenital DiseasesFemale Urogenital Diseases and Pregnancy ComplicationsUrogenital DiseasesMale Urogenital DiseasesChronic DiseaseDisease AttributesPathologic ProcessesPathological Conditions, Signs and Symptoms

Study Officials

  • Dale E Lupu, PhD, MPH

    The George Washington University

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
SUPPORTIVE CARE
Intervention Model
PARALLEL
Model Details: Participants will be randomized 1:1 to an intervention arm or an enhanced control arm. Participants in the intervention group will receive printed educational materials plus one or more ACP coaching sessions. Participants in the enhanced control arm will receive printed materials only.
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Associate Research Professor

Study Record Dates

First Submitted

April 13, 2018

First Posted

April 23, 2018

Study Start

May 15, 2018

Primary Completion

October 28, 2019

Study Completion

March 31, 2020

Last Updated

July 9, 2020

Record last verified: 2020-07

Data Sharing

IPD Sharing
Will not share

Locations