Neopterin Dosage in the Eye
CHA
Appreciation of the Possibility of Dosing Neopterin in Eye Liquids. Pilot Study of Neopterin Dosage in Eye Liquids.
2 other identifiers
observational
20
1 country
1
Brief Summary
The purpose of the study is to determine whether neopterin can be dosed in the fluid of the eye's anterior chamber for patient with non-inflammatory and non-infectious ophthalmic pathology.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for all trials
Started Jun 2018
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
April 6, 2018
CompletedFirst Posted
Study publicly available on registry
April 13, 2018
CompletedStudy Start
First participant enrolled
June 22, 2018
CompletedPrimary Completion
Last participant's last visit for primary outcome
January 25, 2019
CompletedStudy Completion
Last participant's last visit for all outcomes
January 25, 2019
CompletedOctober 26, 2022
October 1, 2022
7 months
April 6, 2018
October 24, 2022
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Detection and dosage of neopterin in the eye
HCL will detect and dose the neopterin in the eye's anterior chamber fluid
3 month
Secondary Outcomes (2)
Neopterin concentration comparison between study values and reference value.
3 month
False positives identification and elimination.
3 month
Study Arms (1)
Neopterin Dosage
Eye's anterior chamber fluid and urines are sampled for posterior neopterin analysis
Interventions
Eye's anterior chamber fluid and urines are sampled for posterior neopterin analysis
Eligibility Criteria
Patient eligible for non infectious and non inflammatory eye surgery
You may qualify if:
- Age ≥ 18 years-old
- Non inflammatory or non infectious ophthalmic pathology requiring puncture of eye's anterior chamber fluid.
- Minimum of 200 microliter sample
- Immunocompetent subjects
- Signed and dated informed consent
- Samples management in accordance with the pre-analytical conditions specified in the protocol
- Age \< 18 years-old
You may not qualify if:
- Subjects who exercised his right of withdrawal
- Study suspended on principal investigator, sponsor or health authorities' demand.
- Deceased subjects
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Centre Hospitalier Intercommunal Toulon La Seyne sur Mer
Toulon, Var, 83200, France
Related Publications (1)
Kuvbachieva-Benarrosh A, Nefzaoui C, Quadrio I, Remignon CH, Jullian E, Perret-Liaudet A. Neopterin level can be measured by intraocular liquid biopsy. Clin Chem Lab Med. 2022 Oct 14;61(1):e20-e21. doi: 10.1515/cclm-2022-0691. Print 2023 Jan 27. No abstract available.
PMID: 36227583RESULT
Biospecimen
eye's anterior chamber fluid
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Chaker Nefzaoui, doctor
Centre Hospitalier Intercommunal Toulon La Seyne sur Mer
- STUDY CHAIR
Anélia Benarrosh, doctor
Centre Hospitalier Intercommunal Toulon La Seyne sur Mer
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
April 6, 2018
First Posted
April 13, 2018
Study Start
June 22, 2018
Primary Completion
January 25, 2019
Study Completion
January 25, 2019
Last Updated
October 26, 2022
Record last verified: 2022-10
Data Sharing
- IPD Sharing
- Will not share
no plan