The Role of Music Stimulation in Disorders of Consciousness State: an fMRI Study

NCT03492294 | Completed DMC

• 1 other identifier: 2008W1224
• Study Type: observational
• Target: 11
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of the present study was to evaluated the neural effect of music on the cerebral activation in unresponsive wakefulness syndrome (UWS) and minimally conscious state (MCS) by using functional magnetic resonance imaging (fMRI).

Conditions

Vegetative State; Minimally Conscious State

Keywords

disorders of consciousness; music stimulation; functional magnetic resonance imaging

Outcome Measures

Primary Outcomes (1)

• Coma Recovery Scale-Revised

  examine the prognostic value of these patients, longitudinal behavioral assessments were repeatedly conducted by means of the CRS-R after fMRI acquisition

  one to two years

Study Arms (1)

patients with disorders of consciousness

patients with disorders of consciousness from several brain injury have been clinically classified into coma, unresponsive wakefulness syndrome and minimally conscious state. These patients were scaned by functional magnetic resonance imaging.

Diagnostic Test: functional magnetic resonance imaging

Interventions

functional magnetic resonance imaging DIAGNOSTIC_TEST

Patients with disorders of consciousness were assessed by functional magnetic resonance imaging while they were exposed under the condition of music.

Also known as: Coma Recovery Scale-Revised

patients with disorders of consciousness

Eligibility Criteria

• Age: 21 Years - 61 Years
• Sex: all
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

patients with disorders of consciousness

You may qualify if:

• age ≥ 18 years old;
• no administration of neuromuscular blockers or sedation within the 24 hours of enrolment;
• brain damage with eye opening (indicating wakefulness and rest cycles)

You may not qualify if:

• Coma;
• neurodegenerative disease;
• psychiatric or neurologic illness;
• with intracranial metal or other body metal.

Sponsors & Collaborators

• Hangzhou Normal University: lead

Study Sites (1)

International Vegetative State and Consciousness Science Institute, Hangzhou Normal University

Hangzhou, Zhejiang, 3100036, China

Location

Related Publications (1)

• Owen AM, Coleman MR. Detecting awareness in the vegetative state. Ann N Y Acad Sci. 2008;1129:130-8. doi: 10.1196/annals.1417.018.

  PMID: 18591475 BACKGROUND

MeSH Terms

Conditions

Persistent Vegetative State; Consciousness Disorders

Interventions

Magnetic Resonance Imaging

Condition Hierarchy (Ancestors)

Brain Damage, Chronic; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Unconsciousness; Neurobehavioral Manifestations; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Neurocognitive Disorders; Mental Disorders

Intervention Hierarchy (Ancestors)

Tomography; Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis

Study Officials

• Haibo Di, Pro

  International Vegetative State and Consciousness Science Institute, Hangzhou Normal University

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dr

Study Record Dates

• First Submitted: April 3, 2018
• First Posted: April 10, 2018
• Study Start: December 1, 2008
• Primary Completion: November 1, 2017
• Study Completion: April 1, 2018
• Last Updated: April 10, 2018

Record last verified: 2018-04

Data Sharing

• IPD Sharing: Will share

Locations

CN (1)