Trials Sponsors Conditions Drugs Pricing

Conditions

Alpha 1-Antitrypsin Deficiency Asthma Bronchiectasis Bronchopulmonary Dysplasia Chronic Obstructive Pulmonary Disease Emphysema Pulmonary Fibrosis Sarcoidosis, Pulmonary

Keywords

magnetic resonance imaginghyperpolarized xenon-129lung functionlung structure

Outcome Measures

Primary Outcomes (2)

Ventilation Defect Percent (VDP)
Whole lung and lobe specific ventilation defect percent (VDP) measured from 129Xe static ventilation magnetic resonance images.
1-5 years
Apparent Diffusion Coefficient (ADC)
Whole lung and lobe specific apparent diffusion coefficient (ADC) measured from 129Xe diffusion-weighted magnetic resonance images.
1-5 years

Secondary Outcomes (1)

Signal-to-noise ratio (SNR)
1-5 years

Study Arms (1)

Patients with and without lung disease

EXPERIMENTAL

All enrolled patients will undergo pulmonary function testing, questionnaires, 1H MRI, static ventilation and/or diffusion-weighted hyperpolarized 129Xe MRI and sputum induction at one or more timepoints over five years.

Other: Hyperpolarized 129Xe MRI

Interventions

Hyperpolarized 129Xe MRIOther

Magnetic resonance imaging (MRI) using inhaled hyperpolarized 129Xe gas is a research approach for the non-invasive visualization and measurement of lung structure and function.

Patients with and without lung disease

Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.

Eligibility Criteria

Age18 Years - 85 Years

Sexall

Healthy VolunteersYes

Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

Male or female aged 18-85 years with diagnosed lung disease including but not limited to: asthma, emphysema, COPD, bronchiectasis, sarcoidosis, pulmonary fibrosis, alpha 1-anti-trypsin deficiency, eosinophilic granulomatosis with polyangiitis and bronchopulmonary dysplasia.
Subject understands the study procedures and is willing to participate in the study as indicated by the signature on the informed consent

Sponsors & Collaborators

St. Joseph's Healthcare Hamilton
Othercollaborator
McMaster University
Otherlead

Study Sites (1)

Firestone Institute for Respiratory Health, St. Joseph's Healthcare

Hamilton, Ontario, L8N 4A6, Canada

RECRUITING

Sarah Svenningsen, PhDCONTACT905-522-1155 ext. 37313 svennins@mcmaster.ca

Related Publications (10)

Kirby M, Heydarian M, Svenningsen S, Wheatley A, McCormack DG, Etemad-Rezai R, Parraga G. Hyperpolarized 3He magnetic resonance functional imaging semiautomated segmentation. Acad Radiol. 2012 Feb;19(2):141-52. doi: 10.1016/j.acra.2011.10.007. Epub 2011 Nov 21.
PMID: 22104288BACKGROUND
Kirby M, Svenningsen S, Kanhere N, Owrangi A, Wheatley A, Coxson HO, Santyr GE, Paterson NA, McCormack DG, Parraga G. Pulmonary ventilation visualized using hyperpolarized helium-3 and xenon-129 magnetic resonance imaging: differences in COPD and relationship to emphysema. J Appl Physiol (1985). 2013 Mar 15;114(6):707-15. doi: 10.1152/japplphysiol.01206.2012. Epub 2012 Dec 13.
PMID: 23239874BACKGROUND

MeSH Terms

Conditions

AsthmaPulmonary Disease, Chronic ObstructiveBronchiectasisEmphysemaPulmonary FibrosisBronchopulmonary Dysplasiaalpha 1-Antitrypsin DeficiencySarcoidosis, Pulmonary

Condition Hierarchy (Ancestors)

Bronchial DiseasesRespiratory Tract DiseasesLung Diseases, ObstructiveLung DiseasesRespiratory HypersensitivityHypersensitivity, ImmediateHypersensitivity

Study Officials

Parameswaran Nair, MD, PhD
McMaster University
PRINCIPAL INVESTIGATOR

Central Study Contacts

Sarah Svenningsen, PhD

CONTACT

(905) 522-1155 svennins@mcmaster.ca

Melanie Kjarsgaard, RRT

CONTACT

(905) 522-1155

Study Design

Study Type: interventional
Phase: not applicable
Allocation: NA
Masking: NONE
Purpose: BASIC SCIENCE
Intervention Model: SINGLE GROUP
Sponsor Type: OTHER
Responsible Party: PRINCIPAL INVESTIGATOR
PI Title: Professor of Medicine

Study Record Dates

First Submitted

February 28, 2018

First Posted

March 6, 2018

Study Start

April 19, 2018

Actual (reported)

Primary Completion

October 2024

Estimated (date passed)

Exploring the Utility of Hyperpolarized 129Xe MRI in Healthy Volunteers and Patients With Lung Disease

Brief Summary

Registry Overview

Trial Relationships

Study Timeline

First Submitted

First Posted

Study Start

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (2)

Secondary Outcomes (1)

Study Arms (1)

Patients with and without lung disease

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

Related Publications (10)

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Study Officials

Central Study Contacts

Study Design

Study Record Dates

You may not qualify if:

Data Sharing

Source record

Locations

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

First Submitted

First Posted

Study Start

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (2)

Secondary Outcomes (1)

Study Arms (1)

Patients with and without lung disease

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

Related Publications (10)

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Study Officials

Central Study Contacts

Study Design

Study Record Dates

You may not qualify if:

Data Sharing

Source record

Locations