NCT03452787|Completed
Epigenomic and Metabolomic Signatures of APOA2 Gene by Saturated Fat Interaction
Meta Analysis of Epigenomic and Metabolomic Signatures of APOA2 Gene by Saturated Fat
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Meta Analysis of Epigenomic and Metabolomic Signatures of APOA2 Gene by Saturated Fat
Sponsor study identifier
observational
602
1 country
1
Study Start
January 1, 2017
Actual (reported)Primary Completion
December 1, 2017
Actual (reported)Study Completion
December 31, 2017
Actual (reported)Obesity is driven by genetic and environmental factors. Among the latter, diet is a most important one. The investigators refer to these combinations of genetic and dietary factors as 'gene-diet interactions.' Higher consumption of saturated fats (found mostly in foods of animal origin) has been associated with higher weight in people who were homozygotes for the minor allele at a genetic variant known as APOA2 -265 T\>C (rs5082). In the current study, the investigators will seek to gain an understanding of the biological mechanisms driving this interaction. The investigators will select participants in three cohorts according to this genetic factor and conduct a series of molecular analyses (epigenetics, transcriptomics, and metabolomics). The analyses will identify epigenetic marks that are associated with saturated fat intake exclusively in subjects who carry this genetic factor. Moreover, the investigators will examine the association between epigenetic status and genotype at APOA2 and mRNA expression of the gene, and concentrations of metabolites in the blood. This study will increase the understanding of how genetics and diet act together to promote weight gain, and may eventually have implications for dietary recommendations that make use of genetic information.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
December 31, 2017
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
January 1, 2017
Actual (reported)December 1, 2017
Actual (reported)December 31, 2017
Actual (reported)January 29, 2018
Actual (reported)March 2, 2018
Actual (reported)Body mass index (BMI)
BMI calculated based on weight (kg) and height (meters) information from each participant using the equation BMI=kg/m2
One time point taken during the first visit of the participants to the studies used for the meta-analyses.
40 with CC and 40 with TT genotypes at APOA2 rs5082. Participants of each genotype will be further divided into two subgroups based on SFA intake: low, \<22 grams/day, high, ≥22 grams/day.
107 participants with CC genotype and 272 with TT genotype for APOA2 rs5082.
73 with CC and 170 with TT genotypes at APOA2 rs5082. Participants of each genotype will be further divided into two subgroups based on SFA intake: low, \<22 grams/day, high, ≥22 grams/day.
this is a metanalysis of previously obtained observational data. there is not intervention on any of the cohorts.
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Individuals extracted from the BPRHS, GOLDN and Framingham Studies
JM-USDA-HNRCA at Tufts University
Boston, Massachusetts, 02111, United States
Delgado-Lista J, Perez-Jimenez F, Tanaka T, Perez-Martinez P, Jimenez-Gomez Y, Marin C, Ruano J, Parnell L, Ordovas JM, Lopez-Miranda J. An apolipoprotein A-II polymorphism (-265T/C, rs5082) regulates postprandial response to a saturated fat overload in healthy men. J Nutr. 2007 Sep;137(9):2024-8. doi: 10.1093/jn/137.9.2024.
Corella D, Peloso G, Arnett DK, Demissie S, Cupples LA, Tucker K, Lai CQ, Parnell LD, Coltell O, Lee YC, Ordovas JM. APOA2, dietary fat, and body mass index: replication of a gene-diet interaction in 3 independent populations. Arch Intern Med. 2009 Nov 9;169(20):1897-906. doi: 10.1001/archinternmed.2009.343.
Jose M Ordovas, PHD
JM-USDA-HNRCA at Tufts University
602 participants (actual enrollment reported by the registry).
First Submitted
January 29, 2018
First Posted
March 2, 2018
Study Start
January 1, 2017
Actual (reported)Study of Variation Over Time in the Oral Microbiome
Contact the study team to confirm eligibility.
Smith CE, Ordovas JM, Sanchez-Moreno C, Lee YC, Garaulet M. Apolipoprotein A-II polymorphism: relationships to behavioural and hormonal mediators of obesity. Int J Obes (Lond). 2012 Jan;36(1):130-6. doi: 10.1038/ijo.2011.24. Epub 2011 Mar 8.
Corella D, Tai ES, Sorli JV, Chew SK, Coltell O, Sotos-Prieto M, Garcia-Rios A, Estruch R, Ordovas JM. Association between the APOA2 promoter polymorphism and body weight in Mediterranean and Asian populations: replication of a gene-saturated fat interaction. Int J Obes (Lond). 2011 May;35(5):666-75. doi: 10.1038/ijo.2010.187. Epub 2010 Oct 26.
Corella D, Arnett DK, Tsai MY, Kabagambe EK, Peacock JM, Hixson JE, Straka RJ, Province M, Lai CQ, Parnell LD, Borecki I, Ordovas JM. The -256T>C polymorphism in the apolipoprotein A-II gene promoter is associated with body mass index and food intake in the genetics of lipid lowering drugs and diet network study. Clin Chem. 2007 Jun;53(6):1144-52. doi: 10.1373/clinchem.2006.084863. Epub 2007 Apr 19.
Tucker KL, Mattei J, Noel SE, Collado BM, Mendez J, Nelson J, Griffith J, Ordovas JM, Falcon LM. The Boston Puerto Rican Health Study, a longitudinal cohort study on health disparities in Puerto Rican adults: challenges and opportunities. BMC Public Health. 2010 Mar 1;10:107. doi: 10.1186/1471-2458-10-107.
Lai CQ, Wojczynski MK, Parnell LD, Hidalgo BA, Irvin MR, Aslibekyan S, Province MA, Absher DM, Arnett DK, Ordovas JM. Epigenome-wide association study of triglyceride postprandial responses to a high-fat dietary challenge. J Lipid Res. 2016 Dec;57(12):2200-2207. doi: 10.1194/jlr.M069948. Epub 2016 Oct 24.
DAWBER TR, MEADORS GF, MOORE FE Jr. Epidemiological approaches to heart disease: the Framingham Study. Am J Public Health Nations Health. 1951 Mar;41(3):279-81. doi: 10.2105/ajph.41.3.279. No abstract available.
Lai CQ, Smith CE, Parnell LD, Lee YC, Corella D, Hopkins P, Hidalgo BA, Aslibekyan S, Province MA, Absher D, Arnett DK, Tucker KL, Ordovas JM. Epigenomics and metabolomics reveal the mechanism of the APOA2-saturated fat intake interaction affecting obesity. Am J Clin Nutr. 2018 Jul 1;108(1):188-200. doi: 10.1093/ajcn/nqy081.
Primary Completion
December 1, 2017
Actual (reported)Study Completion
December 31, 2017
Actual (reported)Last Updated
March 2, 2018
Record last verified: 2018-03
we are getting deidentified data from dbGAP and we cannot shared with any other group
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