Links Between Perception of Temporal Order Judgment and Causality in Schizophrenia

NCT03432000 | Terminated

• 1 other identifier: 2017-A03019-44
• Study Type: interventional
• Target: 52
• Locations: 1 country
• Sites: 1

Brief Summary

People with schizophrenia show disturbances in the perception of time. Among these alterations are the perturbations of the temporal order judgment. They are characterized by the fact that, as opposed to the general population, people with schizophrenia require a longer time interval between two successive stimuli to estimate which of the two events appeared first. If these alterations are now well documented, their consequences remain little explored. Among these consequences could however appear distortions of the judgment of causality (likely to underlie certain delusional interpretations) as well as a distressing experience of loss of the continuity of the lived experience (that could contribute to the alterations basic of self-awareness).

Conditions

Schizophrenia

Outcome Measures

Primary Outcomes (1)

• Comparison of the scores obtained by subjects with schizophrenia vs. the controls for the causal tasks, according to the delays between stimuli (stopping the moving launcher and appearance of the static object).

  Michotte paradigm: evaluate the links (correlation) between perception of temporal sequencing and perception of causality using an adapted experimental paradigm

  eight months

Secondary Outcomes (1)

• Comparisons of the scores obtained on the Time Experiment Rating Examination of Anomalous World Experience Scale (EAWE).

  eight months

Study Arms (2)

subjects with schizophrenia

EXPERIMENTAL

Performances on temporal task Subjective alterations of time perception in patients with an adapted scale (EAWE) Global symptomatology with PANSS (positive and negative symptom scale)

Other: Performances of patients and controls on temporal task

healthy subjects

SHAM COMPARATOR

Evaluate the links (correlation) between perception of temporal sequencing and perception of causality using an adapted experimental paradigm (Michotte paradigm) and to compare performance between healthy subjects and controls Investigate the existence of a correlation between these alterations and the peculiarities of the subjective experience of time (EAWE scale) in the group of subjects with schizophrenia

Other: Performances of patients and controls on temporal task

Interventions

Performances of patients and controls on temporal task OTHER

To carry out this work, we will rely on an experimental paradigm (derived from Michotte's paradigm) which makes it possible to explore the links between temporal sequencing and perception of causality, validated in the normal subject. subjective consequences of these alterations will be explored using a phenomenological-inspired clinical scale (EAWE time-scale items)

healthy subjects; subjects with schizophrenia

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Subjects with schizophrenia:
• Age from 18 to 45 years
• Diagnosis of schizophrenia according to DSM V criteria
• French mother tongue
• Stable symptomatology
• Normal or corrected visual acuity (\> 0.8 at Snellen scale) and normal color vision
• Patients who gave informed consent to participate in the study
• Control subjects (healthy volunteers):
• Age from 18 to 45 years
• Absence of neurological and psychiatric disorders
• French mother tongue

You may not qualify if:

• Recent addiction and abuse of cannabis or any other substance (according to DSM V criteria)
• Neurological disorders of vascular, infectious or neurodegenerative origin
• Taking somatic drugs with a cerebral or mental impact (eg corticosteroids)
• Disabling sensory disturbances, and in particular visual acuity
• Participation in a Neuro Cognitive Remediation Program
• Schizophrenia resistant to neuroleptic treatments
• Persons protected by law (pregnant women, minors, major under guardianship ...)

Sponsors & Collaborators

• Hôpital le Vinatier: lead

Study Sites (1)

Vial Veronique

Bron, Auvergne-Rhône-Alpes, 69678, France

Location

MeSH Terms

Conditions

Schizophrenia

Condition Hierarchy (Ancestors)

Schizophrenia Spectrum and Other Psychotic Disorders; Mental Disorders

Study Officials

• MARTIN BRICE

  CH LE VINATIER

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: This study consists in: * evaluate the links (correlation) between perception of temporal sequencing and perception of causality using an adapted experimental paradigm (Michotte paradigm) and to compare performance between healthy subjects and controls * investigate the existence of a correlation between these alterations and the peculiarities of the subjective experience of time (EAWE scale) in the group of subjects with schizophrenia The measures that will be realized are: * Performances of patients and controls on temporal task * Subjective alterations of time perception in patients with an adapted scale (EAWE) * Global symptomatology with PANSS (positive and negative symptom scale)

Study Record Dates

• First Submitted: February 7, 2018
• First Posted: February 13, 2018
• Study Start: February 1, 2018
• Primary Completion: May 24, 2022
• Study Completion: May 24, 2022
• Last Updated: August 1, 2025

Record last verified: 2025-07

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)