Basic Auditory Processing and Auditory Hallucinations

NCT02887794 | Completed

• 1 other identifier: 2016-A00141-50
• Study Type: interventional
• Target: 59
• Locations: 1 country
• Sites: 1

Brief Summary

Schizophrenia is a severe psychiatric disorder that affects approximately 1% of the population worldwide. Although pathophysiology of this disease remains unclear, a growing interest is emerging for low-level sensory function, acknowledging that deficits in early stages of sensory processing are related to higher-order cognitive disturbances in schizophrenia. In the field of auditory processing, symptoms as auditory-hallucinations were found correlated with disabilities to discriminate psychoacoustic parameters of sounds.

Conditions

Schizophrenia

Keywords

pitch discrimination; auditory processing disorders; auditory perception; auditory-verbal hallucinations; theory of mind

Outcome Measures

Primary Outcomes (1)

• percentage error in discrimination test psychoacoustic Tone Matching Task

  Our main hypothesis is that Auditory Hallucinations Rating Scale (AHRS) scores are correlated with the percentage of wrong answers in a Tone-Matching Task test.

  immediately after treatment

Secondary Outcomes (1)

• Score the item hallucinations of psychometric ( positive and negative syndrome ) scale

  immediately after treatment

Study Arms (1)

30 patients with schizophrenia

EXPERIMENTAL

Measure the correlation between the score on the scale psychometric AHRS (Auditory Hallucination Rating Scale) to measure HAV and performance scores discrimination test psychoacoustic Tone Matching Task in subjects suffering from schizophrenia and HAV.

Other: Clinical and psychoacoustic measures

Interventions

Clinical and psychoacoustic measures OTHER

Our study focuses on psychoacoustic tests, specialist care protocols (psychotherapy, neuromodulation ...) being made independently of our study, as part of medical activity of Cerletti care unit or differentiated protocols. Thus, our study shows no individual benefit for the patient. However, a better understanding of the neurophysiological mechanisms underlying auditory hallucinatory phenomenon could allow a better management of these patients in the near future

30 patients with schizophrenia

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age from 18 to 65 years old
• Meeting DSM-5.0 criteria for schizophrenia
• Auditory Hallucinations Rating Scale ≥ 8
• Negative βHCG level if woman
• Effective contraception if woman
• Consent to be included in the study

You may not qualify if:

• Hearing impairment
• Neurologic disorder
• Other psychiatric disorder from the DSM-5.0 section II
• Developed musical abilities (regular practice of singing or a musical instrument)
• Pregnancy
• Does not consent to be included in the study
• Lacking in legal capacity

Sponsors & Collaborators

• Hôpital le Vinatier: lead

Study Sites (1)

Ch Le Vinatier

Lyon, Auvergne-Rhône-Alpes, 69678, France

Location

MeSH Terms

Conditions

Schizophrenia; Auditory Perceptual Disorders; Hallucinations

Condition Hierarchy (Ancestors)

Schizophrenia Spectrum and Other Psychotic Disorders; Mental Disorders; Auditory Diseases, Central; Retrocochlear Diseases; Ear Diseases; Otorhinolaryngologic Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Perceptual Disorders; Neurobehavioral Manifestations; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Cognition Disorders; Neurocognitive Disorders

Study Officials

• Haesebaert Frédéric, PH

  CH LE VINATIER

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 3, 2016
• First Posted: September 2, 2016
• Study Start: October 6, 2016
• Primary Completion: June 30, 2021
• Study Completion: July 31, 2021
• Last Updated: August 15, 2022

Record last verified: 2022-08

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)