Emotion Regulation in Binge Eating and Purging Among Adolescents

NCT03429114 | Completed

• 1 other identifier: 40075
• Study Type: observational
• Target: 47
• Locations: 1 country
• Sites: 1

Brief Summary

The study will examine the neural and behavioral correlates of emotion regulation in adolescents engaging in binge eating and/or purging and healthy adolescents. Furthermore, it will look at the influence of executive function on emotion regulation in this population. This study will allow us to gain further understanding of the neural basis of emotion regulation in this age group. Moreover, this study supports the need to develop new treatment approaches based on a better understanding of the brain processes associated with eating disorders.

Conditions

Binge Eating; Purging (Eating Disorders)

Outcome Measures

Primary Outcomes (3)

• Brain activity during emotion conflict

  Functional magnetic resonance imaging will be used to measure brain activity during a task where participants respond to images of faces with emotional expressions overlaid with an emotion word written in text. We will focus on brain response during this task when emotion face vs word are in conflict.

  Baseline

• Brain activity during emotion regulation

  Functional magnetic resonance imaging will be used to measure brain activity during a task where participants attempt to regulate emotional responses.

  Baseline

• Brain activity during cognitive control and emotion response

  Functional magnetic resonance imaging will be used to measure brain activity during a task where participants engage in cognitive control and respond to emotional stimuli.

  Baseline

Secondary Outcomes (3)

• Behavioral performance on emotion conflict task

  Baseline

• Behavioral performance on emotion regulation task

  Baseline

• Behavioral performance on cognitive control and emotion regulation task

  Baseline

Study Arms (2)

Binge eating/purging

Adolescents engaging in recurrent binge eating and/or purging behavior.

Other: Magnetic resonance imaging

Healthy comparison

Adolescents who do not have a history of eating disorders

Other: Magnetic resonance imaging

Interventions

Magnetic resonance imaging OTHER

We will conduct MRI and fMRI brain scans to compare brain function between groups.

Binge eating/purging; Healthy comparison

Eligibility Criteria

• Age: 14 Years - 18 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Female adolescents between ages 14-18.

You may qualify if:

• Female
• Ages 14-18
• with or without current binge eating and/or purging behaviors

You may not qualify if:

• We exclude patients of clinically significant low weight (\<85% ideal body weight using CDC norms for height, age, and gender) and those with contraindications for MRI (e.g., orthodontia, metallic implants). Participants also will be without evidence of current or past major neurological (e.g., seizures, psychosis, head trauma) or major sensory deficit.

Sponsors & Collaborators

• Stanford University: lead

Study Sites (1)

Stanford University, Department of Psychiatry

Stanford, California, 94305, United States

Location

MeSH Terms

Conditions

Bulimia; Feeding and Eating Disorders

Interventions

Magnetic Resonance Spectroscopy

Condition Hierarchy (Ancestors)

Hyperphagia; Signs and Symptoms, Digestive; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Mental Disorders

Intervention Hierarchy (Ancestors)

Spectrum Analysis; Chemistry Techniques, Analytical; Investigative Techniques

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professo

Study Record Dates

• First Submitted: February 2, 2018
• First Posted: February 12, 2018
• Study Start: October 15, 2017
• Primary Completion: September 1, 2022
• Study Completion: September 1, 2022
• Last Updated: December 6, 2022

Record last verified: 2022-12

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)