Study to Evaluate Efficacy and Safety of PF-04965842 With or Without Topical Medications in Subjects Aged 12 Years and Older With Moderate to Severe Atopic Dermatitis
JADE EXTEND
A PHASE 3 MULTI-CENTER, LONG-TERM EXTENSION STUDY INVESTIGATING THE EFFICACY AND SAFETY OF ABROCITINIB, WITH OR WITHOUT TOPICAL MEDICATIONS, ADMINISTERED TO SUBJECTS AGED 12 YEARS AND OLDER WITH MODERATE TO SEVERE ATOPIC DERMATITIS
3 other identifiers
interventional
3,166
28 countries
539
Brief Summary
B7451015 is a Phase 3 study to evaluate Abrocitinib with or without Topical Medications in patients aged 12 years and older who have moderate to severe atopic dermatitis and have completed a qualifying parent study. The efficacy and safety of two dosage strengths of Abrocitinib, 100 mg and 200 mg taken orally once daily, will be evaluated over variable lengths of study participation. The study consists of a 92 week initial treatment period followed by a variable length secondary treatment period during which subjects will receive treatment with open-label abrocitinib until availability of commercial product in their country, or until the sponsor terminates the study in that country. The B7451015 study also includes a sub-study evaluating whether abrocitinib has any potential effects on adolescent bone with regard to abnormal bone findings in knee MRI. The sub-study will be conducted in selected countries at selected sites. Eligible subjects are those who were 12 to \<18 years of age at the screening visit of the qualifying parent study and who are currently participating in the main B7451015 study. The sub-study will include serial Magnetic Resonance Imaging (MRI) annually and continue until all enrolled subjects are 18 years of age and have been imaged at least once or have discontinued/withdrawn.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_3
Started Mar 2018
Longer than P75 for phase_3
539 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
December 20, 2017
CompletedFirst Posted
Study publicly available on registry
February 6, 2018
CompletedStudy Start
First participant enrolled
March 8, 2018
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 22, 2025
CompletedStudy Completion
Last participant's last visit for all outcomes
December 22, 2025
CompletedJanuary 15, 2026
January 1, 2026
7.8 years
December 20, 2017
January 14, 2026
Conditions
Keywords
Outcome Measures
Primary Outcomes (5)
Treatment emergent adverse events
The incidence of treatment emergent adverse events
Throughout study regardless of availability of commercial product until at least 2024, or until the sponsor terminates the study; an estimated maximum of 8 years
Serious adverse events and adverse events leading to discontinuation
The incidence of serious adverse events and adverse events leading to discontinuation
Throughout study regardless of availability of commercial product until at least 2024, or until the sponsor terminates the study; an estimated maximum of 8 years
Change from baseline in clinical laboratory values
Change from baseline in clinical laboratory values
Throughout study regardless of availability of commercial product until at least 2024, or until the sponsor terminates the study; an estimated maximum of 8 years
Change from baseline in electrocardiogram (ECG) measurements
Change from baseline in electrocardiogram (ECG) measurements
Throughout study regardless of availability of commercial product until at least 2024, or until the sponsor terminates the study; an estimated maximum of 8 years
Change from baseline in vital signs
Change from baseline in vital signs
Throughout study regardless of availability of commercial product until at least 2024, or until the sponsor terminates the study; an estimated maximum of 8 years
Secondary Outcomes (13)
Investigator's Global Assessment (IGA)
Baseline, Week 2, Week 4, Week 12, Week 24, Week 36, Week 48, Week 60, Week 72, Week 84, Week 92
Eczema Area and Severity Index (EASI)
Throughout study regardless of availability of commercial product until at least 2024, or until the sponsor terminates the study; an estimated maximum of 8 years
Pruritus Numerical Rating Scale (NRS)
Baseline, Week 2, Week 4, Week 12, Week 24, Week 36, Week 48, Week 60, Week 72, Week 84, Week 92
Patient Global Assessment (PtGA)
Baseline, Week 2, Week 4, Week 12, Week 24, Week 36, Week 48, Week 60, Week 72, Week 84, Week 92
Body Surface Area (BSA) affected
Throughout study regardless of availability of commercial product until at least 2024, or until the sponsor terminates the study; an estimated maximum of 8 years
- +8 more secondary outcomes
Study Arms (2)
Abrocitinib 100 mg
EXPERIMENTALAbrocitinib 100 mg QD PO
Abrocitinib 200 mg
EXPERIMENTALAbrocitinib 200 mg QD PO
Interventions
For subjects whose dose was changed from 100 mg Abrocitinib to placebo, one tablet will be administered to be taken orally once daily for the remainder of the study.
In the initial treatment period, Abrocitinib 100 mg, administered as two tablets to be taken orally once daily.
In the initial treatment period, Abrocitinib 200 mg, administered as two tablets to be taken orally once daily.
Eligibility Criteria
You may qualify if:
- Evidence of a personally signed and dated informed consent document indicating that the subject or their parent(s)/legal guardian, if applicable, have been informed of all pertinent aspects of the study.
- Willing and able to comply with scheduled visits, treatment plan, laboratory tests and other study procedures.
- Must have completed the full treatment period of a qualifying Parent study OR must have completed the full rescue treatment period of a qualifying Parent study (if applicable) OR must have completed the full open-label run-in period in B7451014 and did not meet the protocol-specified response criteria at Week 12.
- Female subjects who are of childbearing potential (which includes all female subjects aged 12 years and older, regardless of whether they have experienced menarche) must ot be intending to become pregnant, currently pregnant, or lactating. The following onditions apply:
- Female subjects of childbearing potential must have a confirmed negative pregnancy test prior to allocation to treatment.
- Female subjects of childbearing potential must agree to use a highly effective method of contraception (as per Section 4.4.1) for the duration of the active treatment period and for at least 28 days after the last dose of investigational product.
- For Czech Republic only, 5 b. is revised and 5 c. is added to require:
- Female subjects of childbearing potential 15 years of age who are at risk of pregnancy must agree to use a highly effective method of contraception for the duration of the active treatment period and for at least 28 days after the last dose of investigational product.
- c. Female subjects less than 15 years of age must not be sexually active, and abstinence per the below definition should be confirmed prior to enrollment. NOTE: Sexual abstinence, defined as completely and persistently refraining from all heterosexual intercourse (including during the entire period of risk associated with the study treatments) may obviate the need for contraception ONLY if this is the preferred and usual lifestyle of the subject.
- \. Female subjects of non-childbearing potential must meet at least 1 of the following criteria:
- Have undergone a documented hysterectomy and/or bilateral oophorectomy;
- Have medically confirmed ovarian failure; or
- Achieved postmenopausal status, defined as follows: cessation of regular menses for at least 12 consecutive months with no alternative pathological or physiological cause and have a serum follicle-stimulating hormone (FSH) level confirming the postmenopausal state. All other female subjects (including female subjects with tubal ligations) are considered to be of childbearing potential. 7. Must agree to avoid prolonged exposure to the sun and not to use tanning booths, sun lamps or other ultraviolet light sources during the study.
You may not qualify if:
- Other acute or chronic medical or psychiatric condition including recent (within the past year) or active suicidal ideation or behavior or laboratory abnormality that may increase the risk associated with study participation or investigational product administration or may interfere with the interpretation of study results and, in the judgment of the investigator, would make the subject inappropriate for entry into this study.
- Currently have active forms of other inflammatory skin diseases, ie, not AD or have evidence of skin conditions (eg, psoriasis, seborrheic dermatitis, Lupus) at the time of Day -1 that would interfere with evaluation of atopic dermatitis or response to treatment.
- Discontinued from treatment (or rescue treatment period/open-label run-in period, if applicable) early in a qualifying Parent study OR triggered a discontinuation criterion at any point during the qualifying Parent study which in the opinion of the investigator, or sponsor, is an ongoing safety concern.
- Ongoing adverse event in the qualifying Parent study which in the opinion of the investigator, or sponsor, is an ongoing safety concern.
- Investigator site staff members directly involved in the conduct of the study and their family members, site staff members otherwise supervised by the investigator, or subjects who are Pfizer employees, including their family members, directly involved in the conduct of the study.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Pfizerlead
Study Sites (539)
Total Skin and Beauty Dermatology Center, PC
Birmingham, Alabama, 35205, United States
Clinical Research Center of Alabama, LLC
Birmingham, Alabama, 35209, United States
University of Alabama at Birmingham - Dermatology Research Clinic
Birmingham, Alabama, 35233, United States
University of Alabama at Birmingham Hospital Outreach Lab
Birmingham, Alabama, 35233, United States
Clinical Research Center of Alabama, LLC
Birmingham, Alabama, 35244, United States
The University of Alabama at Birmingham, Department of Dermatology
Birmingham, Alabama, 35294, United States
Emmaus Research Center, Inc.
Anaheim, California, 92804, United States
California Dermatology & Clinical Research Institute
Encinitas, California, 92024, United States
First OC Dermatology Research Inc
Fountain Valley, California, 92708, United States
Marvel Research, LLC
Huntington Beach, California, 92647, United States
Tilda Research Inc.
Irvine, California, 92612, United States
Beach Allergy and Asthma Specialty Group, A Medical Corporation
Long Beach, California, 90808, United States
Keck School of Medicine of University of Southern California
Los Angeles, California, 90033, United States
Wallace Medical Group, Inc
Los Angeles, California, 90056, United States
Allergy & Asthma Associates of Southern California dba Southern California Research
Mission Viejo, California, 92691, United States
Dermatology Specialists, Inc.
Oceanside, California, 92056, United States
Peninsula Headlands LLC
Rolling Hills Estates, California, 90274, United States
UC Davis Health
Sacramento, California, 95816, United States
MedDerm Associates
San Diego, California, 92103, United States
University of California San Diego Dermatology
San Diego, California, 92122, United States
Synergy Dermatology
San Francisco, California, 94132, United States
San Luis Dermatology and Laser Clinic
San Luis Obispo, California, 93405, United States
Southern California Dermatology, Inc.
Santa Ana, California, 92701, United States
Wolverine Clinical Trials, Llc
Santa Ana, California, 92705, United States
Mosaic Dermatology
Santa Monica, California, 90403, United States
Clinical Science Institute
Santa Monica, California, 90404, United States
Asthma and Allergy Associates, PC
Colorado Springs, Colorado, 80907, United States
Colorado Springs Dermatology Clinic, PC
Colorado Springs, Colorado, 80910, United States
Skin Care Research
Boca Raton, Florida, 33486, United States
Renaissance Research and Medical Group, Inc
Cape Coral, Florida, 33991, United States
Florida Academic Centers Research and Education, LLC
Coral Gables, Florida, 33134, United States
Skin Research Institute
Coral Gables, Florida, 33146, United States
Moonshine Research Center, Inc.
Doral, Florida, 33166, United States
Homestead Research Institute
Homestead, Florida, 33030, United States
Clinical Neuroscience Solutions, Inc.
Jacksonville, Florida, 32256, United States
Solutions Through Advanced Research, Inc.
Jacksonville, Florida, 32256, United States
C & R Research Services USA, Inc
Kendall, Florida, 33183, United States
Clinical Trials Solutions
Miami, Florida, 33126, United States
Global Health Clinical Trials Corp
Miami, Florida, 33135, United States
Baumann Cosmetic and Research Institute
Miami, Florida, 33137, United States
Suncoast Research Associates
Miami, Florida, 33144, United States
La Salud Research Clinic, Inc.
Miami, Florida, 33155, United States
Nicklaus Children's Hospital
Miami, Florida, 33155, United States
South Miami Medical & Research Group, Inc.
Miami, Florida, 33155, United States
Ciocca Dermatology, PA
Miami, Florida, 33173, United States
Miami Dermatology & Laser Research, LLC
Miami, Florida, 33173, United States
INTERMED Medical Research Center, Inc
Miami, Florida, 33175, United States
Suncoast Research Associates
Miami, Florida, 33184, United States
Savin Medical Group LLC
Miami Lakes, Florida, 33014, United States
Wellness Clinical Research, LLC
Miami Lakes, Florida, 33016, United States
Park Avenue Dermatology
Orange Park, Florida, 32073, United States
Clinical Neuroscience Solutions, Inc.
Orlando, Florida, 32801, United States
AdventHealth Orlando
Orlando, Florida, 32803, United States
AdventHealth Pediatric Dermatology Orlando
Orlando, Florida, 32803, United States
Advent Health Orlando - Investigational Drug Services
Orlando, Florida, 32804, United States
Outpatient Services Center - AdventHealth Orlando
Orlando, Florida, 32804, United States
Pediatric Outpatient Procedures and Sedation
Orlando, Florida, 32804, United States
Accel Research Sites - Nona Pediatric Center
Orlando, Florida, 32829, United States
Olympian Clinical Research
St. Petersburg, Florida, 33709, United States
Clinical Research Trials of Florida, Inc.
Tampa, Florida, 33607, United States
Clinical Research Trials of Florida
Tampa, Florida, 33607, United States
ForCare Clinical Research
Tampa, Florida, 33613, United States
University of South Florida; Asthma, Allergy and Immunology Clinical Research Unit
Tampa, Florida, 33613, United States
Olympian Clinical Research
Tampa, Florida, 33615, United States
Integrated Clinical Research
West Palm Beach, Florida, 33406, United States
Columbus Regional Research Institute
Columbus, Georgia, 31904, United States
IACT Health
Columbus, Georgia, 31904, United States
One Health Research Clinic Atlanta, LLC
Johns Creek, Georgia, 30097, United States
Dermatologic Surgery Specialists, PC
Macon, Georgia, 31217, United States
Meridian Clinical Research
Savannah, Georgia, 31406, United States
ASR, LLC
Nampa, Idaho, 83687, United States
Midwest Allergy Sinus Asthma, SC
Normal, Illinois, 61761, United States
NorthShore University HealthSystem - Dermatology
Skokie, Illinois, 60077, United States
NorthShore University HealthSystem Dermatology Clinical Trials Unit
Skokie, Illinois, 60077, United States
Dundee Dermatology
West Dundee, Illinois, 60118, United States
Ds Research
Clarksville, Indiana, 47129, United States
Dawes Fretzin Clinical Research Group, LLC
Indianapolis, Indiana, 46250, United States
The Indiana Clinical Trials Center
Plainfield, Indiana, 46168, United States
The South Bend Clinic Center for Research
South Bend, Indiana, 46617, United States
Kansas City Dermatology, PA
Overland Park, Kansas, 66215, United States
Skin Sciences, PLLC
Louisville, Kentucky, 40217, United States
Qualmedica Research, LLC.
Owensboro, Kentucky, 42301, United States
Owensboro Dermatology Associates
Owensboro, Kentucky, 42303, United States
Meridian Clinical Research, LLC
Baton Rouge, Louisiana, 70808, United States
Avant Research Associates LLC
Crowley, Louisiana, 70526, United States
Tulane University Health Sciences Center
New Orleans, Louisiana, 70112, United States
Institute for Asthma and Allergy
Chevy Chase, Maryland, 20815, United States
DermAssociates, LLC
Rockville, Maryland, 20850, United States
Chesapeake Clinical Research, Inc.
White Marsh, Maryland, 21162, United States
Tufts Medical Center
Boston, Massachusetts, 02111, United States
Massachusetts General Hospital - Clinical Unit for Research Trials in Skin (CURTIS)
Boston, Massachusetts, 02114, United States
MetroBoston Clinical Partners, LLC
Brighton, Massachusetts, 02135, United States
Clarkston Skin Research
Clarkston, Michigan, 48346, United States
Henry Ford Medical Center, New Center One
Detroit, Michigan, 48202, United States
Onyx Clinical Research
Flint, Michigan, 48507, United States
Hamzavi Dermatology
Fort Gratiot, Michigan, 48059, United States
Revival Research Institute, LLC
Troy, Michigan, 48084, United States
Somerset Skin Centre
Troy, Michigan, 48084, United States
Henry Ford Medical Center - Farmington Road
West Bloomfield, Michigan, 48322, United States
Clinical Research Institute, Inc.
Minneapolis, Minnesota, 55402, United States
Mayo Clinic
Rochester, Minnesota, 55905, United States
MediSearch Clinical Trials
Saint Joseph, Missouri, 64506, United States
Saint Louis University Dermatology
St Louis, Missouri, 63104, United States
Skin Specialists PC
Omaha, Nebraska, 68144, United States
Forest Hills Dermatology Group
Kew Gardens, New York, 11415, United States
Icahn School of Medicine at Mount Sinai
New York, New York, 10029, United States
UR Dermatology Clinical Trials Unit at College Town
Rochester, New York, 14620, United States
Investigational Drug Service
Rochester, New York, 14642, United States
Cary Dermatology Center, PA
Cary, North Carolina, 27511, United States
Accellacare - Cary
Cary, North Carolina, 27518, United States
Medication Management, LLC
Greensboro, North Carolina, 27408, United States
M3-Wake Research, Inc.
Raleigh, North Carolina, 27612, United States
Carolina Research Center, Inc.
Shelby, North Carolina, 28150, United States
PMG Research of Wilmington LLC
Wilmington, North Carolina, 28411, United States
PMG Research of Wilmington, LLC
Wilmington, North Carolina, 28411, United States
PMG Research of Winston-Salem, LLC
Winston-Salem, North Carolina, 27103, United States
Winston-Salem Dermatology and Surgery Center, PLLC
Winston-Salem, North Carolina, 27103, United States
Bexley Dermatology Research
Bexley, Ohio, 43209, United States
The Ohio State University Wexner Medical Center
Columbus, Ohio, 43210, United States
The Ohio State University Dermatology East
Gahanna, Ohio, 43230, United States
Lynn Health Science Institute
Oklahoma City, Oklahoma, 73112, United States
Newton Clinical Research
Oklahoma City, Oklahoma, 73120, United States
Vital Prospects Clinical Research Institute, P.C.
Tulsa, Oklahoma, 74136, United States
Portland Clinical Research dba Columbia Asthma & Allergy Clinic
Clackamas, Oregon, 97015, United States
Velocity Clinical Research, Medford
Medford, Oregon, 97504, United States
Oregon Medical Research Center
Portland, Oregon, 97201, United States
Oregon Health & Science University
Portland, Oregon, 97239, United States
Paddington Testing Co, Inc.
Philadelphia, Pennsylvania, 19103, United States
Synexus Clinical Research US, Inc.
Anderson, South Carolina, 29621, United States
MUSC SCTR Research Nexus Clinic and Laboratory
Charleston, South Carolina, 29425, United States
Health Concepts
Rapid City, South Dakota, 57702, United States
Tanenbaum Dermatology Center
Memphis, Tennessee, 38117, United States
Clinical Neuroscience Solutions, Inc.
Memphis, Tennessee, 38119, United States
International Clinical Research - Tennessee LLC
Murfreesboro, Tennessee, 37130, United States
Arlington Research Center, Inc.
Arlington, Texas, 76011, United States
The University of Texas Health Science Center Houston
Bellaire, Texas, 77401, United States
Menter Dermatology Research Institute
Dallas, Texas, 75246, United States
Center for Clinical Studies, LTD. LLP
Houston, Texas, 77004, United States
Ventavia Research Group
Hurst, Texas, 76054, United States
Austin Institute for Clinical Research, Inc.
Pflugerville, Texas, 78660, United States
Texas Dermatology and Laser Specialists
San Antonio, Texas, 78218, United States
Dermatology Clinical Research Center of San Antonio
San Antonio, Texas, 78229, United States
Center for Clinical Studies, LTD.LLP
Webster, Texas, 77598, United States
Summit Clinical Research, LLC
Franklin, Virginia, 23851, United States
Virginia Clinical Research, Inc
Norfolk, Virginia, 23502, United States
Virginia Dermatology and Skin Cancer Center
Norfolk, Virginia, 23502, United States
Fort Norfolk Diagnostic Center
Norfolk, Virginia, 23510, United States
Pace Dermatology Associates
Lakewood, Washington, 98499, United States
Dermatology Associates of Seattle
Seattle, Washington, 98101, United States
Dermatology Specialists of Spokane
Spokane, Washington, 99202, United States
Principle Research Solutions
Spokane, Washington, 99204, United States
MultiCare Allenmore Hospital
Tacoma, Washington, 98405, United States
Multicare Institute for Research and Innovation
Tacoma, Washington, 98405, United States
Pace Dermatology Associates
Tacoma, Washington, 98405, United States
Children's Hospital of Wisconsin Investigational Drug Service
Milwaukee, Wisconsin, 53226, United States
Children's Hospital of Wisconsin Translational Research Unit
Milwaukee, Wisconsin, 53226, United States
CONEXA Investigación Clínica S.A.
CABA, Buenos Aires, C1012AAY, Argentina
Framingham Centro Medico
La Plata, Buenos Aires, B1902COS, Argentina
Hospital Universitario Austral
Pilar, Buenos Aires, B1629ODT, Argentina
Servicio de Investigacion de Patolog-ias Alergicas del Instituto ABC - Rosario
Rosario, Santa Fe Province, 2000, Argentina
Psoriahue Medicina Interdisciplinaria
C.a.b.a., C1425DKG, Argentina
CINME Centro de Investigaciones Metabolicas
C.a.b.a, C1027AAP, Argentina
Woden Dermatology
Phillip, Australian Capital Territory, 2606, Australia
St George Dermatology & Skin Cancer Centre
Kogarah, New South Wales, 2217, Australia
Australian Clinical Research Network
Maroubra, New South Wales, 2035, Australia
Royal North Shore Hospital
St Leonards, New South Wales, 2065, Australia
The Skin Hospital
Westmead, New South Wales, 2145, Australia
The Skin Centre
Benowa, Queensland, 4217, Australia
Veracity Clinical Research Pty Ltd
Woolloongabba, Queensland, 4102, Australia
North Eastern Health Specialists
Campbelltown, South Australia, 5074, Australia
Eastern Health - Box Hill Hospital
Box Hill, Victoria, 3128, Australia
Skin Health Institute Inc.
Carlton, Victoria, 3053, Australia
Sinclair Dermatology
East Melbourne, Victoria, 3002, Australia
Royal Melbourne Hospital
Parkville, Victoria, 3050, Australia
The Royal Children's Hospital
Parkville, Victoria, 3052, Australia
Emeritus Research
Camberwell, VIC 3124, Australia
Royal Melbourne Hospital
Parkville, 3052, Australia
Royal North Shore Hospital
Saint Leonards NSW, 2065, Australia
University Hospital Brussels
Brussels, 1090, Belgium
Cliniques Universitaires Saint-Luc
Brussels, B 1200, Belgium
University Hospital Antwerp
Edegem, 2650, Belgium
Instituto de Dermatologia e Estética do Brasil LTDA
Rio de Janeiro, Rio de Janeiro, 22470-220, Brazil
Hospital de Clinicas de Porto Alegre (HCPA)
Porto Alegre, Rio Grande do Sul, 90035-903/90035-003, Brazil
Associacao dos Funcionarios Públicos do Estado do Rio Grande do Sul - Hospital Ernesto Dornelles
Porto Alegre, Rio Grande do Sul, 90160-093, Brazil
Fundacao do ABC - Faculdade de Medicina do ABC
Santo André, São Paulo, 09060-870, Brazil
Tecnolab Medicina Diagnostica
Santo André, São Paulo, 09070-230, Brazil
Pesquisare Saude S/S Ltda
Santo André, São Paulo, 09080-110, Brazil
Tecnolab - Unidade Matriz
São Bernardo do Campo, São Paulo, 09750-670, Brazil
IBPClin Pesquisa Clinica
Rio de Janeiro, 20241-180, Brazil
MHAT Dobrich AD
Dobrich, 9300, Bulgaria
MC Asklepii" OOD
Dupnitsa, 2600, Bulgaria
MHAT ''Dr. Tota Venkova'' AD
Gabrovo, 5300, Bulgaria
"Acibadem City Clinic MHAT Tokuda" EAD
Sofia, 1407, Bulgaria
"DCC Aleksandrovska" EOOD
Sofia, 1431, Bulgaria
"DCC Fokus-5-Medical Establishment for OutpatientCare"EOOD
Sofia, 1463, Bulgaria
Military Medical Academy MHAT Sofia
Sofia, 1606, Bulgaria
Dermatology Clinic "Sofia" - group practice for specialized outpatient medical care
Sofia, 1756, Bulgaria
"Mc Synexus Sofia" Eood
Sofia, 1784, Bulgaria
ACIBADEM City Clinic Diagnostic-Consultative Center EOOD
Sofia, 1784, Bulgaria
Medical Center Synexus Sofia EOOD-branch Stara Zagora
Stara Zagora, 6000, Bulgaria
"ACIBADEM City Clinic Medical Center Varna" EOOD
Varna, 9000, Bulgaria
"DCC Mladost-M Varna" OOD
Varna, 9000, Bulgaria
Dermatology Research Institute
Calgary, Alberta, T1Y0B4, Canada
Dermatology Research Institute
Calgary, Alberta, T2J7E1, Canada
Beacon Dermatology
Calgary, Alberta, T3E 0B2, Canada
Stratica Medical
Edmonton, Alberta, T5K 1X3, Canada
Alberta Dermasurgery Centre
Edmonton, Alberta, T6G 1C3, Canada
CARE Clinic Ltd
Red Deer, Alberta, T4P-1K4, Canada
Dr. Chih-ho Hong Medical Inc
Surrey, British Columbia, V3R 6A7, Canada
University of British Columbia Department of Dermatology and Skin Science
Vancouver, British Columbia, V5Z 4E8, Canada
Pacific Dermaesthetics Inc.
Vancouver, British Columbia, V6H4E1, Canada
Winnipeg Clinic
Winnipeg, Manitoba, R3C 0N2, Canada
Wiseman Dermatology Research Inc.
Winnipeg, Manitoba, R3M 3Z4, Canada
Karma Clinical Trials, Inc.
St. John's, Newfoundland and Labrador, A1A 4Y3, Canada
CCA Medical Research
Ajax, Ontario, L1S 7K8, Canada
SimcoDerm Medical and Surgical Dermatology Center
Barrie, Ontario, L4M 7G1, Canada
Kingsway Clinical Research
Etobicoke, Ontario, M8X 1Y9, Canada
Medicor Research Inc
Greater Sudbury, Ontario, P3C 1X3, Canada
Sudbury Skin Clinique
Greater Sudbury, Ontario, P3C 1X8, Canada
Derm Effects
London, Ontario, N6H 5L5, Canada
Lynderm Research Inc.
Markham, Ontario, L3P 1X2, Canada
DermEdge Research
Mississauga, Ontario, L4Y 4C5, Canada
North Bay Dermatology Centre
North Bay, Ontario, P1B 3Z7, Canada
The Centre for Clinical Trials
Oakville, Ontario, L6J 7W5, Canada
Oshawa Clinic Dermatology Trials
Oshawa, Ontario, L1H 1B9, Canada
Dermatology Ottawa Research Centre
Ottawa, Ontario, K2C 3N2, Canada
SKiN Centre for Dermatology
Peterborough, Ontario, K9J 5K2, Canada
The Centre for Dermatology
Richmond Hill, Ontario, L4B 1A5, Canada
York Dermatology Clinic and Research Centre
Richmond Hill, Ontario, L4C 9M7, Canada
North York Research Inc.
Toronto, Ontario, M2N3A6, Canada
Toronto Research Centre
Toronto, Ontario, M3H5Y8, Canada
Research Toronto
Toronto, Ontario, M4W 2N4, Canada
AvantDerm
Toronto, Ontario, M5A 3R6, Canada
Manna Research Inc.(Toronto)
Toronto, Ontario, M9W 4L6, Canada
K.Papp Clinical Research Inc.
Waterloo, Ontario, N2J 1C4, Canada
XLR8 Medical Research Inc.
Windsor, Ontario, N8T 1E6, Canada
Clinique de Radiologie du Saguenay Enr.
Chicoutimi, Quebec, G7H 6B9, Canada
Intermed groupe santé
Chicoutimi, Quebec, G7H 7Y8, Canada
Innovaderm Research Inc.
Montreal, Quebec, H2X 2V1, Canada
Centre de Recherche Dermatologique du Quebec metropolitain (CRDQ)
Québec, Quebec, G1V 4X7, Canada
Diex Research Sherbrooke Inc.
Sherbrooke, Quebec, J1L 0H8, Canada
Dr. Rachel Asiniwasis, Medical Professional Corp.
Regina, Saskatchewan, S4V1R9, Canada
Centre de Recherche Saint-Louis inc.
Québec, G1W 4R4, Canada
Centro Medico SkinMed Limitada
Santiago, Santiago Metropolitan, 7580206, Chile
Clinica Dermacross S.A.
Santiago, Santiago Metropolitan, 7640881, Chile
CEC Spa
Santiago, Santiago Metropolitan, 7750495, Chile
MIRES (M Y F Estudios Clínicos Limitada)
Santiago, Santiago Metropolitan, 7750495, Chile
Hospital Clinico Universidad de Chile
Santiago, Santiago Metropolitan, 8380456, Chile
Centro Internacional de Estudios Clinicos - CIEC
Santiago, Santiago Metropolitan, 8420383, Chile
Peking University First Hospital
Beijing, Beijing Municipality, 100034, China
Beijing Friendship Hospital, Capital Medical University
Beijing, Beijing Municipality, 100050, China
The First Affiliated Hospital Of Fujian Medical University
Fuzhou, Fujian, 350005, China
The First Affiliated Hospital, Sun Yat-sen University
Guangzhou, Guangdong, 510080, China
The Third Affiliated Hospital, Sun Yat-sen University
Guangzhou, Guangdong, 510630, China
The University of Hong Kong - Shenzhen Hospital
Shenzhen, Guangdong, 518053, China
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Wuhan, Hubei, 430030, China
The second Xiangya Hospital,Central South University
Changsha, Hunan, 410011, China
The Third Xiangya Hospital of Central South University, Dermatological department
Changsha, Hunan, 410013, China
The First Affiliated Hospital With Nanjing University
Nanjing, Jiangsu, 210000, China
Dermatology Hospital of Jiangxi Province
Nanchang, Jiangxi, 330000, China
Jinan Central Hospital
Jinan, Shandong, 250013, China
Shandong Provincial Institute of Dermatology and Venereology & Shandong Provincial Hospital for Skin
Jinan, Shandong, 250022, China
Huashan Hospital Fudan University
Shanghai, Shanghai Municipality, 200040, China
Tianjin Medical University General Hospital, Dermatological Department
Tianjin, Tianjin Municipality, 300052, China
First Affiliated Hospital of Kunming Medical University
Kunming, Yunnan, 650032, China
The First Affiliated Hospital of Zhejiang University School of Medicine/Dermatology and STD Dept
Hangzhou, Zhejiang, 310003, China
Hangzhou Third Hospital
Hangzhou, Zhejiang, 310009, China
The Second Affiliated Hospital of Zhejiang University School of Medicine/Dermatology Dept
Hangzhou, Zhejiang, 310009, China
Zhejiang Provincial People's Hospital/Dermatology Department
Hangzhou, Zhejiang, 310014, China
Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University
Hangzhou, Zhejiang, 310016, China
The Second Affiliated Hospital of Army Medical University,PLA
Chongqing, 400037, China
Dermatology Department, Shanghai Changzheng Hospital
Shanghai, 200003, China
Xin Hua Hospital Affiliated to Shanghai Jiaotong University School of Medicine/Dermatology
Shanghai, 200092, China
Shanghai Dermatology Hospital
Shanghai, 200443, China
Lekarna Pod Kankem
Kunta Hora, 284 01, Czechia
Kozni ambulance Kutna Hora, s.r.o
Kutná Hora, 28401, Czechia
Dermamedica S.R.O.
Náchod, 547 01, Czechia
Lekarna U Stribrneho orla (Pharmacy)
Náchod, 547 01, Czechia
CCR Ostrava, s.r.o.
Ostrava, 702 00, Czechia
Lekarna Rezidence Nova Karolina
Ostrava, 702 00, Czechia
Apavar Lekarna
Ostrava, 70200, Czechia
Lekarna Fakultni Nemocnice Ostrava
Ostrava - Poruba, 708 52, Czechia
Fakultni Nemocnice Ostrava, Kozni oddeleni
Ostrava - Poruba, 70852, Czechia
BENU Lekarna
Pardubice, 530 02, Czechia
PRATIA Pardubice a.s.
Pardubice, 530 02, Czechia
Lekarna, Nemocnice Pardubickeho kraje, a.s. , Pardubicka nemocnice
Pardubice, 532 03, Czechia
Nemocnice Pardubickeho kraje, a.s., Pardubicka nemocnice
Pardubice, 53203, Czechia
Lekarna Pod Platany (Pharmacy)
Prague, 101 00, Czechia
Prof. MUDr.Petr Arenberger, DrSc. MBA
Prague, 11000, Czechia
Lekarna U Spasitele
Prague, 12800, Czechia
PRATIA Prague s.r.o.
Prague, 130 00, Czechia
Dermatovenerologicka ambulance
Svitavy, 56802, Czechia
Lekarna na Hranicni (Pharmacy)
Svitavy, 56802, Czechia
Krajska zdravotni a.s., Masarykova nemocnice o.z.
Ústí nad Labem, 401 13, Czechia
Lekarna Masarykovy nemocnice v Usti nad Labem, o.z.
Ústí nad Labem, 401 13, Czechia
Terveystalo Tampere
Tampere, 33100, Finland
Mehiläinen Neo
Turku, 20520, Finland
Turun yliopistollinen keskussairaala
Turku, 20520, Finland
Dermazentrum Augsburg
Augsburg, 86179, Germany
Licca Clinical Research Institute
Augsburg, 86179, Germany
Fachklinik Bad Bentheim
Bad Bentheim, 48455, Germany
Charite-Universitaetsmedizin Berlin
Berlin, 10117, Germany
Hautzentrum Friedrichshain Studien
Berlin, 10247, Germany
Rothhaar Studien GmbH
Berlin, 10783, Germany
ISA GmbH
Berlin, 10789, Germany
Klinikum Bielefeld Rosenhoehe
Bielefeld, 33647, Germany
Universitaetsklinikum Bonn
Bonn, 53105, Germany
Klinische Forschung Dresden GmbH
Dresden, 01069, Germany
Universitaetsklinikum Carl Gustav Carus der Technischen Universitaet Dresden
Dresden, 01307, Germany
Universitätsklinikum Erlangen
Erlangen, 91054, Germany
IKF Pneumologie GmbH & Co KG; Institut für klinische Forschung
Frankfurt, 60596, Germany
SRH Wald-Klinikum Gera GmbH
Gera, 07548, Germany
Klinische Forschung Hamburg GmbH
Hamburg, 20253, Germany
MENSINGDERMA research GmbH
Hamburg, 22391, Germany
Medizinische Hochschule Hannover
Hanover, 30625, Germany
Universitaetsklinikum Schleswig-Holstein, Campus Kiel
Kiel, 24105, Germany
Praxis Dr. med. Beate Schwarz
Langenau, 89129, Germany
Velocity Clinical Research Germany GmbH
Leipzig, 04103, Germany
Universitaetsklinikum Schleswig-Holstein, Campus Luebeck
Lübeck, 23538, Germany
Dermatologische Gemeinschaftspraxis
Mahlow, 15831, Germany
Dermatologische Gemeinschaftspraxis Dres. Quist
Mainz, 55128, Germany
Universitätsklinikum Marburg
Marburg, 35043, Germany
Ludwig-Maximilians-University Munich
Munich, 80337, Germany
University of Muenster
Münster, 48149, Germany
Klinische Forschung Schwerin GmbH
Schwerin, 19055, Germany
Hautaerztliche Gemeinschaftspraxis Dres. Leitz und Kollegen
Stuttgart, 70178, Germany
Clinexpert Kft.
Budapest, 1033, Hungary
SE AOK Bor, Nemikortani es Boronkologiai Klinika
Budapest, 1085, Hungary
Bp. Főváros XIX. Kerület Önkormányzat Kispesti Eü. Intézete
Budapest, 1195, Hungary
Debreceni Egyetem Klinikai Kozpont
Debrecen, 4032, Hungary
CRU Hungary Kft.
Encs, 3860, Hungary
Bugát Pál Kórház, Bőrgyógyászati Szakrendelés
Gyöngyös, 3200, Hungary
Trial Pharma Kft.
Győr, 9026, Hungary
Synexus Magyarország Egészségügyi Szolgáltató Kft. Synexus Gyula DRS
Gyula, 5700, Hungary
Trial Pharma Kft.
Kaposvár, 7400, Hungary
Borsod-Abaúj-Zemplén Megyei Központi Kórház és Gyermek Gasztroenterológia II. emelet
Miskolc, 3526, Hungary
Pecsi Tudomanyegyetem Klinikai Kozpont, Bor-,Nemikortani es Onkodermatologiai Klinika
Pécs, 7632, Hungary
Trial Pharma Kft.
Püspökladány, 4150, Hungary
Szegedi Tudomanyegyetem Szent-Györgyi Albert
Szeged, 6720, Hungary
ALLERGO-DERM BAKOS Kft.
Szolnok, 5000, Hungary
Medmare Bt
Veszprém, 8200, Hungary
Soroka University Medical Center
Beersheba, 8410101, Israel
Rabin Medical Center
Petah Tikva, 4941492, Israel
The Chaim Sheba Medical Center
Ramat Gan, 5265601, Israel
Tel-Aviv Sourasky Medical Center
Tel Aviv, 6423906, Israel
AOU Policlinico Sant'Orsola Malpighi
Bologna, BO, 40138, Italy
Universita degli Studi G. D'Annunzio -CeSi-MeT
Chieti, CH, 66100, Italy
Ospedale Policlinico San Martino
Genova, GE, 16132, Italy
AOU Policlinico di Modena Struttura complessa di Dermatologia
Modena, MO, 41124, Italy
Istituto Clinico Humanitas IRCSS - UOC di Dermatologia
Milan, 20089, Italy
ASST Fatebenefratelli Sacco
Milan, 20157, Italy
IFO lstituto Dermatologico San Gallicano IRCCS
Roma, 00144, Italy
Universita del Sacro Cuore, Policlinico Agostino Gemelli, Istituto Di Dermatologia
Rome, 00168, Italy
Kawashima Dermatology Clinic
Ichikawa, Chiba, 272-0033, Japan
Takagi Dermatological Clinic
Obihiro, Hokkaido, 080-0013, Japan
Dermatology Shimizu Clinic
Kobe, Hyōgo, 657-0846, Japan
Queen's square Medical Facilities Queen's square Dermatology and Allergology
Yokohama, Kanagawa, 220-6208, Japan
Noguchi Dermatology Clinic
Kamimashiki-gun, Kumamoto, 861-3106, Japan
Osaka Habikino Medical Center
Habikino, Osaka, 583-8588, Japan
Yoshioka Dermatology Clinic
Neyagawa, Osaka, 572-0838, Japan
Dermatology and Ophthalmology Kume Clinic
Sakai, Osaka, 593-8324, Japan
Iidabashi Skin Clinic
Chiyoda-ku, Tokyo, 102-0072, Japan
Fukuwa Clinic
Chuo-ku, Tokyo, 104-0031, Japan
Sumire Dermatology Clinic
Edogawa-ku, Tokyo, 133-0052, Japan
Matsuyama Dermatology Clinic
Nakano-ku, Tokyo, 165-0026, Japan
Tokyo Medical University Hospital
Shinjyuku-ku, Tokyo, 160-0023, Japan
Hoshikuma Dermatology・Allergy Clinic
Fukuoka, 814-0171, Japan
Matsuda Tomoko Dermatological Clinic
Fukuoka, 819-0167, Japan
Sanrui Hifuka
Saitama, 330-0854, Japan
Riga 1st Hospital, Clinic of Dermatology and STD
Riga, LV - 1001, Latvia
Aesthetic dermatology clinic of Prof. J. Kisis
Riga, LV-1003, Latvia
Health Centre 4 Ltd. Diagnostics Centre
Riga, LV-1003, Latvia
Childrens Clinical University Hospital State SLLC
Riga, LV-1004, Latvia
Health and Aesthetics Ltd
Riga, LV-1009, Latvia
Health Centre 4 Ltd, Dermatology Clinics
Riga, LV-1013, Latvia
Outpatient Clinic Of Ventspils
Ventspils, LV3601, Latvia
Clinical Research Institute S.C.
Saltillo, Coahuila, 25020, Mexico
Hospital Infantil de Mexico Federico Gomez
Del. Cuauhtemoc, Mexico City, 06720, Mexico
JM Research SC
Cuernavaca, Morelos, 62290, Mexico
Centro de Dermatologia de Monterrey
Monterrey, Nuevo León, 64460, Mexico
Unidad de Atención Médica e Investigación en Salud
Mérida, Yucatán, 97000, Mexico
Centro Multidisciplinario para el Desarrollo Especializado de la Investigacion Clinica en Yucatan
Mérida, Yucatán, 97130, Mexico
Derma Norte del Bajio S.C.
Aguascalientes, 20127, Mexico
Centro de Investigacion Integral MEDIVEST, S.C.
Chihuahua City, 31203, Mexico
Servicios Hospitalarios de Mexico S.A. de C.V. (Hospital Ángeles Chihuahua)
Chihuahua City, 31238, Mexico
Phylasis Clinicas Research S. de R.L. de C.V.
Cuautitlán Izcalli, 54769, Mexico
Hospital de Jesus, I.A.P.
Mexico City, 06090, Mexico
Cryptex Investigación Clínica, S.A. de C.V.
Mexico City, 06100, Mexico
Arke Estudios Clinicos Sa De Cv
Mexico City, 06700, Mexico
Trials in Medicine S.C.
Mexico City, 06700, Mexico
Eukarya Pharmasite S.C.
Monterrey, 64718, Mexico
SMIQ, S. de R. L. de C.V.
Querétaro, 76070, Mexico
Sociedad de Metabolismo y Corazon S.C.
Veracruz, 91900, Mexico
Universitair Medisch Centrum (UMC) Utrecht
Utrecht, 3584 CX, Netherlands
NZOZ Specjalistyczny Osrodek Dermatologiczny DERMAL s.c.
Bialystok, 15-453, Poland
KLIMED Marek Klimkiewicz
Bialystok, 15-704, Poland
Clinica Dermatoestetica Prywatny Gabinet Dermatologiczny i Alergologiczny
Bydgoszcz, 85-650, Poland
DERMAPOLIS Medical Dermatology Center dr n. med. Edyta Gębska
Chorzów, 41-500, Poland
Synexus Polska Sp. z o.o. Oddzial w Czestochowie
Częstochowa, 42-202, Poland
Uniwersyteckie Centrum Kliniczne Klinika Dermatologii, Wenerologii i Alergologii
Gdansk, 80-214, Poland
Neutrum Lekarze M. Hlebowicz i Partnerzy Spolka Partnerska
Gdansk, 80-462, Poland
Szpital Sw. Wojciecha
Gdansk, 80-462, Poland
Synexus Polska Sp. z o.o. Oddzial w Gdyni
Gdynia, 81-537, Poland
MCBK
Grodzisk Mazowiecki, 05-825, Poland
Synexus Polska Sp. z o.o. Oddzial w Katowicach
Katowice, 40-040, Poland
MULTIKLINIKA Salute Sp. z o.o.
Katowice, 40-123, Poland
Silmedic Sp. z o.o., Oddzial w Katowicach
Katowice, 40-282, Poland
Care Clinic Centrum Medyczne
Katowice, 40-568, Poland
Centrum Medyczne Angelius Provita
Katowice, 40-611, Poland
Pro Familia Altera Sp. z o.o.
Katowice, 40-648, Poland
Gabinet Dermatologiczny Beata Krecisz
Kielce, 25-217, Poland
Malopolskie Centrum Kliniczne
Krakow, 30-149, Poland
Centrum Badan Klinicznych JCI
Krakow, 30-348, Poland
Centrum Medyczne Plejady
Krakow, 30-363, Poland
Centrum Nowoczesnych Terapii "DOBRY LEKARZ" sp. z o.o.
Krakow, 31-011, Poland
AWP Klinika Dermatologii Pod Fortem Anna Wojas-Pelc
Krakow, 31-302, Poland
Centrum Medyczne Promed
Krakow, 31-411, Poland
Krakowskie Centrum Medyczne Sp. z o.o.
Krakow, 31-501, Poland
Prywatna Praktyka Lekarska - Adam Smialowski INTERMED KSAWEROW
Ksawerów, 95-054, Poland
NZOZ "DERMED" Centrum Medyczne Sp. z o.o. - Oddzial w Lodzi
Lodz, 90-265, Poland
Centrum Terapii Wspolczesnej J.M. Jasnorzewska Spolka Komandytowo-Akcyjna
Lodz, 90-338, Poland
Osrodek badan klinicznych AppleTree Clinics
Lodz, 90-349, Poland
Dermoklinika-Centrum Medyczne s.c. M. Kierstan, J. Narbutt, A. Lesiak
Lodz, 90-436, Poland
KO-MED Centra Kliniczne Lublin II
Lublin, 20-362, Poland
NZOZ "Med-Laser" Borzecki Spolka Jawna
Lublin, 20-406, Poland
Dermedic Jacek Zdybski
Ostrowiec Świętokrzyski, 27-400, Poland
Synexus Polska Sp. z o.o. Oddzial w Poznaniu
Poznan, 60-702, Poland
Clinical Research Center Sp. z o.o. MEDIC-R Sp. k.
Poznan, 60-848, Poland
Gabinety Lekarskie Rivermed
Poznan, 61-441, Poland
LIFT-MED Spolka Akcyjna
Rybnik, 44-200, Poland
Kliniczny Szpital Wojewodzki nr 1 im. F. Chopina, Klinika Dermatologii
Rzeszów, 35-055, Poland
EMED Centrum Uslug Medycznych Ewa Smialek
Rzeszów, 35-205, Poland
Andrzej Krolicki, Tomasz Kochanowski "Laser Clinic" S.C.
Szczecin, 70-332, Poland
Twoja Przychodnia Szczecinskie Centrum Medyczne
Szczecin, 71-500, Poland
Alergo-Med Specjalistyczna Przychodnia Lekarska Sp. z o.o.
Tarnów, 33-100, Poland
MICS Centrum Medyczne Warszawa
Warsaw, 00-874, Poland
Centrum Medyczne AMED
Warsaw, 01-518, Poland
MTZ Clinical Research Powered by Pratia
Warsaw, 02-172, Poland
Centralny Szpital Kliniczny Ministerstwa Spraw Wewnetrznych i Administracji w Warszawie
Warsaw, 02-507, Poland
RCMed Oddzial Warszawa
Warsaw, 02-657, Poland
Carpe Diem Centrum Medycyny Estetycznej
Warsaw, 02-661, Poland
REUMATIKA - "Centrum Reumatologii" NZOZ 2
Warsaw, 02-665, Poland
Synexus Polska Sp. z o.o. Oddzial w Warszawie
Warsaw, 02-672, Poland
ETG Warszawa
Warsaw, 02-793, Poland
Klinika Ambroziak Sp. z o.o.
Warsaw, 02-953, Poland
Wojskowy Instytut Medyczny, Klinika Dermatologiczna
Warsaw, 04-141, Poland
EMC Instytut Medyczny S.A. Przychodnia przy ul. Lowieckiej
Wroclaw, 50-220, Poland
Synexus Polska Sp. z o.o. Oddzial we Wroclawiu
Wroclaw, 50-381, Poland
Lukasz Matusiak "4Health"
Wroclaw, 50-566, Poland
Centrum Medyczne Oporow
Wroclaw, 52-416, Poland
Kliniczny Oddzial Chorob Wewnetrznych, Dermatologii i Alergologii
Zabrze, 41-800, Poland
SC Centrul Medical de Diagnostic si Tratament Ambulator Neomed SRL
Brasov, JUD. Brasov, 500283, Romania
Cabinet Medical de Dermatovenerologie Prof. Dr. Orasan Remus Ioan
Cluj-Napoca, JUD. CLUJ, 400105, Romania
SC Delta Health Care SRL
Bucharest, 014142, Romania
SBIH "Chelyabinsk Regional Clinical Dermatovenerology dispensary"
Chelyabinsk, 454048, Russia
Limited Liability Company "Medical Center "Rheuma-Med"
Kemerovo, 650070, Russia
Clinic of FSBEI HE Kirov SMU MOH Russia
Kirov, 610014, Russia
FSBI "State Research Centre of Dermatovenereology and Cosmetology" MoH RF
Moscow, 107076, Russia
NRC Institute of Immunology FMBA of Russia
Moscow, 115522, Russia
SBI RR "Skin and Venereal Dispensary"
Rostov-on-Don, 344007, Russia
SBI RR "Regional Clinical Skin and Veneral Dispensary"
Ryazan, 390046, Russia
LLC "Pierre Wolkenstein Clinic of Skin Diseases"
Saint Petersburg, 191123, Russia
Vitiligo center
Saint Petersburg, 191123, Russia
FSBEI HE "St. Petersburg State Pediatric Medical University" MoH RF
Saint Petersburg, 194100, Russia
Limited Liability Company "Sanavita"
Saint Petersburg, 194214, Russia
"Medical Research Institute", LLC
Saint Petersburg, 196084, Russia
FSBEI HE I.P.Pavlov SPbSMU MOH Russia
Saint Petersburg, 197022, Russia
RSBIH "Smolensk Regional Clinical Hospital"
Smolensk, 214018, Russia
Military Medical Academy
Belgrade, 11000, Serbia
Clinical Centre Nis
Niš, 18000, Serbia
General Hospital Pancevo
Pančevo, 26000, Serbia
Narodny ustav detskych chorob
Bratislava, 833 40, Slovakia
BeneDerma s.r.o.
Bratislava, 841 02, Slovakia
Derma therapy spol. s.r.o, Dermatovenerologicka ambulancia
Bratislava, 85101, Slovakia
Summit Clinical Research, s.r.o.
Bratislava - Mestská Cast Nove Mesto, 831 01, Slovakia
SKINKLINIK s.r.o.
Bratislava- Mestská Časť Nové Mesto, 83101, Slovakia
Nemocnica Kosice-Saca, a.s., 1. sukromna nemocnica, Kozna ambulancia
Kosice-Saca, 040 15, Slovakia
Derma-beauty, s.r.o., Dermatovenerologicka ambulancia
Nitra, 949 01, Slovakia
Fakultna nemocnica s poliklinikou Nove Zamky, Dermatovenerologicka klinika
Nové Zámky, 940 34, Slovakia
SANARE spol.s.r.o.
Svidník, 089 01, Slovakia
Korea University Ansan Hospital
Ansan-si, Gyeonggi-do, 15355, South Korea
Soon Chun Hyang University Bucheon Hospital
Bucheon-si, Gyeonggi-do, 14584, South Korea
Kyungpook National University Hospital
Daegu, 41944, South Korea
Chungnam National University Hospital CNUH
Daejeon, 35015, South Korea
Chonnam National University Hospital
Gwangju, 61469, South Korea
The Catholic University of Korea, Incheon St. Mary's Hospital
Incheon, 21431, South Korea
Inha University Hospital
Incheon, 22332, South Korea
Korea University Anam Hospital
Seoul, 02841, South Korea
Severance Hospital, Yonsei Univ. Health System
Seoul, 03722, South Korea
The Catholic University of Korea, Seoul St. Mary's Hospital
Seoul, 06591, South Korea
Chung-Ang University Hospital
Seoul, 06973, South Korea
Hallym University Kangnam Sacred Heart Hospital
Seoul, 07441, South Korea
Hospital Universitari Germans Trias i Pujol
Badalona, Barcelona, 08916, Spain
Hospital Sant Joan de Deu
Esplugues de Llobregat, Barcelona, 08950, Spain
Hospital Universitario de Gran Canaria Dr. Negrin
Las Palmas de Gran Canaria, LAS Palmas, 35010, Spain
Hospital Universitario Fundacion Alcorcon
Alcorcón, Madrid, 28922, Spain
Hospital Universitario Puerta de Hierro de Majadahonda
Majadahonda, Madrid, 28222, Spain
Hospital General Universitario de Alicante
Alicante, 03010, Spain
Hospital Clinic de Barcelona
Barcelona, 08036, Spain
Hospital de la Santa Creu i Sant Pau Servicio de Dermatologia
Barcelona, 08041, Spain
Hospital Universitario Reina Sofia
Córdoba, 14004, Spain
Hospital Universitario de La Princesa
Madrid, 28006, Spain
Hospital General Universitario Gregorio Maranon
Madrid, 28007, Spain
Hospital del Nino Jesus
Madrid, 28009, Spain
Hospital Universitario 12 de octubre
Madrid, 28041, Spain
Hospital Universitario La Paz
Madrid, 28046, Spain
Centro de Especialidades Mollabao (Area Sanitaria de Pontevedra e O Salnes)
Pontevedra, 36001, Spain
Hospital de Montecelo
Pontevedra, 36071, Spain
Hospital Universitario Virgen de la Macarena
Seville, 41009, Spain
Consorcio Hospital General Universitario de Valencia
Valencia, 46014, Spain
Hospital Universitario y Politecnico La Fe
Valencia, 46026, Spain
Hospital Universitario Miguel Servet
Zaragoza, 50009, Spain
Taipei Veterans General Hospital
Taipei, Taiwan (r.o.c), 11217, Taiwan
Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung City, 807, Taiwan
Taipei Medical University-Shuang Ho Hospital
New Taipei City, 23561, Taiwan
Chung Shan Medical University Hospital
Taichung, 402, Taiwan
Taichung Veterans General Hospital
Taichung, 40705, Taiwan
National Cheng-Kung University Hospital
Tainan, 704, Taiwan
National Taiwan University Hospital
Taipei, 100, Taiwan
Mackay Memorial Hospital
Taipei, 10449, Taiwan
Chang Gung Memorial Hospital Linkou Branch
Taoyuan, 333, Taiwan
Medinova Research
Wokingham, Berkshire, RG40 1XS, United Kingdom
MeDiNova West London Quality Research Sites
Wokingham, Berkshire, RG40 1XS, United Kingdom
Plymouth Hospitals NHS Trust, Derriford Hospital
Plymouth, Devon, PL6 8DH, United Kingdom
Royal free London NHS Foundation Trust
London, Greater London, NW3 2QG, United Kingdom
MeDiNova South London Quality Research Site
Orpington, KENT, BR5 3QG, United Kingdom
Accellacare North London
Northwood, Middlesex, HA6 2RN, United Kingdom
Barnsley Hospital NHS Foundation Trust
Barnsley, South Yorkshire, S75 2EP, United Kingdom
Sheffield Children's NHS Foundation Trust
Sheffield, South Yorkshire, S10 2TH, United Kingdom
Sheffield Teaching Hospitals NHS Foundation Trust, Northern General Hospital
Sheffield, South Yorkshire, S5 7AU, United Kingdom
MAC Clinical Research
Blackpool, FY2 0JH, United Kingdom
University Hospital Bristol NHS Foundation Trust
Bristol, BS2 8HW, United Kingdom
MAC Clinical Research
Cannock, WS11 0BN, United Kingdom
Accellacare Warwickshire
Coventry, CV3 4FJ, United Kingdom
West Glasgow Ambulatory Care Hospital
Glasgow, G3 8SJ, United Kingdom
Guy's Hospital-Guy's and St Thomas NHS Foundation Trust
London, SE1 9RT, United Kingdom
MAC Clinical Research Ltd
Manchester, M13 9NQ, United Kingdom
Accellacare South London
Orpington, BR5 3QG, United Kingdom
Accellacare Yorkshire
Shipley, BD18 3SA, United Kingdom
Related Publications (4)
Paller AS, Eichenfield LF, Irvine AD, Flohr C, Wollenberg A, Barbarot S, Bangert C, Spergel JM, Selfridge A, Biswas P, Fan H, Alderfer J, Watkins M, Koppensteiner H. Integrated Efficacy and Safety Analysis of Abrocitinib in Adolescents With Moderate-to-Severe Atopic Dermatitis. Allergy. 2025 Aug;80(8):2213-2224. doi: 10.1111/all.16512. Epub 2025 Mar 3.
PMID: 40028832DERIVEDSilverberg JI, Simpson EL, Pink AE, Weidinger S, Chan G, Biswas P, Clibborn C, Guler E. Switching from Dupilumab to Abrocitinib in Patients With Moderate-to-Severe Atopic Dermatitis: A Post Hoc Analysis of Efficacy After Treatment With Dupilumab in JADE DARE. Dermatol Ther (Heidelb). 2025 Feb;15(2):367-380. doi: 10.1007/s13555-024-01320-y. Epub 2025 Feb 4.
PMID: 39903335DERIVEDSilverberg JI, Thyssen JP, Lazariciu I, Myers DE, Guler E, Chovatiya R. Abrocitinib may improve itch and quality of life in patients with itch-dominant atopic dermatitis. Skin Health Dis. 2024 May 5;4(4):e382. doi: 10.1002/ski2.382. eCollection 2024 Aug.
PMID: 39104653DERIVEDSimpson EL, Silverberg JI, Nosbaum A, Winthrop KL, Guttman-Yassky E, Hoffmeister KM, Egeberg A, Valdez H, Zhang M, Farooqui SA, Romero W, Thorpe AJ, Rojo R, Johnson S. Integrated Safety Analysis of Abrocitinib for the Treatment of Moderate-to-Severe Atopic Dermatitis From the Phase II and Phase III Clinical Trial Program. Am J Clin Dermatol. 2021 Sep;22(5):693-707. doi: 10.1007/s40257-021-00618-3. Epub 2021 Aug 18.
PMID: 34406619DERIVED
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MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Study Officials
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Pfizer CT.gov Call Center
Pfizer
Study Design
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- interventional
- Phase
- phase 3
- Allocation
- RANDOMIZED
- Masking
- QUADRUPLE
- Who Masked
- PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
- Expanded Access
- Yes
Study Record Dates
First Submitted
December 20, 2017
First Posted
February 6, 2018
Study Start
March 8, 2018
Primary Completion
December 22, 2025
Study Completion
December 22, 2025
Last Updated
January 15, 2026
Record last verified: 2026-01
Data Sharing
- IPD Sharing
- Will share
Pfizer will provide access to individual de-identified participant data and related study documents (e.g. protocol, Statistical Analysis Plan (SAP), Clinical Study Report (CSR)) upon request from qualified researchers, and subject to certain criteria, conditions, and exceptions. Further details on Pfizer's data sharing criteria and process for requesting access can be found at: https://www.pfizer.com/science/clinical\_trials/trial\_data\_and\_results/data\_requests.