The Relationship Between Right-to-left Shunt and Brain White Matter Lesions in Patients With Migraine
CAMBRAIN
1 other identifier
observational
1,500
1 country
1
Brief Summary
The purpose of the study is to evaluate the prevalence of white matter lesions in Chinese migraineurs with and without right-to-left shunt. The aim is to study the relationship among right-to-left shunt, migraine and white matter lesions.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jun 2018
Typical duration for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
January 16, 2018
CompletedFirst Posted
Study publicly available on registry
February 1, 2018
CompletedStudy Start
First participant enrolled
June 15, 2018
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2020
CompletedStudy Completion
Last participant's last visit for all outcomes
December 30, 2020
CompletedJuly 23, 2020
March 1, 2020
2.5 years
January 16, 2018
July 21, 2020
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
contrast-enhanced transcranial Doppler (c-TCD)
Brain MRI
1 year
Study Arms (2)
Normal
Normal healthy individual without migraine.
Magraine
Clinical history of migraine diagnosed by a neurologist according to the International Classification of Headache Disorders.
Eligibility Criteria
We detect RLS through contrast-enhanced transcranial Doppler (c-TCD). The normal individuals will be selected to group 1, while those who suffer from migraine will be selected to group 2. All the participants are required to take c-TCD and brain MRI.
You may qualify if:
- patients who fulfilled the criteria for migraine according to the International Classification of Headache Disorders III-beta were included.
- healthy volunteers without a history of migraine were included as controls.
You may not qualify if:
- Subjects were excluded from the study if they had severe arterial stenosis, an insufficient temporal window, inadequate cubital venous access, and/or were unable to perform the Valsalva manoeuvre (VM) because of severe heart or lung disease.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
First hospital of Jilin Uni
Changchun, Jilin, 130000, China
Related Publications (1)
Del Sette M, Dinia L, Bonzano L, Roccatagliata L, Finocchi C, Parodi RC, Sivori G, Gandolfo C. White matter lesions in migraine and right-to-left shunt: a conventional and diffusion MRI study. Cephalalgia. 2008 Apr;28(4):376-82. doi: 10.1111/j.1468-2982.2008.01544.x. Epub 2008 Feb 22.
PMID: 18294247RESULT
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY CHAIR
Yingqi Xing, MD,PhD
The First Hospital of Jilin University
- PRINCIPAL INVESTIGATOR
Sibo Wang, MD,PhD
The First Hospital of Jilin University
- STUDY DIRECTOR
Yi Yang, MD,PhD
The First Hospital of Jilin University
- PRINCIPAL INVESTIGATOR
Yongsheng Gao, MD
The First Hospital of Jilin University
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Target Duration
- 1 Year
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
January 16, 2018
First Posted
February 1, 2018
Study Start
June 15, 2018
Primary Completion
December 1, 2020
Study Completion
December 30, 2020
Last Updated
July 23, 2020
Record last verified: 2020-03