Registry of Right-to-left Shunt Detection by Contrast-enhanced Transcranial Doppler in Chinese Population

NCT02425696 | Completed

• 1 other identifier: RLS-1dzx
• Study Type: observational
• Target: 1,100
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of the study is to evaluate the prevalence and extent of right-to-left shunt (RLS) in Chinese migraineurs, and the morbidity of silent cerebral infarction in migraineurs.

Conditions

Right-to-left Shunt; Migraine; Cerebral Infarction

Keywords

right-to-left shunt; contrast-enhanced transcranial Doppler; migraine; silent cerebral infarction

Outcome Measures

Primary Outcomes (1)

• contrast-enhanced transcranial Doppler

  1 year

Secondary Outcomes (1)

• brain MRI

  1 year

Study Arms (2)

group 1

Normal individuals without migraine

group 2

Migraineurs

Eligibility Criteria

• Age: 16 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

We detect RLS through contrast-enhanced transcranial Doppler (c-TCD). The normal individuals will be selected to group 1, while those who suffer from migraine will be selected to group 2. Patients of group 2 with large RLS are required to take TTE and brain MRI.

You may qualify if:

• For group 1: Normal healthy individual without migraine.
• For group 2: Clinical history of migraine diagnosed by a neurologist according to the International Classification of Headache Disorders.

You may not qualify if:

• Subjects with stenotic intracranial or extracranial arteries or intracranial abnormalities diagnosed with TCD.

Sponsors & Collaborators

• Yingqi Xing: lead

Study Sites (1)

First Hospital of Jilin University

Changchun, Jilin, 130000, China

Location

Related Publications (1)

• Jiang XH, Wang SB, Tian Q, Zhong C, Zhang GL, Li YJ, Lin P, You Y, Guo R, Cui YH, Xing YQ. Right-to-left shunt and subclinical ischemic brain lesions in Chinese migraineurs: a multicentre MRI study. BMC Neurol. 2018 Feb 14;18(1):18. doi: 10.1186/s12883-018-1022-7.

  PMID: 29444659 DERIVED

MeSH Terms

Conditions

Migraine Disorders; Cerebral Infarction

Condition Hierarchy (Ancestors)

Headache Disorders, Primary; Headache Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Brain Infarction; Brain Ischemia; Cerebrovascular Disorders; Stroke; Vascular Diseases; Cardiovascular Diseases; Infarction; Ischemia; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Necrosis

Study Officials

• Yingqi Xing, MD, PhD

  The First Hospital of Jilin University

  STUDY CHAIR

• Yi Yang, MD, PhD

  The First Hospital of Jilin University

  STUDY DIRECTOR

• Yuzhu Guo

  The First Hospital of Jilin University

  PRINCIPAL INVESTIGATOR

• Jie Zhang, MD

  The First Hospital of Jilin University

  PRINCIPAL INVESTIGATOR

• Sibo Wang

  The First Hospital of Jilin University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Year
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Director of Head and Neck Vascular Ultrasound Center

Study Record Dates

• First Submitted: April 21, 2015
• First Posted: April 24, 2015
• Study Start: June 1, 2015
• Primary Completion: August 1, 2016
• Study Completion: August 1, 2017
• Last Updated: January 19, 2018

Record last verified: 2016-10

Locations

CN (1)