The FVC/DLCO Ratio is a Useful Predictor of Pulmonary Hypertension in Patients With Interstitial Lung Disease

NCT03396120 | Completed

• 1 other identifier: AssiutU6
• Study Type: observational
• Target: 95
• Locations: 1 country
• Sites: 2

Brief Summary

Pulmonary hypertension (PH) is a common disorder among patients with interstitial lung disease (ILD). The symptoms are usually nonspecific and overlooked. Thus, a noninvasive screening modality is recommended for early detection of PH because of its potentially significant impact on treatment strategy and clinical outcomes. Objectives: To evaluate the usefulness of assessing forced vital capacity (FVC%), diffusion capacity of the lung for carbon monoxide (DLCO%), and FVC%/DLCO% ratio to predict pulmonary hypertension among patients with ILDs.

Conditions

Interstitial Lung Disease; Pulmonary Hypertension

Outcome Measures

Primary Outcomes (1)

• value of FVC/DLCO in predicting PAH in IPF

  To evaluate the usefulness of assessing forced vital capacity (FVC%), diffusion capacity of the lung for carbon monoxide (DLCO%), and FVC%/DLCO% ratio to predict pulmonary hypertension among patients with ILDs

  6 months

Interventions

Pulmonary function test DIAGNOSTIC_TEST

forced vital capacity and diffusing capacity

Also known as: FVC/DLCO

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

\- ILD was diagnosed on the basis of clinical, radiological and functional assessments

You may qualify if:

• This retrospective study included all patients diagnosed with interstitial lung disease (ILD) who were followed up by the chest department of a tertiary hospital between September 2016 and January 2017

You may not qualify if:

• patients with occupational history
• collagen vascular disease predisposing them to lung disorders
• patients who could not undergo pulmonary function testing

Sponsors & Collaborators

• Assiut University: lead

Study Sites (2)

AssiutU

Asyut, 71111, Egypt

Location

Pulmonology Departments

Asyut, 71111, Egypt

Location

MeSH Terms

Conditions

Lung Diseases, Interstitial; Hypertension, Pulmonary

Interventions

Respiratory Function Tests

Condition Hierarchy (Ancestors)

Lung Diseases; Respiratory Tract Diseases; Hypertension; Vascular Diseases; Cardiovascular Diseases

Intervention Hierarchy (Ancestors)

Diagnostic Techniques, Respiratory System; Diagnostic Techniques and Procedures; Diagnosis

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor of Pulmonology

Study Record Dates

• First Submitted: January 5, 2018
• First Posted: January 10, 2018
• Study Start: February 2, 2017
• Primary Completion: December 1, 2017
• Study Completion: December 31, 2017
• Last Updated: January 10, 2018

Record last verified: 2018-01

Data Sharing

• IPD Sharing: Will not share

Locations

EG (2)