Depot Medroxyprogesterone Acetate as Emergency Contraception

NCT03395756 | Completed Early Phase 1 FDA Drug

• 1 other identifier: HS-17-01006
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

Background: The prevalence of repeat unprotected intercourse after EC use in the same cycle demonstrate the need for more self-bridging emergency contraceptive options. We propose the use of intramuscular Depot Medroxyprogesterone acetate (DMPA) as EC, which has been shown to inhibit follicular activity within 24 hours, and provide on-going contraception via suppression or disruption of ovulation. Objective: The objective of this study is to explore the potential of depot medroxyprogesterone acetate (DMPA) given as a 150-mg intramuscular injection for use as an emergency contraceptive. Study population: Healthy regularly menstruating women aged 18-39 years old will be invited to participate if they fulfill inclusion criteria. The participants will undergo a screening visit during the midluteal phase of their cycle, and will be enrolled if a serum progesterone level is \>3ng/ml. Methodology: Participants will be assigned to one of three groups based on leading follicle size. Starting cycle Day 8, transvaginal ultrasounds will be performed to assess the size of the leading follicle. Once the follicle has reached the pre-assigned size, 150 mg IM DMPA will be administered. Blood will be collected for baseline hormonal assays. For 5 consecutive days, daily blood will be drawn for hormonal assays and daily transvaginal ultrasound will be performed to assess for signs of ovulation. The participant will then return for twice weekly progesterone levels for 2 weeks for study completion.

Conditions

Emergency Contraception; Contraception

Keywords

Depot Medroxyprogesterone acetate; Injectable birth control

Outcome Measures

Primary Outcomes (3)

• Ovulation

  Follicle rupture on ultrasound preceded by LH surge 21 IU/L or greater, followed by progesterone level 3 ng/ml or greater.

  5 days to 3 weeks

• Ovulation Suppression

  Lack of follicular rupture on ultrasound with or without appropriate LH surge of 21 IU/L or greater and without elevation in progesterone levels to 3 ng/ml or greater

  5 days to 3 weeks

• Ovulatory dysfunction

  Rupture of leading follicle without appropriate LH surge (less than 21 IU/L) and without appropriate progesterone elevation after rupture (less then 3 ng/ml)

  5 days to 3 weeks

Study Arms (3)

12-14 mm follicle size group

ACTIVE COMPARATOR

Once the participant's leading follicle reaches 12-14mm, she will receive an IM administration of 150 mg Depot-Medroxyprogesterone Acetate. Prior to administration, she will have blood drawn for baseline progesterone, estradiol, and LH levels. One hour after receiving the injection, she will have blood drawn for medroxyprogesterone acetate levels. The next day, she will undergo a transvaginal ultrasound to assess the leading follicle and will have blood drawn for progesterone, estradiol, LH, and medroxyprogesterone acetate levels. For the next 4 consecutive days, she will have daily transvaginal ultrasounds to assess for signs of follicular rupture, and blood draws for hormonal assays. After, she will return twice weekly for two weeks for blood draw for progesterone levels.

Drug: Depot-Medroxyprogestereone Acetate

15-17 mm follicle size group

ACTIVE COMPARATOR

Once the participant's leading follicle reaches 15-17mm, she will receive an IM administration of 150 mg Depot-Medroxyprogesterone Acetate. Prior to administration, she will have blood drawn for baseline progesterone, estradiol, and LH levels. One hour after receiving the injection, she will have blood drawn for medroxyprogesterone acetate levels. The next day, she will undergo a transvaginal ultrasound to assess the leading follicle and will have blood drawn for progesterone, estradiol, LH, and medroxyprogesterone acetate levels. For the next 4 consecutive days, she will have daily transvaginal ultrasounds to assess for signs of follicular rupture, and blood draws for hormonal assays. After, she will return twice weekly for two weeks for blood draw for progesterone levels.

Drug: Depot-Medroxyprogestereone Acetate

18 mm or greater follicle size group

ACTIVE COMPARATOR

Once the participant's leading follicle reaches 18mm or greater, she will receive an IM administration of 150 mg Depot-Medroxyprogesterone Acetate. Prior to administration, she will have blood drawn for baseline progesterone, estradiol, and LH levels. One hour after receiving the injection, she will have blood drawn for medroxyprogesterone acetate levels. The next day, she will undergo a transvaginal ultrasound to assess the leading follicle and will have blood drawn for progesterone, estradiol, LH, and medroxyprogesterone acetate levels. For the next 4 consecutive days, she will have daily transvaginal ultrasounds to assess for signs of follicular rupture, and blood draws for hormonal assays. After, she will return twice weekly for two weeks for blood draw for progesterone levels.

Drug: Depot-Medroxyprogestereone Acetate

Interventions

Depot-Medroxyprogestereone Acetate DRUG

Administration of 150 mg intramuscular depot medroxyprogesterone acetate

12-14 mm follicle size group; 15-17 mm follicle size group; 18 mm or greater follicle size group

Eligibility Criteria

• Age: 18 Years - 39 Years
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy women of reproductive age (18-39 years old) with BMI 18-30 kg/m2
• Regular menses for the last 3 months
• Cycle duration 24 to 35 days
• Women using copper IUD, sterilization, or barrier methods as current or preferred birth control method, and women reporting exclusive sex with women
• English- or Spanish-speaking

You may not qualify if:

• Any contraindications to progesterone contraception per teh CDC Medical Eligibility Criteria (Category 3 or 4)
• On medications that can alter, or be altered by, progesterone contraceptive steroid hormone (e.g., aminoglutethimide or other anti-steroid medication)
• Use of any hormonal contraceptive pill, patch, or vaginal ring in the month prior to recruitment
• Use of depot-medroxyprogesterone acetate in teh 10 months prior to recruitment
• Currently pregnant and/or breastfeeding
• History of allergic reaction to depot medroxyprogesterone acetate (rash, urticaria, anaphylaxis)

Sponsors & Collaborators

• University of Southern California: lead
• Society of Family Planning: collaborator

Study Sites (1)

University of Southern California Keck Medical Center

Los Angeles, California, 90033, United States

Location

Related Publications (30)

• Daniels K, Jones J, Abma J. Use of emergency contraception among women aged 15-44: United States, 2006-2010. NCHS Data Brief. 2013 Feb;(112):1-8.

  PMID: 23742711 BACKGROUND

• ESHRE CapriWorkshop Group. Emergency contraception. Widely available and effective but disappointing as a public health intervention: a review. Hum Reprod. 2015 Apr;30(4):751-60. doi: 10.1093/humrep/dev019. Epub 2015 Feb 11.

  PMID: 25678571 BACKGROUND

• Glasier A, Cameron ST, Blithe D, Scherrer B, Mathe H, Levy D, Gainer E, Ulmann A. Can we identify women at risk of pregnancy despite using emergency contraception? Data from randomized trials of ulipristal acetate and levonorgestrel. Contraception. 2011 Oct;84(4):363-7. doi: 10.1016/j.contraception.2011.02.009. Epub 2011 Apr 2.

  PMID: 21920190 BACKGROUND

• Turok DK, Gurtcheff SE, Handley E, Simonsen SE, Sok C, North R, Frost C, Murphy PA. A survey of women obtaining emergency contraception: are they interested in using the copper IUD? Contraception. 2011 May;83(5):441-6. doi: 10.1016/j.contraception.2010.08.011. Epub 2010 Sep 29.

  PMID: 21477687 BACKGROUND

• Mishell DR Jr. Pharmacokinetics of depot medroxyprogesterone acetate contraception. J Reprod Med. 1996 May;41(5 Suppl):381-90.

  PMID: 8725700 BACKGROUND

• Ortiz A, Hirol M, Stanczyk FZ, Goebelsmann U, Mishell DR. Serum medroxyprogesterone acetate (MPA) concentrations and ovarian function following intramuscular injection of depo-MPA. J Clin Endocrinol Metab. 1977 Jan;44(1):32-8. doi: 10.1210/jcem-44-1-32.

  PMID: 833262 BACKGROUND

• Fotherby K, Koetsawang S, Mathrubutham M. Pharmacokinetic study of different doses of Depo Provera. Contraception. 1980 Nov;22(5):527-36. doi: 10.1016/0010-7824(80)90105-5.

  PMID: 6451351 BACKGROUND

• Petta CA, Faundes A, Dunson TR, Ramos M, DeLucio M, Faundes D, Bahamondes L. Timing of onset of contraceptive effectiveness in Depo-Provera users. II. Effects on ovarian function. Fertil Steril. 1998 Nov;70(5):817-20. doi: 10.1016/s0015-0282(98)00309-4.

  PMID: 9806559 BACKGROUND

• Croxatto HB, Brache V, Pavez M, Cochon L, Forcelledo ML, Alvarez F, Massai R, Faundes A, Salvatierra AM. Pituitary-ovarian function following the standard levonorgestrel emergency contraceptive dose or a single 0.75-mg dose given on the days preceding ovulation. Contraception. 2004 Dec;70(6):442-50. doi: 10.1016/j.contraception.2004.05.007.

  PMID: 15541405 BACKGROUND

• Shen J, Che Y, Showell E, Chen K, Cheng L. Interventions for emergency contraception. Cochrane Database Syst Rev. 2017 Aug 2;8(8):CD001324. doi: 10.1002/14651858.CD001324.pub5.

  PMID: 28766313 BACKGROUND

• Wilcox AJ, Weinberg CR, Baird DD. Timing of sexual intercourse in relation to ovulation. Effects on the probability of conception, survival of the pregnancy, and sex of the baby. N Engl J Med. 1995 Dec 7;333(23):1517-21. doi: 10.1056/NEJM199512073332301.

  PMID: 7477165 BACKGROUND

• Long-term reversible contraception. Twelve years of experience with the TCu380A and TCu220C. Contraception. 1997 Dec;56(6):341-52.

  PMID: 9494767 BACKGROUND

• Harper CC, Speidel JJ, Drey EA, Trussell J, Blum M, Darney PD. Copper intrauterine device for emergency contraception: clinical practice among contraceptive providers. Obstet Gynecol. 2012 Feb;119(2 Pt 1):220-6. doi: 10.1097/AOG.0b013e3182429e0d.

  PMID: 22270272 BACKGROUND

• Wu S, Godfrey EM, Wojdyla D, Dong J, Cong J, Wang C, von Hertzen H. Copper T380A intrauterine device for emergency contraception: a prospective, multicentre, cohort clinical trial. BJOG. 2010 Sep;117(10):1205-10. doi: 10.1111/j.1471-0528.2010.02652.x. Epub 2010 Jul 7.

  PMID: 20618314 BACKGROUND

• Rowe P, Farley T, Peregoudov A, Piaggio G, Boccard S, Landoulsi S, Meirik O; IUD Research Group of the UNDP/UNFPA/WHO/World Bank Special Programme of Research; Development and Research Training in Human Reproduction. Safety and efficacy in parous women of a 52-mg levonorgestrel-medicated intrauterine device: a 7-year randomized comparative study with the TCu380A. Contraception. 2016 Jun;93(6):498-506. doi: 10.1016/j.contraception.2016.02.024. Epub 2016 Feb 23.

  PMID: 26916172 BACKGROUND

• Royer PA, Turok DK, Sanders JN, Saltzman HM. Choice of Emergency Contraceptive and Decision Making Regarding Subsequent Unintended Pregnancy. J Womens Health (Larchmt). 2016 Oct;25(10):1038-1043. doi: 10.1089/jwh.2015.5625. Epub 2016 Mar 31.

  PMID: 27032057 BACKGROUND

• Novikova N, Weisberg E, Stanczyk FZ, Croxatto HB, Fraser IS. Effectiveness of levonorgestrel emergency contraception given before or after ovulation--a pilot study. Contraception. 2007 Feb;75(2):112-8. doi: 10.1016/j.contraception.2006.08.015. Epub 2006 Oct 27.

  PMID: 17241840 BACKGROUND

• Jones J, Mosher W, Daniels K. Current contraceptive use in the United States, 2006-2010, and changes in patterns of use since 1995. Natl Health Stat Report. 2012 Oct 18;(60):1-25.

  PMID: 24988814 BACKGROUND

• Trussell J. Contraceptive failure in the United States. Contraception. 2011 May;83(5):397-404. doi: 10.1016/j.contraception.2011.01.021. Epub 2011 Mar 12.

  PMID: 21477680 BACKGROUND

• Sundaram A, Vaughan B, Kost K, Bankole A, Finer L, Singh S, Trussell J. Contraceptive Failure in the United States: Estimates from the 2006-2010 National Survey of Family Growth. Perspect Sex Reprod Health. 2017 Mar;49(1):7-16. doi: 10.1363/psrh.12017. Epub 2017 Feb 28.

  PMID: 28245088 BACKGROUND

• Curtis KM, Tepper NK, Jatlaoui TC, Berry-Bibee E, Horton LG, Zapata LB, Simmons KB, Pagano HP, Jamieson DJ, Whiteman MK. U.S. Medical Eligibility Criteria for Contraceptive Use, 2016. MMWR Recomm Rep. 2016 Jul 29;65(3):1-103. doi: 10.15585/mmwr.rr6503a1.

  PMID: 27467196 BACKGROUND

• Gemzell-Danielsson K, Berger C, P G L L. Emergency contraception -- mechanisms of action. Contraception. 2013 Mar;87(3):300-8. doi: 10.1016/j.contraception.2012.08.021. Epub 2012 Oct 29.

  PMID: 23114735 BACKGROUND

• Siriwongse T, Snidvongs W, Tantayaporn P, Leepipatpaiboon S. Effect of depo-medroxyprogesterone acetate on serum progesterone levels when administered on various cycle days. Contraception. 1982 Nov;26(5):487-93. doi: 10.1016/0010-7824(82)90147-0.

  PMID: 6218964 BACKGROUND

• Curtis KM, Jatlaoui TC, Tepper NK, Zapata LB, Horton LG, Jamieson DJ, Whiteman MK. U.S. Selected Practice Recommendations for Contraceptive Use, 2016. MMWR Recomm Rep. 2016 Jul 29;65(4):1-66. doi: 10.15585/mmwr.rr6504a1.

  PMID: 27467319 BACKGROUND

• Croxatto HB, Fuentealba B, Brache V, Salvatierra AM, Alvarez F, Massai R, Cochon L, Faundes A. Effects of the Yuzpe regimen, given during the follicular phase, on ovarian function. Contraception. 2002 Feb;65(2):121-8. doi: 10.1016/s0010-7824(01)00299-2.

  PMID: 11927114 BACKGROUND

• Croxatto HB, Brache V, Massai R, Alvarez F, Forcelledo ML, Pavez M, Cochon L, Salvatierra AM, Faundes A. Feasibility study of Nestorone-ethinylestradiol vaginal contraceptive ring for emergency contraception. Contraception. 2006 Jan;73(1):46-52. doi: 10.1016/j.contraception.2005.06.071. Epub 2005 Nov 14.

  PMID: 16371294 BACKGROUND

• Duijkers IJ, Louwe LA, Braat DD, Klipping C. One, two or three: how many directions are useful in transvaginal ultrasound measurement of ovarian follicles? Eur J Obstet Gynecol Reprod Biol. 2004 Nov 10;117(1):60-3. doi: 10.1016/j.ejogrb.2004.01.005.

  PMID: 15474246 BACKGROUND

• Pardthaisong T, Gray RH. In utero exposure to steroid contraceptives and outcome of pregnancy. Am J Epidemiol. 1991 Oct 15;134(8):795-803. doi: 10.1093/oxfordjournals.aje.a116152.

  PMID: 1835282 BACKGROUND

• Pardthaisong T, Gray RH, McDaniel EB, Chandacham A. Steroid contraceptive use and pregnancy outcome. Teratology. 1988 Jul;38(1):51-8. doi: 10.1002/tera.1420380108.

  PMID: 2845595 BACKGROUND

• Pardthaisong T, Yenchit C, Gray R. The long-term growth and development of children exposed to Depo-Provera during pregnancy or lactation. Contraception. 1992 Apr;45(4):313-24. doi: 10.1016/0010-7824(92)90053-v.

  PMID: 1387602 BACKGROUND

MeSH Terms

Interventions

Medroxyprogesterone Acetate

Intervention Hierarchy (Ancestors)

Medroxyprogesterone; Hydroxyprogesterones; Progesterone; Pregnenediones; Pregnenes; Pregnanes; Steroids; Fused-Ring Compounds; Polycyclic Compounds

Study Officials

• Robyn L Schickler, MD

  University of Southern California

  PRINCIPAL INVESTIGATOR

• Brian Nguyen, MD, MSCP

  University of Southern California

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: early phase 1
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Model Details: Participants in this study will be assigned to one of three groups based on leading follicle size: 12-14 mm, 15-17mm, and 18 mm or greater. Each group will receive the same medication (intramuscular depot medroxyprogesterone acetate), and be followed in the same manner for five consecutive days after administration with transvaginal ultrasound and blood draws for hormonal assays (progesterone, estradiol, and luteinizing hormone levels)

Study Record Dates

• First Submitted: January 4, 2018
• First Posted: January 10, 2018
• Study Start: August 31, 2018
• Primary Completion: October 30, 2020
• Study Completion: October 30, 2020
• Last Updated: November 5, 2020

Record last verified: 2020-11

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)