Effect of Intraoperative Lidocaine Infusion on Intraoperative Isoflurane Requirements
Effect of Intraoperative IV Lidocaine Infusion on Intraoperative Isoflurane Requirements
1 other identifier
interventional
50
0 countries
N/A
Brief Summary
Fifty patients were included in the study, divided into two equal groups (25 in each), underwent spinal fusion surgery.Control group: received normal saline. Lidocaine group: received lidocaine 2.0 mg/kg slowly IV before induction of anesthesia, followed by lidocaine IV infusion at a rate of 2.5 mg/kg/hr until the end of surgery. We evaluated the end-tidal isoflurane concentration required to maintain AAI index in the range of 20-25 during adult spinal fusion surgery.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable
Started Oct 2016
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
October 2, 2016
CompletedPrimary Completion
Last participant's last visit for primary outcome
October 2, 2017
CompletedStudy Completion
Last participant's last visit for all outcomes
December 15, 2017
CompletedFirst Submitted
Initial submission to the registry
December 17, 2017
CompletedFirst Posted
Study publicly available on registry
December 29, 2017
CompletedDecember 29, 2017
December 1, 2017
1 year
December 17, 2017
December 21, 2017
Conditions
Outcome Measures
Primary Outcomes (1)
effect of intraoperative IV lidocaine infusion on intraoperative end tidal isoflurane concentration
using gas analyzer for determination of end tidal isoflurane concentration (%) (ET-Iso) needed to maintain AAI index in the range 20-25.
every 15 minutes from induction of anesthesia until 90 minutes intraoperative.
Study Arms (2)
control group
ACTIVE COMPARATOR* Sodium chloride solution 10 mL IV just before induction of anesthesia * IV infusion during the surgery
lidocaine group
ACTIVE COMPARATOR* lidocaine 2 mg ̸ kg slowly IV just before induction of anesthesia * IV infusion during the surgery
Interventions
intraoperative IV infusion
Eligibility Criteria
You may qualify if:
- Adult patients underwent spinal fusion surgery ASA I, II and III
You may not qualify if:
- History of epilepsy hearing disorders known allergy to lidocaine BMI \> 35 significant cardiac diseases significant renal diseases liver dysfunction substance abuse chronic opioid use
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Related Publications (2)
Vesal N, Spadavecchia C, Steiner A, Kirscher F, Levionnois OL. Evaluation of the isoflurane-sparing effects of lidocaine infusion during umbilical surgery in calves. Vet Anaesth Analg. 2011 Sep;38(5):451-60. doi: 10.1111/j.1467-2995.2011.00636.x.
PMID: 21831050BACKGROUNDSaadawy IM, Kaki AM, Abd El Latif AA, Abd-Elmaksoud AM, Tolba OM. Lidocaine vs. magnesium: effect on analgesia after a laparoscopic cholecystectomy. Acta Anaesthesiol Scand. 2010 May;54(5):549-56. doi: 10.1111/j.1399-6576.2009.02165.x. Epub 2009 Nov 16.
PMID: 19919581BACKGROUND
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, CARE PROVIDER
- Purpose
- PREVENTION
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Assistant Professor
Study Record Dates
First Submitted
December 17, 2017
First Posted
December 29, 2017
Study Start
October 2, 2016
Primary Completion
October 2, 2017
Study Completion
December 15, 2017
Last Updated
December 29, 2017
Record last verified: 2017-12