Environment and Cardiovascular Disease: The Corinthia Study
Environmental Pollution and Health of Corinth Region. Corinthia Study
1 other identifier
observational
2,500
1 country
2
Brief Summary
Environmental factors constitute an important but underappreciated risk factor towards the development and progression of cardiovascular disease (CVD). Environmental exposure in variable pollutants is implicated in the derangement or propagation of adverse pathophysiological processes linked with atherosclerosis, including genetic, hemodynamic, metabolic, oxidative and inflammation parameters. However no data exists concerning environmental pollution in rural or semi-rural areas. Therefore the purpose of the "Corinthia" study is to examine the impact of environmental pollution in indices of cardiovascular morbidity and mortality in a cross-sectional and longitudinal design. Corinthia study began in October 2015 and is planned to recruit 2400 individuals from different regions of Corinthia country with different environmental exposure to pollutants and different patterns of soil-ground and/or air pollution until September 2018. Baseline measurements will include lifestyle measurements, anthropometric characteristics and a comprehensive cardiovascular examination. The follow-up is planned to extent, prospectively, up to 10 years and this study is anticipated to provide valuable data on the distinct impact of soil and air pollution in early markers of atherosclerosis and cardiovascular disease and in the overall impact of environment pollution to cardiovascular morbidity and mortality.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Oct 2015
Longer than P75 for all trials
2 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
October 20, 2015
CompletedFirst Submitted
Initial submission to the registry
November 20, 2017
CompletedFirst Posted
Study publicly available on registry
December 28, 2017
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 30, 2018
CompletedStudy Completion
Last participant's last visit for all outcomes
December 31, 2030
ExpectedDecember 28, 2017
December 1, 2017
2.9 years
November 20, 2017
December 26, 2017
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Major adverse cardiovascular events
Cardiovascular death, non fatal acute myocardial infarction, non fatal stroke
15 Years
Eligibility Criteria
We plan to recruit individuals living in three different areas according to environmental pollution i. Subjects living in areas with no evidence of soil/ground or air pollution ii. Subjects living in areas with air pollution iii. Subjects living in areas with soil/ground pollution
You may qualify if:
- Inhabitants of Corinthia Region
You may not qualify if:
- Inability and unwillingness to obtain informed consent
- Individuals less than 40 years of age
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (2)
1st Cardiology Department, Hippokration General Hospital
Athens, Attica, 11528, Greece
Hippokration Hospital, First Cardiology Clinic
Athens, 11528, Greece
Related Publications (1)
Oikonomou E, Lazaros G, Georgiopoulos G, Christoforatou E, Papamikroulis GA, Vogiatzi G, Chasikidis C, Zacharia E, Giannaki A, Bourouki E, Mavratzas T, Stofa E, Papakonstantinou M, Tousouli M, Tousoulis D. Environment and cardiovascular disease: rationale of the Corinthia study. Hellenic J Cardiol. 2016 May-Jun;57(3):194-197. doi: 10.1016/j.hjc.2016.06.001. Epub 2016 Jun 23.
PMID: 27451913BACKGROUND
Biospecimen
Blood
MeSH Terms
Conditions
Study Officials
- STUDY CHAIR
Dimitris Tousoulis
National and Kapodistrian University of Athens, Greece, First Cardiology Clinic, Hippokratio Hospital
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- ECOLOGIC OR COMMUNITY
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor of Cardiology
Study Record Dates
First Submitted
November 20, 2017
First Posted
December 28, 2017
Study Start
October 20, 2015
Primary Completion
September 30, 2018
Study Completion (Estimated)
December 31, 2030
Last Updated
December 28, 2017
Record last verified: 2017-12