The Effects of Aerobic Exercise in Microvascular Endothelium Function in Patients With Cardiovascular Diseases

NCT02514564 | Completed DMC

• 1 other identifier: Faperj-E-26/101.575
• Study Type: observational
• Target: 115
• Locations: 1 country
• Sites: 1

Brief Summary

This study evaluates the effects of different volumes of aerobic exercise training in cardiovascular parameters of patients with cardiovascular diseases enrolled in a cardiac rehabilitation program.

Conditions

Cardiovascular Diseases

Outcome Measures

Primary Outcomes (1)

• Changes in Skin microvascular blood flow

  Measured through a Laser Speckle Contrast Imaging equipment

  Change from baseline in skin microvascular blood flow at 6 months

Secondary Outcomes (2)

• Change in peak oxygen consumption

  Change from baseline in peak oxygen consumption at 6 months

• Change in weight

  Change from baseline in weight at 6 months

Study Arms (3)

2x/wk

This group will be consisted of patients that will perform exercise two times a week.

Behavioral: Exercise

3x/wk

This group will be consisted of patients that will perform exercise three times a week.

Behavioral: Exercise

Control

This group will not perform exercise.

Behavioral: Sedentarism

Interventions

Sedentarism BEHAVIORAL

Participants will remain sedentary.

Control

Exercise BEHAVIORAL

Patients included in the study will be enrolled in a cardiac rehabilitation program, in an independent manner of the study protocols.

2x/wk; 3x/wk

Eligibility Criteria

• Age: 40 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients treated in the hospital in which the exercise will be performed.

You may qualify if:

• sedentarism for at least 6 months;
• clinical diagnosis for coronary artery disease (occurrence of any acute coronary syndrome, including ST elevation or non-ST elevation myocardial infarction or unstable angina or by the diagnosis of obstructive coronary artery disease on coronary angiography in patients with stable angina).

You may not qualify if:

• nephropathies;
• decompensated cardiovascular diseases;
• liver diseases.

Sponsors & Collaborators

• Instituto Nacional de Cardiologia de Laranjeiras: lead

Study Sites (1)

Instituto Nacional de Cardiologia

Rio de Janeiro, Rio de Janeiro, 21040-900, Brazil

Location

Related Publications (3)

• Souza EG, De Lorenzo A, Huguenin G, Oliveira GM, Tibirica E. Impairment of systemic microvascular endothelial and smooth muscle function in individuals with early-onset coronary artery disease: studies with laser speckle contrast imaging. Coron Artery Dis. 2014 Jan;25(1):23-8. doi: 10.1097/MCA.0000000000000055.

  PMID: 24172594 BACKGROUND

• Cordovil I, Huguenin G, Rosa G, Bello A, Kohler O, de Moraes R, Tibirica E. Evaluation of systemic microvascular endothelial function using laser speckle contrast imaging. Microvasc Res. 2012 May;83(3):376-9. doi: 10.1016/j.mvr.2012.01.004. Epub 2012 Jan 31.

  PMID: 22326551 BACKGROUND

• Borges JP, Mediano MF, Farinatti P, Coelho MP, Nascimento PM, Lopes GO, Kopiler DA, Tibirica E. The Effects of Unsupervised Home-based Exercise Upon Functional Capacity After 6 Months of Discharge From Cardiac Rehabilitation: A Retrospective Observational Study. J Phys Act Health. 2016 Nov;13(11):1230-1235. doi: 10.1123/jpah.2016-0058. Epub 2016 Aug 24.

  PMID: 27333938 DERIVED

Biospecimen

Retention: SAMPLES WITHOUT DNA

Blood samples for nitrite/nitrate quantification.

MeSH Terms

Conditions

Cardiovascular Diseases

Interventions

Exercise

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Eduardo V Tibiriçá, PhD

  Instituto Fernandes Figueira

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: PhD

Study Record Dates

• First Submitted: July 30, 2015
• First Posted: August 3, 2015
• Study Start: December 1, 2014
• Primary Completion: December 1, 2016
• Study Completion: December 1, 2016
• Last Updated: March 27, 2026

Record last verified: 2026-03

Locations

BR (1)