Impact of Non Digestible Carbohydrate on Production of Phenolic Acids From Strawberry Juice

NCT03383809 | Completed DMC

• 1 other identifier: BB/MO27724/1-1
• Study Type: interventional
• Target: 15
• Locations: 1 country
• Sites: 1

Brief Summary

This is an acute human bioavailability study in self-reported healthy participants aged 20-70 years old. We hypothesize that combination of dietary polyphenolics and non-digestible carbohydrates (NDC) will increase the production of phenolic acids by bacteria in the human colon and these will be detected in urine. Participants will attend for three arms in a randomised order: Strawberry juice (a high polyphenol food), Inulin (NDC) or Mixture of strawberry juice and inulin.

Conditions

Healthy

Keywords

Self-reported healthy adults

Outcome Measures

Primary Outcomes (1)

• Phenolic acids bioavailability

  Urine excretion of phenolic acids

  0-24 hrs

Secondary Outcomes (4)

• Urolithin bioavailability

  0-24 hrs

• Glycaemic and appetite hormones measurements by ELISA

  0-8 hrs

• Mouth to caecum transit time

  0-8 hrs

• Gastric emptying time

  0-6 hrs

Study Arms (3)

Strawberry juice with inulin

EXPERIMENTAL

One dose of 300 g of strawberry with 10 g of inulin will be given to subjects in the form of juice

Dietary Supplement: Strawberry juice with Inulin

Strawberry juice

EXPERIMENTAL

One dose of 300 g of strawberry juice will be given to subjects in the form of juice

Dietary Supplement: Strawberry Juice

Inulin

EXPERIMENTAL

One dose of 10 g of inulin will be given to subjects in the form of a drink

Dietary Supplement: Inulin

Interventions

Strawberry juice with Inulin DIETARY_SUPPLEMENT

Mixture of polyphenols and non digestible carbohydrates

Strawberry juice with inulin

Strawberry Juice DIETARY_SUPPLEMENT

Source of Polyphenols

Strawberry juice

Inulin DIETARY_SUPPLEMENT

Source of non digestible carbohydrate

Inulin

Eligibility Criteria

• Age: 20 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Self-reported healthy adults

You may not qualify if:

• Antibiotic use within the last 3 months, identified gastro-intestinal diseases, on prescribed medication other than the contraceptive pill, individuals who are pregnant or breastfeeding. Individuals who have been diagnosed as anaemic, as well as those who are allergic to any food, or paracetamol.

Sponsors & Collaborators

• University of Glasgow: lead
• Scottish Universities Environmental Research Centre: collaborator

Study Sites (1)

School of Medicine, Nursing and Dentistry, College of MVLS, University of Glasgow

Glasgow, Lanarkshire, G31 2ER, United Kingdom

Location

Related Publications (5)

• Russell W, Duthie G. Plant secondary metabolites and gut health: the case for phenolic acids. Proc Nutr Soc. 2011 Aug;70(3):389-96. doi: 10.1017/S0029665111000152.

  PMID: 21781364 BACKGROUND

• Roowi S, Mullen W, Edwards CA, Crozier A. Yoghurt impacts on the excretion of phenolic acids derived from colonic breakdown of orange juice flavanones in humans. Mol Nutr Food Res. 2009 May;53 Suppl 1:S68-75. doi: 10.1002/mnfr.200800287.

  PMID: 19415668 BACKGROUND

• Henning SM, Wang P, Abgaryan N, Vicinanza R, de Oliveira DM, Zhang Y, Lee RP, Carpenter CL, Aronson WJ, Heber D. Phenolic acid concentrations in plasma and urine from men consuming green or black tea and potential chemopreventive properties for colon cancer. Mol Nutr Food Res. 2013 Mar;57(3):483-93. doi: 10.1002/mnfr.201200646. Epub 2013 Jan 14.

  PMID: 23319439 BACKGROUND

• Czank C, Cassidy A, Zhang Q, Morrison DJ, Preston T, Kroon PA, Botting NP, Kay CD. Human metabolism and elimination of the anthocyanin, cyanidin-3-glucoside: a (13)C-tracer study. Am J Clin Nutr. 2013 May;97(5):995-1003. doi: 10.3945/ajcn.112.049247.

  PMID: 23604435 BACKGROUND

• Morrison DJ, O'Hara JP, King RF, Preston T. Quantitation of plasma 13C-galactose and 13C-glucose during exercise by liquid chromatography/isotope ratio mass spectrometry. Rapid Commun Mass Spectrom. 2011 Sep 15;25(17):2484-8. doi: 10.1002/rcm.5139.

  PMID: 21818809 BACKGROUND

MeSH Terms

Interventions

Inulin

Intervention Hierarchy (Ancestors)

Starch; Glucans; Biopolymers; Polymers; Macromolecular Substances; Dietary Carbohydrates; Carbohydrates; Fructans; Polysaccharides

Study Officials

• Prof. Edwards

  University of Glasgow

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Model Details: Acute human bioavailability studies with a cross-over design will be given to subjects in the form of a drink in one of three combinations 1. Strawberry juice alone 2. Inulin alone 3. Mixture of strawberry juice and inulin

Study Record Dates

• First Submitted: December 19, 2017
• First Posted: December 26, 2017
• Study Start: April 28, 2017
• Primary Completion: July 6, 2019
• Study Completion: July 6, 2019
• Last Updated: July 12, 2019

Record last verified: 2019-07

Locations

GB (1)