Spermidine Intake and All-cause Mortality

NCT03378843 | Completed

• 1 other identifier: Bruneck_2017_Spermidine
• Study Type: observational
• Target: 829
• Locations: 0 countries
• Sites: N/A

Brief Summary

This study seeks to test the potential association between spermidine content in diet and mortality in humans.

Conditions

Healthy Diet; Mortality

Keywords

Polyamine, cardiovascular disease, cancer

Outcome Measures

Primary Outcomes (1)

• All-cause mortality

  Death due to any cause

  1995-2015

Secondary Outcomes (1)

• Cause-specific mortalities

  1995-2015

Interventions

Spermidine content of natural diet OTHER

The exposure consists in the long-term average dietary intake of the polyamine spermidine

Eligibility Criteria

• Age: 45 Years - 84 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

A random sample intended to represent the general population, recruited in 1990.

You may qualify if:

• Resident of Bruneck aged 40-79 years in 1990, age- and sex-stratified random sample.

Sponsors & Collaborators

• Medical University Innsbruck: lead
• Krankenhaus Bruneck: collaborator
• University of Graz: collaborator
• Paracelsus Medical University: collaborator
• Institut National de la Santé Et de la Recherche Médicale, France: collaborator
• King's College London: collaborator
• Universitaet Innsbruck: collaborator

Related Publications (4)

• Kiechl S, Lorenz E, Reindl M, Wiedermann CJ, Oberhollenzer F, Bonora E, Willeit J, Schwartz DA. Toll-like receptor 4 polymorphisms and atherogenesis. N Engl J Med. 2002 Jul 18;347(3):185-92. doi: 10.1056/NEJMoa012673.

  PMID: 12124407 BACKGROUND

• Stegemann C, Pechlaner R, Willeit P, Langley SR, Mangino M, Mayr U, Menni C, Moayyeri A, Santer P, Rungger G, Spector TD, Willeit J, Kiechl S, Mayr M. Lipidomics profiling and risk of cardiovascular disease in the prospective population-based Bruneck study. Circulation. 2014 May 6;129(18):1821-31. doi: 10.1161/CIRCULATIONAHA.113.002500. Epub 2014 Mar 12.

  PMID: 24622385 BACKGROUND

• Pechlaner R, Tsimikas S, Yin X, Willeit P, Baig F, Santer P, Oberhollenzer F, Egger G, Witztum JL, Alexander VJ, Willeit J, Kiechl S, Mayr M. Very-Low-Density Lipoprotein-Associated Apolipoproteins Predict Cardiovascular Events and Are Lowered by Inhibition of APOC-III. J Am Coll Cardiol. 2017 Feb 21;69(7):789-800. doi: 10.1016/j.jacc.2016.11.065.

  PMID: 28209220 BACKGROUND

• Kiechl S, Pechlaner R, Willeit P, Notdurfter M, Paulweber B, Willeit K, Werner P, Ruckenstuhl C, Iglseder B, Weger S, Mairhofer B, Gartner M, Kedenko L, Chmelikova M, Stekovic S, Stuppner H, Oberhollenzer F, Kroemer G, Mayr M, Eisenberg T, Tilg H, Madeo F, Willeit J. Higher spermidine intake is linked to lower mortality: a prospective population-based study. Am J Clin Nutr. 2018 Aug 1;108(2):371-380. doi: 10.1093/ajcn/nqy102.

  PMID: 29955838 DERIVED

MeSH Terms

Conditions

Cardiovascular Diseases; Neoplasms

Study Officials

• Stefan Kiechl, MD

  Medical University of Innsbruck

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: A.Univ.-Prof. Dr.

Study Record Dates

• First Submitted: December 14, 2017
• First Posted: December 20, 2017
• Study Start: October 1, 1995
• Primary Completion: October 1, 2015
• Study Completion: October 1, 2015
• Last Updated: December 20, 2017

Record last verified: 2017-12

Data Sharing

• IPD Sharing: Will not share