Impact of Sprint Stair Climbing "Snacks" on Markers of Metabolism and Vascular Function

NCT03374436 | Completed

• 1 other identifier: H17-01747
• Study Type: interventional
• Target: 23
• Locations: 1 country
• Sites: 1

Brief Summary

Prolonged sitting has been shown to impair metabolism and vascular function. The overall purpose of this study is to determine if breaking up prolonged (9 hours) of sitting with brief (\~20 second) stair climbing exercise "snacks" can improve markers of metabolic control and vascular health in healthy young male participants and in males or females with overweight/obesity who are at risk of insulin resistance. An additional purpose is to determine if saliva insulin can be used as a valid indicator of blood insulin when measured throughout the day in sedentary and active conditions and when diets with different amounts of carbohydrates are consumed.

Conditions

Physical Activity; Diet Modification

Outcome Measures

Primary Outcomes (1)

• Plasma insulin area under the curve

  The plasma insulin concentration measured by enzyme-linked immunosorbent assay area under the curve will be measured using the trapezoidal rule.

  Measured across 9 hours of each intervention day

Secondary Outcomes (7)

• Saliva insulin area under the curve

  Measured across 9 hours of each intervention day

• Plasma glucose area under the curve

  Measured across 9 hours of each intervention day

• Plasma triglyceride area under the curve

  Measured across 9 hours of each intervention day

• Plasma non-esterified fatty acids area under the curve

  Measured across 9 hours of each intervention day

• Femoral artery flow-mediated dilation

  Measured in the morning (time 0 hours) and afternoon (time 8.5 hours) each intervention day

Study Arms (3)

High-Carbohydrate Sedentary

EXPERIMENTAL

Participants will remain seated for 9 hours (except for using the restroom) while consuming a high-carbohydrate diet (3 meals)

Behavioral: High-Carbohydrate Sedentary

High-Carbohydrate Active

EXPERIMENTAL

Participants will remain seated for 9 hours (except for using the restroom) while consuming a high-carbohydrate diet (3 meals) but will complete 8 stair climbing sprint "snacks" once per hour involving ascending 3 flights of stairs at a vigorous pace (\~20 seconds each).

Behavioral: High-Carbohydrate Active

Low-Carbohydrate Sedentary

ACTIVE COMPARATOR

Participants will remain seated for 9 hours (except for using the restroom) while consuming a low-carbohydrate diet (3 meals)

Behavioral: Low-carbohydrate Sedentary

Interventions

High-Carbohydrate Sedentary BEHAVIORAL

Three high-carbohydrate meals will be consumed (breakfast, lunch, and dinner) at \~3 hour intervals while participants remain in a seated position for the entire 9 hour intervention period.

High-Carbohydrate Sedentary

High-Carbohydrate Active BEHAVIORAL

Three high-carbohydrate meals will be consumed (breakfast, lunch, and dinner) at \~3 hour intervals while participants remain in a seated position for the entire 9 hour intervention period except that once every hour they will ascend three flights of stairs vigorously (stair climbing sprint "snack") for a total of 8 active breaks.

High-Carbohydrate Active

Low-carbohydrate Sedentary BEHAVIORAL

Three low-carbohydrate meals will be consumed (breakfast, lunch, and dinner) at \~3 hour intervals while participants remain in a seated position for the entire 9 hour intervention period. This condition will provide a condition where the blood glucose and insulin responses are relatively low and stable throughout the day.

Low-Carbohydrate Sedentary

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Non-smoking

You may not qualify if:

• Diagnosed with diabetes or prediabetes (fasting blood sugar more than 6.0 mmol/l) or any other chronic condition that may impact glucose or insulin levels.
• BMI is over 25 kg/m2 Take medications which may affect glucose and insulin levels Allergic to eggs. Smoker Competitive or serious endurance athlete.
• Elevated waist circumference (\>102 cm for male and \>88 cm for female)
• Diagnosed with diabetes (fasting blood sugar more than 7.0 mmol/l) Take medications which may affect glucose and insulin levels Allergic to eggs. Smoker Competitive or serious endurance athlete.

Sponsors & Collaborators

• University of British Columbia: lead
• Mitacs: collaborator
• CoreHealth Technologies Inc.: collaborator

Study Sites (1)

University of British Columbia Okanagan

Kelowna, British Columbia, V1V 3G1, Canada

Location

Related Publications (2)

• Rafiei H, Omidian K, Chang CR, Little JP. Saliva insulin tracks plasma insulin across the day following high-carbohydrate and low-carbohydrate meals. Appl Physiol Nutr Metab. 2023 Sep 1;48(9):700-709. doi: 10.1139/apnm-2023-0066. Epub 2023 Jun 1.

  PMID: 37262929 DERIVED

• Caldwell HG, Coombs GB, Rafiei H, Ainslie PN, Little JP. Hourly staircase sprinting exercise "snacks" improve femoral artery shear patterns but not flow-mediated dilation or cerebrovascular regulation: a pilot study. Appl Physiol Nutr Metab. 2021 May;46(5):521-529. doi: 10.1139/apnm-2020-0562. Epub 2020 Nov 26.

  PMID: 33242251 DERIVED

MeSH Terms

Conditions

Motor Activity

Condition Hierarchy (Ancestors)

Behavior

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Masking Details: It is not possible to mask the exercise or diet interventions.
• Purpose: OTHER
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Model Details: Participants complete three conditions in a repeated crossover design.

Study Record Dates

• First Submitted: December 11, 2017
• First Posted: December 15, 2017
• Study Start: October 1, 2017
• Primary Completion: June 30, 2019
• Study Completion: August 30, 2019
• Last Updated: September 25, 2019

Record last verified: 2019-09

Locations

CA (1)