Predictors and Outcomes of In-hospital HFpEF in AMI Patients

NCT03351179 | Unknown

• 1 other identifier: FirstSoochowU
• Study Type: observational
• Target: 500
• Locations: 1 country
• Sites: 1

Brief Summary

This retrospective observation is to investigate the incidence,clinical outcomes and prognosis of hospitalized heart failure with preserved ejection fraction (HFpEF) in patients with acute myocardial infarction(AMI).

Conditions

Acute Myocardial Infarction; Heart Failure With Preserved Ejection Fraction; Predictor; Prognosis

Keywords

Heart Failure with Preserved Ejection Fraction; Acute MyocAcute Myocardial Infarction; Predictive factors

Outcome Measures

Primary Outcomes (1)

• Risk factors of incident in-hospital HFpEF

  Outcome measure will be assessed at discharge, and data will be reported through study completion, an average of 1 year.

Secondary Outcomes (1)

• Clinical prognosis in patients with HFpEF

  Outcome measure will be assessed at discharge, and data will be reported through study completion, an average of 1 year.

Study Arms (2)

AMI patients with HFpEF

Combination Product: clinical characteristics, previous history, laboratory bio-markers, echocardiographic measurements, angiographic findings,clinical outcomes

AMI patients without HF

Combination Product: clinical characteristics, previous history, laboratory bio-markers, echocardiographic measurements, angiographic findings,clinical outcomes

Interventions

clinical characteristics, previous history, laboratory bio-markers, echocardiographic measurements, angiographic findings,clinical outcomes COMBINATION_PRODUCT

The differences of data(clinical characteristics, history, laboratory biomarkers, echocardiographic measurements, angiographic characteristics and clinical outcomes) in two groups were conducted. The differences between two groups were compared (clinical characteristics, history, laboratory biomarkers, echocardiographic measurements, angiographic characteristics and clinical outcomes) in two groups were compared, and then found the risk factors. Following,the incidence of clinical outcomes and mortality were compared. Then, univariate logistic regression and multivariate logistic regression analysis adjusted for significant risk factors were performed to find out the independent predictive factors. Finally, the ROC was constructed, and the area was evaluated to assess the predicted probability of regression model.

AMI patients with HFpEF; AMI patients without HF

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

AMI patients with HFpEF: First AMI subjects undergoing PCI with a diagnosis of HFpEF. AMI patients without HF: First AMI subjects undergoing PCI without a diagnosis of HF.

You may qualify if:

• First AMI patients undergoing PCI with HFpEF or without HF.

You may not qualify if:

• First AMI patients with heart failure with reduced ejection fraction.
• First AMI patients with severe inflammatory diseases, valvular heart disease, non-cardiac caused symptoms, serious hepatic and renal failure, congenital cardiomyopathy,or pericardial diseases.

Sponsors & Collaborators

• Xiangjun Yang: lead

Study Sites (1)

the First Affiliated Hospital of Soochow University

Suzhou, Jiangsu, 215006, China

Location

Study Officials

• Xiangjun Yang, PhD

  First Affiliated Hospital of Soochow University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Director, department of cardiology

Study Record Dates

• First Submitted: November 4, 2017
• First Posted: November 22, 2017
• Study Start: January 1, 2013
• Primary Completion: December 30, 2018
• Study Completion: December 30, 2018
• Last Updated: January 2, 2019

Record last verified: 2018-12

Locations

CN (1)