The Prognosis of Acute Myocardial Infarction

NCT02737956 | Completed DMC

• 1 other identifier: 20160317-03
• Study Type: observational
• Target: 7,350
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to establish a registry and surveillance system for acute myocardial infarction (AMI) patients in Xinjiang, focusing on collecting comprehensive information including basic patient demographics, patient characteristics, diagnostic methods, treatment programs, and hospitalization outcomes such as mortality, treatment complications, hospitalization costs, and follow-up events (death, major adverse cardiac events). The goal is to identify and propose effective prevention strategies to reduce the incidence of AMI, optimize the management and outcomes of AMI patients by implementing guideline recommendations in clinical practice, and conduct analyses to develop effective treatment strategies and predictive models for clinical outcomes. This focus on Xinjiang aims to provide a comprehensive understanding of AMI within this specific geographic and demographic context, ultimately contributing to improved prevention, treatment, and management of AMI patients.

Conditions

Acute Myocardial Infarction

Outcome Measures

Primary Outcomes (1)

• Death

  All-cause mortality, Cardiac mortality

  5 years

Secondary Outcomes (3)

• Major adverse cardiovascular events (MACE)

  5 years

• Major adverse cardiovascular and cerebrovascular events (MACCE)

  5 years

• stroke

  5 years

Study Arms (2)

AMI patients with treatment of PCI

All the patiets treat with PCI were enrolled and recorded the clinical characteristic and outcomes during the follow-up period.

Medication

All the patiets treat with medication (standard secondary prevention) without PCI were enrolled and recorded the clinical characteristic and outcomes during the follow-up period.

Eligibility Criteria

• Age: 18 Years - 79 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

The study population consists of acute myocardial infarction (AMI) patients hospitalized at the First Affiliated Hospital of Xinjiang Medical University. This includes individuals diagnosed with both acute ST-elevation myocardial infarction (STEMI) and non-ST-elevation myocardial infarction (NSTEMI).

You may qualify if:

• Acute myocardial infarction patients in hospitalized of the First Affiliated Hospital of Xinjiang Medical University (include diagnosed acute ST-elevation or non ST-elevation myocardial infarction).Diagnosis criteria must meet Universal Definition for AMI (2012).

You may not qualify if:

• Combined with severe valvular heart disease;
• Combined with severe congenital heart disease;
• Combined hyperthyroidism, anemia and other high-powered heart disease;
• With pulmonary heart disease;
• With hypertrophic obstructive cardiomyopathy;
• Severe hypotension (SBP \<90mmHg or DBP \<60mmHg at enrollment);
• Uncontrolled hypertension (SBP\> 160 mmHg before PCI, and / or DBP\> 100 mmHg);
• Liver dysfunction (defined as ALT or total bilirubin is greater than the normal upper limit of 3 times);
• Renal insufficiency (defined as serum creatinine greater than 1.5 times the normal upper limit);
• High-risk bleeding patients, such as thrombocytopenia, blood diseases and other diseases;
• active peptic ulcer and skin ulcers;
• A patient who is allergic to clopidogrel, tegrellol, or aspirin;
• Patients with a history of cardiogenic shock within two weeks;
• pregnant and lactating women, during treatment can not be strict contraception of women of childbearing age;
• In the past 3 months participated in other clinical researchers;

Sponsors & Collaborators

• Xinjiang Medical University: lead

Study Sites (1)

First Affilliatted Hospital of Xinjiang Medical University

Ürümqi, Xinjiang, 830011, China

Location

Related Publications (2)

• Yan J, Deng CJ, Wang SF, Aimaitijiang M, Wu TT, Zheng YY, Xie X, Ma YT. Predictive Value of the Modified GRACE Scoring System for All-Cause Mortality in Patients with Acute Myocardial Infarction. Rev Cardiovasc Med. 2023 Jun 6;24(6):161. doi: 10.31083/j.rcm2406161. eCollection 2023 Jun.

  PMID: 39077519 DERIVED

• Xiu WJ, Yang HT, Zheng YY, Ma YT, Xie X. Delayed PCI 12 Hours after the Onset of Symptoms Is Associated with Improved Outcomes for Patients with ST-Segment Elevation Myocardial Infarction: A Real-World Study. J Interv Cardiol. 2019 Jun 18;2019:2387929. doi: 10.1155/2019/2387929. eCollection 2019.

  PMID: 31772517 DERIVED

Study Officials

• Xiang Xie, PhD

  Xinjiang Medical University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Xiangxie, MD,Professor, The First Affiliated Hospital Of XinJiang Medicial University

Study Record Dates

• First Submitted: April 5, 2016
• First Posted: April 14, 2016
• Study Start: June 1, 2012
• Primary Completion: May 31, 2016
• Study Completion: December 10, 2023
• Last Updated: March 28, 2024

Record last verified: 2024-03

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)