Risk Factors In Heart Failure Patients With Preserved Ejection Fraction

NCT06487468 | Completed

• 1 other identifier: 2024/6
• Study Type: observational
• Target: 9,419
• Locations: 0 countries
• Sites: N/A

Brief Summary

This study aimed to identify the independent risk factors associated with heart failure readmission, cardiac mortality and all-cause death among patients discharged from Xiangtan Central Hospital with heart failure and preserved ejection fraction (HFpEF). Understanding related risk factors might add future clinical decision making for individualized post discharge management of HFpEF patients aiming to improve the outcome of discharged HFpEF patients.

Conditions

Heart Failure With Preserved Ejection Fraction

Keywords

HFpEF, Outcome

Outcome Measures

Primary Outcomes (1)

• All-cause death（people）

  Risk factors of all-cause death are analyzed（Increase the factors that contribute to the occurrence of endpoint events）

  The patients are clinically followed up until January 31, 2024, per clinical visit or telephone call or community visit.

Secondary Outcomes (1)

• Cardiovascular death and Heart failure readmission（people）

  The patients are clinically followed up until January 31, 2024, per clinical visit or telephone call or community visit.

Study Arms (1)

HFpEF Group

HFpEF (Heart failure with preserved ejection fraction): LVEF≥50%. Non-endpoint events group versus Endpoint events (all-cause death,cardiovascular death or heart failure readmission) group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients who hospitalized the Xiangtan Central Hospital between May 1, 2014, and January 31, 2023, with the diagnosis of heart failure and met HFpEF criteria at final analysis.

You may qualify if:

• Patients discharged with diagnosis of heart failure were screened and met definition of heart failure with preserved ejection fraction (HFpEF) according to the 2021 European Society of Cardiology (ESC) guidelines at final analysis.
• ）Heart failure signs and symptoms; 2）LVEF\>50%;

You may not qualify if:

• \) age under 18 years; 2) life expectancy of less than one year due to non-cardiac conditions.

Sponsors & Collaborators

• Xiangtan Central Hospital: lead

Related Publications (1)

• Zhu Y, Zhao W, Liu Z, Tan D, Tao L, He W, Jiang K, Huang H, Wu M, Tang L, Zeng J, Zhou S. Development and validation of a prediction model for all-cause death in heart failure patients with preserved ejection fraction: a single-centre cohort study in China. BMJ Open. 2025 Sep 10;15(9):e094909. doi: 10.1136/bmjopen-2024-094909.

  PMID: 40935414 DERIVED

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Director of Cardiovascular Department of Xiangtan Central Hospital,Clinical Professor

Study Record Dates

• First Submitted: June 27, 2024
• First Posted: July 5, 2024
• Study Start: May 1, 2014
• Primary Completion: January 31, 2023
• Study Completion: January 31, 2024
• Last Updated: July 8, 2024

Record last verified: 2024-07