Prevalence and Clinical Characteristics of Patients With Jackhammer Esophagus and Symptoms of Gastroesophageal Reflux Disease

NCT03347903 | Completed

• 1 other identifier: 1164/2017
• Study Type: observational
• Target: 37
• Locations: 0 countries
• Sites: N/A

Brief Summary

Gastroesophageal reflux disease (GERD) is involved in the development of esophageal motility disorders like Jackhammer esophagus (JE), a novel hypercontractile condition that was associated with progression to achalasia and limited outcomes following surgical anti-reflux therapy. This trial was designed to assess the prevalence and characteristics of JE in patients with typical symptoms of GERD and responsiveness to PPI therapy.

Conditions

Esophageal Motility Disorders

Keywords

esophagus; motility

Outcome Measures

Primary Outcomes (1)

• Prevalence of Jackhammer esophagus in patients referred with symptoms of gastroesophageal reflux disease

  All patients that are referred to our center with symptoms of gastroesophageal reflux disease routinely undergo high-resolution manometry. We assess how many patients are diagnosed with Jackhammer esophagus

  January 2014- May 2017

Secondary Outcomes (2)

• Symptom perception

  January 2014- May 2017

• Prevalence of gastroesophageal reflux disease in patients with Jackhammer esophagus

  Januar 2014- May 2017

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

All patients that are referred to our center undergo esophageal high-resolution manometry and ambulatory pH monitoring for screening of gastroesophageal reflux disease and motility disorders. We assess the data that are prospectively obtained. Patients do not have to undergo any interventions.

You may qualify if:

• Patients with symptoms of gastroesophageal reflux disease and diagnosis of Jackhammer esophagus

You may not qualify if:

• patients not willing to participate data or undergo screening for gastroesophageal reflux disease

Sponsors & Collaborators

• Medical University of Vienna: lead

Related Publications (1)

• Kristo I, Schwameis K, Maschke S, Kainz A, Rieder E, Paireder M, Jomrich G, Schoppmann SF. Phenotypes of Jackhammer esophagus in patients with typical symptoms of gastroesophageal reflux disease responsive to proton pump inhibitors. Sci Rep. 2018 Jul 2;8(1):9949. doi: 10.1038/s41598-018-27756-9.

  PMID: 29967357 DERIVED

MeSH Terms

Conditions

Esophageal Motility Disorders

Condition Hierarchy (Ancestors)

Deglutition Disorders; Esophageal Diseases; Gastrointestinal Diseases; Digestive System Diseases

Study Officials

• Sebastian Schoppmann, MD

  Vice Chair of Department of General Surgery

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dr. med. univ.

Study Record Dates

• First Submitted: November 15, 2017
• First Posted: November 20, 2017
• Study Start: January 1, 2014
• Primary Completion: May 30, 2017
• Study Completion: May 30, 2017
• Last Updated: November 21, 2017

Record last verified: 2017-11