The Clinical Manifestation and Prognosis of Pediatric Esophageal Motility Disorders

NCT06629025 | Completed

• 1 other identifier: 202302017RIND
• Study Type: observational
• Target: 10
• Locations: 1 country
• Sites: 1

Brief Summary

Background: Abnormal esophageal peristalsis mostly occurs in adults, but some patients have onset in childhood. Most of the symptoms of esophageal motility disorders in children are not as clear as those described by adult patients, and they are only manifested in repeated vomiting. Esophageal peristalsis abnormalities in children took longer from symptoms to diagnosis than in adults. Common esophageal motility disorders in children include Achalasia, ineffective esophageal motility disorder (IEM), absent contractility, nutcracker esophagus, jackhammer esophagus, diffuse Esophageal spasm (diffuse esophageal spasm), lower esophageal sphincter hypertension (hypertensive lower esophageal sphincter), etc. Treatment for abnormal esophageal motility includes medication, endoscopic therapy, and surgery. This includes peroral endoscopic myotomy (POEM). The above treatment effects are rarely reported in children. This project uses the method of retrospective analysis of medical records to study the clinical manifestations and treatment prognosis of abnormal esophageal motility in children Research purpose: The purpose of this study is to evaluate various clinical manifestations and treatment prognosis of abnormal esophageal motility in children, including analysis of diagnosis age, symptom time, related imaging examinations, endoscopy and high-resolution esophageal pressure examination, treatment methods, etc. Research design: We plan to collect pediatric patients (0-20 years old) diagnosed with abnormal esophageal peristalsis at National Taiwan University Hospital during 2010/1/1-2022/12/31. Retrospective analysis of medical records and relevant laboratory data of patients in hospitals, including gender, height and weight, age of onset, symptoms, clinical manifestations, endoscopy, gastrointestinal photography, 24-hour multi-lumen esophageal impedance and acid-base examination, high-resolution esophageal pressure examination, ultrasound examination, pathological slide report, treatment response, etc. Expected results: Analyze the clinical symptoms and different treatment methods of abnormal esophageal motility in children, and understand the development and prognosis of abnormal esophageal motility in children. Key words: Esophageal motility disorders in children; High-resolution esophageal manometry; Esophageal achalasia

Conditions

Esophageal Motility Disorders

Keywords

Esophageal achalasia; High-resolution esophageal manometry; Esophageal motility disorders in children

Outcome Measures

Primary Outcomes (3)

• Treatment success rate of esophageal motility disorders

  up to 10 years

• Number of Patients with Serious and Non-Serious Adverse Events

  up to 4 weeks

• Time to Disease Progression

  up to 10 years

Study Arms (1)

esophageal motility disorder

Pediatric patients (0-20 years old) with clinically diagnosed abnormal esophageal motility

Diagnostic Test: High-resolution impedance manometry

Interventions

High-resolution impedance manometry DIAGNOSTIC_TEST

High-resolution impedance manometry (HRIM) can calculate the bolus motion parameters and the ratio of complete esophageal transit

Also known as: Peroral endoscopic myotomy (POEM)

esophageal motility disorder

Eligibility Criteria

• Age: 0 Years - 20 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Probability Sample

Study Population

We plan to collect pediatric patients (0-20 years old) diagnosed with esophageal motility disorders at National Taiwan University Hospital during 2010/1/1-2022/12/31.

You may qualify if:

• Pediatric patients (0-20 years old) who have been clinically diagnosed with esophageal motility disorders

You may not qualify if:

• Exclude the diagnosis of esophageal motility disorders

Sponsors & Collaborators

• National Taiwan University Hospital: lead

Study Sites (1)

National Taiwan University Children's Hospital

Taipei, Taiwan

Location

MeSH Terms

Conditions

Esophageal Motility Disorders; Esophageal Achalasia

Condition Hierarchy (Ancestors)

Deglutition Disorders; Esophageal Diseases; Gastrointestinal Diseases; Digestive System Diseases

Study Officials

• Chienting Hsu

  17F, No. 8, Chung-Shan South Rd, Taipei 100, Taiwan

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 3, 2024
• First Posted: October 8, 2024
• Study Start: March 15, 2023
• Primary Completion: February 5, 2024
• Study Completion: February 5, 2024
• Last Updated: October 8, 2024

Record last verified: 2023-03

Locations

TW (1)