Exercise for Adults With Parkinson Disease

NCT02615548 | Unknown DMC

• 1 other identifier: H15-01772
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

Physical activity is a key intervention used to reduce the healthcare costs and the negative consequences of Parkinson Disease (PD) by improving walking and balance and reducing the number of falls. However, not all exercise classes provide the same results for people with PD. Specific exercises designed to target the features of PD have shown greater outcomes than generic physical activity. The exercise principles include high-intensity (size and speed) movement, task repetition, rhythmical rocking, mental imagery, cognitive strategies, treadmill walking, and making use of internal and external cues. Collectively these PD-specific exercises can be designed to be run in exercise groups. Structured exercise groups also include social interaction that is known to improve depression and apathy, both of which are features common in people with PD. This study will compare the effect of specific, long-term community-based exercise class on balance, walking, quality of life, and mood compare to self-directed exercise. Investigators anticipate that participants from the community-based, long-term intervention will show better improvements in balance and walking compare to participants that are self-directing their activities.

Conditions

Parkinson Disease

Keywords

exercises

Outcome Measures

Primary Outcomes (1)

• . Functional Gait Assessment (FGA)

  FGA is a 10-item test, assessing walking and balance.It is well validated as a predictor for falls for people with PD

  Assess the change between baseline and post 9-month intervention.

Secondary Outcomes (2)

• 6 minute walk test (6MWT)-

  Assess the change between baseline and post 9-month intervention.

• Semi-structured interview

  Assess the change between baseline and post 9-month intervention.

Study Arms (2)

Community exercise class

EXPERIMENTAL

Regular community exercise class is the intervention. It is an exercise class that incorporate PWR moves( UP,ROCK,STEP,TWIST) and cardiovascular training.

Other: community-based exercise class

self-directed exercise activity

ACTIVE COMPARATOR

Self-directed exercise.

Other: self-directed physical activity

Interventions

community-based exercise class OTHER

This intervention will be held in a community centre, twice per week, for 36 weeks.The participants will have an educational session regarding importance of regular exercise.The class will consist of evidence-based exercises such as: sustained, high effort exercises, resistance exercises, and endurance training.Two trainers with specific for Parkinson Disease training will lead the class.

Community exercise class

self-directed physical activity OTHER

Participants from this group will have an educational session regarding importance of regular exercises for Parkinson Disease and will be asked to stay as active as possible.Both groups will be asked to fill out physical activity diary.

self-directed exercise activity

Eligibility Criteria

• Age: 45 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Idiopathic PD
• Hoehn \& Yahr stages 1 to 3 (17).These stages define early to mid-stage of PD.
• Adult men and/or women, age 45-80
• Willing and able to participate in 60-minute of physical activity, 3/week for 12-weeks, then 2/week for 36 weeks

You may not qualify if:

• History of any neurological, cardiovascular, or orthopedic condition that can limit their ability to participate
• Individuals who self-report engaging in more than 120 minutes of vigorous physical activity per week at baseline

Sponsors & Collaborators

• University of British Columbia: lead
• Vancouver Coastal Health: collaborator

Study Sites (1)

Lions Gate Hospital

North Vancouver, British Columbia, V7M 1P4, Canada

Location

Related Publications (2)

• Ernst M, Folkerts AK, Gollan R, Lieker E, Caro-Valenzuela J, Adams A, Cryns N, Monsef I, Dresen A, Roheger M, Eggers C, Skoetz N, Kalbe E. Physical exercise for people with Parkinson's disease: a systematic review and network meta-analysis. Cochrane Database Syst Rev. 2024 Apr 8;4(4):CD013856. doi: 10.1002/14651858.CD013856.pub3.

  PMID: 38588457 DERIVED

• Ernst M, Folkerts AK, Gollan R, Lieker E, Caro-Valenzuela J, Adams A, Cryns N, Monsef I, Dresen A, Roheger M, Eggers C, Skoetz N, Kalbe E. Physical exercise for people with Parkinson's disease: a systematic review and network meta-analysis. Cochrane Database Syst Rev. 2023 Jan 5;1(1):CD013856. doi: 10.1002/14651858.CD013856.pub2.

  PMID: 36602886 DERIVED

MeSH Terms

Conditions

Parkinson Disease; Motor Activity

Condition Hierarchy (Ancestors)

Parkinsonian Disorders; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases; Behavior

Study Officials

• Diana Krasteva, Bachelor's

  Vancouver Coastal Health/ University of British Columbia

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: SUPPORTIVE CARE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Physiotherapist

Study Record Dates

• First Submitted: November 23, 2015
• First Posted: November 26, 2015
• Study Start: March 1, 2016
• Primary Completion: July 1, 2017
• Study Completion: December 1, 2017
• Last Updated: November 22, 2016

Record last verified: 2016-11

Locations

CA (1)