NCT03337139

Brief Summary

Most adults in the U.S. are overweight or obese and find maintenance of weight loss difficult. This study is designed to aid in the development of a lifestyle modification program that can facilitate weight loss maintenance, without requiring long-term visits to a clinic for maintenance treatment.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
87

participants targeted

Target at P50-P75 for not_applicable obesity

Timeline
Completed

Started Nov 2017

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

November 7, 2017

Completed
1 day until next milestone

First Posted

Study publicly available on registry

November 8, 2017

Completed
9 days until next milestone

Study Start

First participant enrolled

November 17, 2017

Completed
1.5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 31, 2019

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

May 31, 2019

Completed
1.6 years until next milestone

Results Posted

Study results publicly available

January 5, 2021

Completed
Last Updated

January 5, 2021

Status Verified

December 1, 2020

Enrollment Period

1.5 years

First QC Date

November 7, 2017

Results QC Date

October 30, 2020

Last Update Submit

December 10, 2020

Conditions

Keywords

Weight LossObesityOverweightBehavioral Weight Loss

Outcome Measures

Primary Outcomes (5)

  • Change in Body Weight

    Objectively measured in the research clinic at each time point on a scale. Reported as weight change in kg, where negative numbers reflect weight loss and positive numbers reflect weight gain.

    0, 13, 26, 52 weeks

  • Change in Physical Activity

    Objectively measured using wGT3X-BT accelerometers from Actigraph. Minutes/week of moderate-to-vigorous physical activity (MVPA).

    13, 52 weeks

  • Number of Participants Retained

    Feasibility and acceptability metric of retention.

    26, 52 weeks

  • Number of Completed Treatment Contacts

    Feasibility and acceptability metric of completed treatment contacts (phone calls and text messages).

    52 weeks

  • Treatment Acceptability Questionnaire (TAQ)

    Feasibility and acceptability metric of scores on the TAQ. Items on the TAQ consisted of 11 questions on a 7 point Likert scale asking about helpfulness and acceptability of treatment components. Items are summed to yield a total score that can range from 11-77 with higher numbers indicated higher acceptability.

    52 weeks

Secondary Outcomes (2)

  • Self-monitoring Engagement

    13-52 weeks

  • Perceived Accountability

    52 weeks

Study Arms (2)

Lifestyle Modification

ACTIVE COMPARATOR

Three months of standard, group-based behavioral treatment for weight loss and nine months of remote individual behavioral treatment based on self-report.

Behavioral: Gold Standard Behavior Therapy for Weight LossBehavioral: Standard Remote Behavior Therapy for Weight Loss

Lifestyle Modification + Share

EXPERIMENTAL

Three months of standard, group-based behavioral treatment for weight loss and nine months of remote individual behavioral treatment based on digital data shared with clinicians.

Behavioral: Gold Standard Behavior Therapy for Weight LossBehavioral: Digital Data Sharing Behavior Therapy for Weight Loss

Interventions

Group-based behavioral treatment for weight loss, with a standard emphasis on diet (65% of session) and physical activity goals (25% of session). Other weight loss behaviors such as self monitoring will be covered in the remaining time (10% of session). Participants will be asked to utilize digital monitoring devices for physical activity, weight, and diet. Coaches will not have access to the digital data that participants provide on physical activity, weight, and diet monitoring devices.

Lifestyle ModificationLifestyle Modification + Share

Individual, monthly, brief phone calls with coach and weekly text messages. The content of these calls and messages will be determined by participant self-report. Coaches will not have access to the digital data that participants provide on physical activity, weight, and diet monitoring devices.

Lifestyle Modification

Individual, monthly, brief phone calls with coach and weekly text messages. The content of these calls and messages will be determined by the digital data that has been shared with the coach from physical activity, weight, and diet monitoring devices.

Lifestyle Modification + Share

Eligibility Criteria

Age18 Years - 70 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Adults aged 18-70 years with a BMI of 25-45 kg/m2 and weight \<160 kg
  • Access to a smartphone
  • Satisfactory completion of all enrollment procedures
  • Ability to engage in physical activity (i.e. can walk at least 2 blocks without stopping for rest)

You may not qualify if:

  • Medical condition (i.e. acute coronary syndrome, type 1 diabetes, renal failure) or psychiatric condition (i.e. active substance abuse, eating disorder) that may:
  • Pose a risk to the participant during the intervention
  • Cause a change in weight
  • Limit ability to comply with the behavioral recommendations of the program
  • Pregnant or planning pregnancy in the next 1 year
  • Planned move out of the Philadelphia area during the data collection period
  • Use of a pacemaker (incompatible with wireless scale technology)
  • Recently began or changed the dosage of a medication that can cause significant change in weight
  • History of bariatric surgery
  • Weight loss of \> 10% in the previous 3 months

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Drexel University

Philadelphia, Pennsylvania, 19104, United States

Location

Related Publications (2)

  • Butryn ML, Martinelli MK, Crane NT, Godfrey K, Roberts SR, Zhang F, Forman EM. Counselor Surveillance of Digital Self-Monitoring Data: A Pilot Randomized Controlled Trial. Obesity (Silver Spring). 2020 Dec;28(12):2339-2346. doi: 10.1002/oby.23015. Epub 2020 Oct 23.

  • Schumacher LM, Martinelli MK, Convertino AD, Forman EM, Butryn ML. Weight-Related Information Avoidance Prospectively Predicts Poorer Self-Monitoring and Engagement in a Behavioral Weight Loss Intervention. Ann Behav Med. 2021 Mar 16;55(2):103-111. doi: 10.1093/abm/kaaa034.

MeSH Terms

Conditions

ObesityOverweightWeight Loss

Condition Hierarchy (Ancestors)

OvernutritionNutrition DisordersNutritional and Metabolic DiseasesBody WeightSigns and SymptomsPathological Conditions, Signs and SymptomsBody Weight Changes

Limitations and Caveats

Low proportion of men and adults over age 70 limits generalizability; calls and texts were not qualitatively analyzed nor rated for treatment fidelity; length of each telephone session was not measured; it is unknown to what extent participants shared device data with friends/family/other participants and threatened contamination; low power.

Results Point of Contact

Title
Dr. Meghan Butryn
Organization
Drexel University

Study Officials

  • Meghan L Butryn, Ph.D.

    Drexel University

    PRINCIPAL INVESTIGATOR

Publication Agreements

PI is Sponsor Employee
No
Restrictive Agreement
No

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principle Investigator

Study Record Dates

First Submitted

November 7, 2017

First Posted

November 8, 2017

Study Start

November 17, 2017

Primary Completion

May 31, 2019

Study Completion

May 31, 2019

Last Updated

January 5, 2021

Results First Posted

January 5, 2021

Record last verified: 2020-12

Locations