Study of the Reaction of the Brain to Various Stimulations

NCT03334526 | Completed

• 1 other identifier: GREMEAUX 2017
• Study Type: interventional
• Target: 174
• Locations: 1 country
• Sites: 1

Brief Summary

Physical activity is considered a therapeutic strategy in its own right in a vast majority of disabling chronic disorders. It leads to an increase in physical and probably cognitive capacity, thanks to its effects on both metabolism (muscle hypertrophy, improvement in oxidative metabolism) and the nervous system (neuroplasticity). Nonetheless, even though there is a consensus on the positive effects of physical exercise (PE) on cerebral plasticity, the physiological mechanisms by which PE affects neuroplasticity, in particular depending on the mode of muscle contraction, are still hypothetical. Moreover, several recent studies have shown that mental learning (ML) by motor imagery improves motor performance, thus making it of interest in a context of rehabilitation, in particular in situations where PE is transient of definitively impossible. Yet, the mechanisms and brain structures involved in motor learning by ML have not been established so far. Finally, on the basis of clinical observations concerning the key role of sensory input in motor function, the hypothesis that increased demand on this input by electrical stimulation (ES) as a means to improve motor function has been proposed. However, the mechanisms by which this type of stimulation could induce neuroplasticity is still to be elucidated.

Conditions

Corticospinal Plasticity; Neuromuscular Plasticity

Outcome Measures

Primary Outcomes (1)

• level of corticospinal excitability

  through study completion, an average of 4 years

Study Arms (1)

healthy volunteers

EXPERIMENTAL

Other: physical training; Other: mental training; Other: electrical stimulation

Interventions

physical training OTHER

workout on treadmill requiring the muscles of the lower limbs mostly in concentric (ascent) or eccentric (downhill)

healthy volunteers

mental training OTHER

The task to imagine for the training group will be an abduction of the thumb

healthy volunteers

electrical stimulation OTHER

electrical stimulation of the muscles

healthy volunteers

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• persons who have provided written consent
• healthy subjects
• national health insurance cover
• age 18 to 60 years

You may not qualify if:

• personal or family history of epilepsy
• pacemakers or other apparatus likely to interfere with the magnetic field
• history of psychiatric disease
• Persons under guardianship or wards of court
• Pregnant or breast-feeding women
• problem perceived during the neurological examination which could bias the results of the study

Sponsors & Collaborators

• Centre Hospitalier Universitaire Dijon: lead

Study Sites (1)

CHU Dijon Bourgogne

Dijon, 21079, France

Location

Related Publications (1)

• Dupont W, Papaxanthis C, Lebon F, Madden-Lombardi C. Mental Simulations and Action Language Are Impaired in Individuals with Aphantasia. J Cogn Neurosci. 2024 Feb 1;36(2):261-271. doi: 10.1162/jocn_a_02084.

  PMID: 37944123 DERIVED

MeSH Terms

Interventions

Physical Conditioning, Human; Electric Stimulation

Intervention Hierarchy (Ancestors)

Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena; Physical Stimulation; Investigative Techniques

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: OTHER
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: this study is interventional because of it acts on the physical and respiratory capacities of patients

Study Record Dates

• First Submitted: October 13, 2017
• First Posted: November 7, 2017
• Study Start: November 9, 2017
• Primary Completion: June 24, 2022
• Study Completion: June 24, 2022
• Last Updated: February 16, 2023

Record last verified: 2023-02

Locations

FR (1)