Youth Experiences and Health Study

NCT03332966 | Recruiting

• 5 other identifiers: 684/6.02.01/2016207/13/03/00/16HUS/396/2017R16157314/2016
• Study Type: observational
• Target: 1,000
• Locations: 1 country
• Sites: 3

Brief Summary

This study aims to identify unusual experiences and psychiatric symptoms that indicate a heightened risk for severe mental disorders - especially psychoses. It is important to develop reliable questionnaire methods that are cost-effective in first-stage screening, leading to in-depth assessments and targeted care. However, existing psychosis-risk questionnaires are limited in content, intended for adults, and have been insufficiently tested for actual predictive value. Therefore we will collect a new, large dataset from an unselected group of adolescents entering psychiatric care in three major urban areas of Finland. Comprehensive national health care registers will be used to assess how well the selected experiences and symptoms predict the participants' mental health over the following few years.

Conditions

Psychotic Disorders; Psychiatric Hospitalization; Prodromal Symptoms; Cannabis Use; Trauma, Psychological

Keywords

adolescent; outpatients; questionnaire; psychotic-like symptoms; psychosis risk

Outcome Measures

Primary Outcomes (1)

• First psychosis disorder diagnosis

  National health care register diagnosis of non-organic psychosis

  5 years from recruitment (baseline questionnaire assessment)

Secondary Outcomes (2)

• Need for psychiatric care

  5 years from recruitment (baseline questionnaire assessment)

• Psychiatric hospitalization

  5 years from recruitment (baseline questionnaire assessment)

Study Arms (1)

Participants

The adolescent psychiatric organizations of the Helsinki University Central Hospital (serving the capital region's 1.1 million inhabitants), the Tampere University Hospital (catchment area of 500.000 inhabitants), and the Oulu University Hospital (catchment area of 500.000 inhabitants) have agreed to implement the data collection as part of routine intake assessments for patients aged 15-17. All consenting patients are enrolled; the only exclusion criterion is a previous diagnosis of psychotic disorder. The participants fill in psychiatric self-report questionnaires, and their structured diagnostic interview data are collected with their permission.

Diagnostic Test: Psychiatric questionnaires; Diagnostic Test: Semi-structured psychiatric interview

Interventions

Psychiatric questionnaires DIAGNOSTIC_TEST

Participants will fill in the following questionnaires as part of routine intake assessments: Generalised Anxiety Disorder Assessment (GAD-7); Mini-Social Phobia Inventory; Beck Depression Inventory 21A; Pittsburgh Sleep Quality Index; Insomnia Severity Index; Youth Experiences and Health Questionnaire; Adolescent Dissociative Experiences Scale (abbr.); Adolescent Peer Relations Instrument (APRI-B + cyberbullying, abbr.); Adolescent Trauma and Dissociation Scale (abbr.); Alcohol Use Disorders Identification Test; Alcohol, Smoking and Substance Involvement Screening Test - Lite (extended); Nicotine Questionnaire incl. Heavy Smoking Index; Internet Addiction Test (abbr.); European School Survey Project on Alcohol and Other Drugs 2015 Social Media Use and Computer Gaming; McMaster Family Assessment Device - General Functioning positive items; Multidimensional Scale of Perceived Social Support; Brief Resilience Scale; The Short Warwick-Edinburgh Mental Well-Being Scale

Participants

Semi-structured psychiatric interview DIAGNOSTIC_TEST

Kiddie Schedule for Affective Disorders and Schizophrenia, version K-SADS-PL 2013.

Participants

Eligibility Criteria

• Age: 15 Years - 18 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

All patients in the adolescent health clinics in three hospital districts of Finland.

You may qualify if:

• Start of care in adolescent mental health clinic

You may not qualify if:

• Previous diagnosis of psychotic disorder

Sponsors & Collaborators

• Finnish Institute for Health and Welfare: lead
• Hospital District of Helsinki and Uusimaa: collaborator
• Pirkanmaa Hospital District: collaborator
• Northern Ostrobothnia Hospital District: collaborator

Study Sites (3)

HUS Helsinki University Hospital, adolescent psychiatry clinics

Helsinki, 00029, Finland

NOT YET RECRUITING

Northern Ostrobothnia Hospital District, Adolescent Mental Health Clinic

Oulu, 90230, Finland

RECRUITING

Pirkanmaa Hospital District, Tays Central Hospital, Adolescent psychiatry clinic

Tampere, 33521, Finland

RECRUITING

Related Links

• Home page of the study (in Finnish)
• Finnish Institute for Health and Welfare institutional study catalog entry (in Finnish)

MeSH Terms

Conditions

Psychotic Disorders; Prodromal Symptoms; Psychological Trauma

Condition Hierarchy (Ancestors)

Schizophrenia Spectrum and Other Psychotic Disorders; Mental Disorders; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Stress Disorders, Traumatic; Trauma and Stressor Related Disorders

Study Officials

• Sebastian Therman, PhD

  Sebastian.Therman@THL.fi

  STUDY DIRECTOR

• Mauri Marttunen, MD, PhD

  Hospital District of Helsinki and Uusimaa

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Sebastian Therman, PhD

CONTACT

+358445405559; Sebastian.Therman@THL.fi

Jaana Suvisaari, MD, PhD

CONTACT

+358295248539; Jaana.Suvisaari@THL.fi

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 5 Years
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 1, 2017
• First Posted: November 6, 2017
• Study Start: December 1, 2019
• Primary Completion: December 31, 2024
• Study Completion: December 31, 2024
• Last Updated: September 25, 2024

Record last verified: 2024-09

Locations

FI (3)