Trials Sponsors Conditions Drugs Pricing

Conditions

Cessation, Tobacco Cigarette Smoking Smoking Cessation Smoking, Tobacco Smoking (Tobacco) Addiction

Keywords

BupropionSmokersSmoking cessationCigarette smokingCigarette

Outcome Measures

Primary Outcomes (1)

Point Prevalence Abstinence (PPA) [change in abstinence reports will be assessed]
Self report of smoking status
Through study completion, an average of 26 months

Secondary Outcomes (8)

Smoking cessation milestones
Through study completion, an average of 26 months
Inventory of Depressive and Anxious Symptomology (General depression subscale)
Through study completion, an average of 26 months

Study Arms (2)

BUP-300

ACTIVE COMPARATOR

Participants will receive Bupropion hydrochloride for 10 weeks and titrate to a maximum dose of 300 mg/day and will also receive standard smoking cessation counseling for 8 weeks.

Drug: Bupropion Hydrochloride

BUP-450

EXPERIMENTAL

Participants will receive Bupropion hydrochloride for 12 weeks and titrate to a maximum dose of 450 mg/day and will also receive standard smoking cessation counseling for 8 weeks.

Drug: Bupropion Hydrochloride

Interventions

Bupropion HydrochlorideDrug

Antidepressant that is also effective in smoking cessation

Also known as: Bupropion

BUP-300BUP-450

Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.

Eligibility Criteria

Age21 Years - 65 Years

Sexall

Healthy VolunteersYes

Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

Smokes cigarettes daily for at least 1 year
Breath CO of 5 ppm or higher at Baseline visit

Sponsors & Collaborators

University of Southern California
Otherlead
University of California, San Diego
Othercollaborator
University of California, Los Angeles

Study Sites (1)

University of Southern California

Los Angeles, California, 90033, United States

Related Publications (12)

Leventhal AM, Kahler CW, Ray LA, Zimmerman M. Refining the depression-nicotine dependence link: patterns of depressive symptoms in psychiatric outpatients with current, past, and no history of nicotine dependence. Addict Behav. 2009 Mar;34(3):297-303. doi: 10.1016/j.addbeh.2008.11.008. Epub 2008 Nov 21.
PMID: 19062199BACKGROUND
Brown RA, Niaura R, Lloyd-Richardson EE, Strong DR, Kahler CW, Abrantes AM, Abrams D, Miller IW. Bupropion and cognitive-behavioral treatment for depression in smoking cessation. Nicotine Tob Res. 2007 Jul;9(7):721-30. doi: 10.1080/14622200701416955.
PMID: 17577801BACKGROUND

MeSH Terms

Conditions

Smoking CessationTobacco SmokingSmokingBehavior, AddictiveTobacco Use CessationCigarette Smoking

Interventions

Bupropion

Condition Hierarchy (Ancestors)

Health BehaviorBehaviorTobacco UseCompulsive BehaviorImpulsive Behavior

Intervention Hierarchy (Ancestors)

Propiophenones

Study Officials

Adam M Leventhal, PhD
University of Southern California
PRINCIPAL INVESTIGATOR

Enrollment

12 participants (actual enrollment reported by the registry).

Study Design

Study Type: interventional
Phase: phase 2
Allocation: RANDOMIZED
Masking: SINGLE
Who Masked: PARTICIPANT
Masking Details: Participants will be unaware of which medication condition they have been assigned to; however, the study team and the care provider will know which dose of medication they are distributing.
Purpose: TREATMENT
Intervention Model: PARALLEL
Sponsor Type: OTHER
Responsible Party: PRINCIPAL INVESTIGATOR
PI Title: Associate Professor

Study Record Dates

First Submitted

October 18, 2017

First Posted

October 31, 2017

Study Stopped

High Dose Bupropion for Smoking Cessation - Pilot Study

Brief Summary

Registry Overview

Trial Relationships

Study Timeline

First Submitted

First Posted

Study Start

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (8)

Study Arms (2)

BUP-300

BUP-450

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

Related Publications (12)

MeSH Terms

Conditions

Interventions

Condition Hierarchy (Ancestors)

Intervention Hierarchy (Ancestors)

Study Officials

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Data Sharing

Source record

Documents

Locations

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

First Submitted

First Posted

Study Start

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (8)

Study Arms (2)

BUP-300

BUP-450

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

Related Publications (12)

MeSH Terms

Conditions

Interventions

Condition Hierarchy (Ancestors)

Intervention Hierarchy (Ancestors)

Study Officials

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Data Sharing

Source record

Documents

Locations