NCT03296007

Brief Summary

The aim of the present study is to evaluate the psychophysiological effects of a smart phone based mindfulness meditation app (MMA) for individuals with clinically significant symptoms of major depression and/or anxiety, or symptoms of chronic pain. Specifically, the study aims to examine parasympathetic tone using HRV (primary outcome), mind-wandering and present awareness, mood symptoms, and breath focus in groups of participants who self-report clinically significant symptoms of depression and/or anxiety (DA), chronic pain symptoms (CP), as well as control participants who do not meet our criteria for either (Controls (C). All study groups will be randomized to a mindfulness meditation app (MMA+) condition or a mindfulness meditation condition without the app (MMA-) after a brief stress-induction procedure.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
2,016

participants targeted

Target at P75+ for not_applicable chronic-pain

Timeline
Completed

Started Nov 2017

Typical duration for not_applicable chronic-pain

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

September 22, 2017

Completed
6 days until next milestone

First Posted

Study publicly available on registry

September 28, 2017

Completed
1 month until next milestone

Study Start

First participant enrolled

November 10, 2017

Completed
2.5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 1, 2020

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

May 1, 2020

Completed
Last Updated

June 9, 2022

Status Verified

June 1, 2022

Enrollment Period

2.5 years

First QC Date

September 22, 2017

Last Update Submit

June 7, 2022

Conditions

Outcome Measures

Primary Outcomes (1)

  • Heart Rate Variability

    A stress biomarker derived from heart rate recordings that reflects parasympathetic control of cardiac output

    22 minutes

Study Arms (2)

Mindfulness Meditation App

EXPERIMENTAL

Participants randomized to this arm will use a smartphone app to practice mindfulness meditation for 12 minutes.

Behavioral: Mindfulness Meditation

Mindfulness Meditation No App

ACTIVE COMPARATOR

Participants randomized to this arm will not use a smartphone app, but will receive instructions to practice mindfulness meditation for 12 minutes.

Behavioral: Mindfulness Meditation

Interventions

A meditative practice involving paying attention to present moment experiences and focusing on breathing sensations.

Mindfulness Meditation AppMindfulness Meditation No App

Eligibility Criteria

Age18 Years - 65 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • York University students

You may not qualify if:

  • Individuals with diagnosed cardiac conditions (e.g. coronary artery disease, arrhythmias etc) will be excluded due to confounds with heart rate variability assessment

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

York University

Toronto, Ontario, M3J 1P3, Canada

Location

Related Publications (1)

  • Azam MA, Latman VV, Katz J. Effects of a 12-Minute Smartphone-Based Mindful Breathing Task on Heart Rate Variability for Students With Clinically Relevant Chronic Pain, Depression, and Anxiety: Protocol for a Randomized Controlled Trial. JMIR Res Protoc. 2019 Dec 2;8(12):e14119. doi: 10.2196/14119.

MeSH Terms

Conditions

Chronic PainDepressionAnxiety Disorders

Interventions

Mindfulness

Condition Hierarchy (Ancestors)

PainNeurologic ManifestationsSigns and SymptomsPathological Conditions, Signs and SymptomsBehavioral SymptomsBehaviorMental Disorders

Intervention Hierarchy (Ancestors)

Cognitive Behavioral TherapyBehavior TherapyPsychotherapyBehavioral Disciplines and Activities

Study Officials

  • Joel Katz, PhD

    York University

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor

Study Record Dates

First Submitted

September 22, 2017

First Posted

September 28, 2017

Study Start

November 10, 2017

Primary Completion

May 1, 2020

Study Completion

May 1, 2020

Last Updated

June 9, 2022

Record last verified: 2022-06

Data Sharing

IPD Sharing
Will not share

Locations