NCT03534856

Brief Summary

Roughly 30% of stroke survivors experience spasticity, a velocity-dependent increase in stretch reflexes. In this pilot study, the investigators aimed to examine the effects of mindfulness meditation on spasticity and quality of life in individuals after stroke.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
11

participants targeted

Target at below P25 for not_applicable stroke

Timeline
Completed

Started Jul 2016

Shorter than P25 for not_applicable stroke

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

July 13, 2016

Completed
7 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

February 17, 2017

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

February 17, 2017

Completed
1.2 years until next milestone

First Submitted

Initial submission to the registry

April 17, 2018

Completed
1 month until next milestone

First Posted

Study publicly available on registry

May 23, 2018

Completed
Last Updated

February 22, 2024

Status Verified

February 1, 2024

Enrollment Period

7 months

First QC Date

April 17, 2018

Last Update Submit

February 20, 2024

Conditions

Outcome Measures

Primary Outcomes (1)

  • Change from Baseline Modified Ashworth Scale at 2 weeks

    This scale measures post-stroke spasticity on a scale that ranges from 0-4 where 0 is no spasticity and the higher value represents a greater spasticity

    This was measured before and after two weeks of meditation

Secondary Outcomes (4)

  • Change from Baseline Fugl Meyer Upper Extremity Scale at 2 weeks

    This was measured before and after two weeks of meditation

  • Change from Baseline Stroke Specific Quality of Life Survey at 2 weeks

    This was measured before and after two weeks of meditation

  • Change from Baseline Freiburg Mindfulness Inventory at 2 weeks

    This was measured before and after two weeks of meditation

  • Change from Baseline Hospital Anxiety and Depression Scale at 2 weeks

    This was measured before and after two weeks of meditation

Study Arms (1)

Mindfulness meditation

EXPERIMENTAL

Two weeks of short, daily guided mindfulness meditations were provided.

Behavioral: Mindfulness meditation

Interventions

Short guided mindfulness meditations were provided on an MP3 player.

Mindfulness meditation

Eligibility Criteria

Age18 Years - 99 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Chronic stroke (greater than 1 year post stroke)
  • Over 18 years old
  • Moderate to severe motor deficits with self-reported spasticity
  • No prior mindfulness meditation experience

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University of Southern California

Los Angeles, California, 90089, United States

Location

Related Publications (1)

  • Wathugala M, Saldana D, Juliano JM, Chan J, Liew SL. Mindfulness Meditation Effects on Poststroke Spasticity: A Feasibility Study. J Evid Based Integr Med. 2019 Jan-Dec;24:2515690X19855941. doi: 10.1177/2515690X19855941.

MeSH Terms

Conditions

StrokeMuscle Spasticity

Interventions

Mindfulness

Condition Hierarchy (Ancestors)

Cerebrovascular DisordersBrain DiseasesCentral Nervous System DiseasesNervous System DiseasesVascular DiseasesCardiovascular DiseasesMuscular DiseasesMusculoskeletal DiseasesMuscle HypertoniaNeuromuscular ManifestationsNeurologic ManifestationsSigns and SymptomsPathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Cognitive Behavioral TherapyBehavior TherapyPsychotherapyBehavioral Disciplines and Activities

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
TREATMENT
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Assistant Professor

Study Record Dates

First Submitted

April 17, 2018

First Posted

May 23, 2018

Study Start

July 13, 2016

Primary Completion

February 17, 2017

Study Completion

February 17, 2017

Last Updated

February 22, 2024

Record last verified: 2024-02

Data Sharing

IPD Sharing
Will not share

Locations