Evolution of the Profile of Infectious Endocarditis in France in 2008 (EI2008)

NCT03295045 | Completed

• 1 other identifier: N/2007/50
• Study Type: observational
• Target: 484
• Locations: 0 countries
• Sites: N/A

Brief Summary

Infective endocarditis (IE) is a rare (30 cases / million / year in France) and serious (20 % of deaths during hospitalization) disease . Its epidemiological profile was considerably modified these last years.New predisposing factors appeared, due to increasing number of patients wearing valvular prosthetics. The purpose of this study is to realize in 2008 a new observational study on populational basis to describe and analyze the evolution of the epidemiology of IE in France, compared to previous studies conducted in 1991 and 1999.

Conditions

Infective Endocarditis

Outcome Measures

Primary Outcomes (1)

• Mortality

  Vital status

  1 year

Secondary Outcomes (1)

• Frequency of antibiotic resistance by the germs (streptococci and staphylococci)

  during the hospitalization, 1 year maximum

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Inpatients with infective endocarditis living in one of the studied regions

You may qualify if:

• Major Patient
• Supported in one of the participating centers
• The application of diagnostic classification criteria of Duke modified by Li is carried out after collection of all the data at the output of the patient. Will be included in the observatory that patients meeting criteria for definite or possible endocarditis.
• Affiliated with the French social security regime

You may not qualify if:

• Patients not living in one of the studied regions

Sponsors & Collaborators

• Centre Hospitalier Universitaire de Besancon: lead
• Bichat Hospital: collaborator
• Hopital Louis Pradel: collaborator
• Central Hospital, Nancy, France: collaborator
• University Hospital, Montpellier: collaborator
• CHU de Reims: collaborator
• Rennes University Hospital: collaborator
• Hotel Dieu Hospital: collaborator
• Henri Mondor University Hospital: collaborator

Related Publications (2)

• Selton-Suty C, Celard M, Le Moing V, Doco-Lecompte T, Chirouze C, Iung B, Strady C, Revest M, Vandenesch F, Bouvet A, Delahaye F, Alla F, Duval X, Hoen B; AEPEI Study Group. Preeminence of Staphylococcus aureus in infective endocarditis: a 1-year population-based survey. Clin Infect Dis. 2012 May;54(9):1230-9. doi: 10.1093/cid/cis199.

  PMID: 22492317 RESULT

• Duval X, Delahaye F, Alla F, Tattevin P, Obadia JF, Le Moing V, Doco-Lecompte T, Celard M, Poyart C, Strady C, Chirouze C, Bes M, Cambau E, Iung B, Selton-Suty C, Hoen B; AEPEI Study Group. Temporal trends in infective endocarditis in the context of prophylaxis guideline modifications: three successive population-based surveys. J Am Coll Cardiol. 2012 May 29;59(22):1968-76. doi: 10.1016/j.jacc.2012.02.029.

  PMID: 22624837 RESULT

MeSH Terms

Conditions

Endocarditis

Condition Hierarchy (Ancestors)

Heart Diseases; Cardiovascular Diseases

Study Officials

• Bruno HOEN, MD PhD

  Centre Hospitalier Universitaire de Pointe à Pitre

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 5, 2017
• First Posted: September 27, 2017
• Study Start: December 1, 2007
• Primary Completion: December 31, 2009
• Study Completion: December 31, 2010
• Last Updated: September 27, 2017

Record last verified: 2017-09

Data Sharing

• IPD Sharing: Will not share