CUHK Stroke Biobank

NCT03291392 | Recruiting

• 1 other identifier: crec no. 2014.582
• Study Type: observational
• Target: 500
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of the study are:

1. 1.To make quality, characterized samples and related data available for future studies, including Genome Wide Association Studies (GWAS), genomics, and biomarker research;
2. 2.To use these samples and related medical information to answer research questions aimed at understanding the genetics and underlying biology of acquired disease and injury to the brain, heart and blood vessels with the express purpose of advancing the search for effective modalities for prevention, treatment, and recovery;
3. 3.To develop additional operational infrastructure to support this project across the Prince of Wales Hospital and divisions, including (1) tracking of patient consent, (2) management of collection and sample processing processes, (3) sample inventory and QC/QA processes, and (4) release of materials to investigators for further research.

Conditions

Stroke, Ischemic; Genetic Disease; Atherosclerosis, Cerebral

Keywords

Genetics; Stroke; Biobank; Atherosclerosis

Outcome Measures

Primary Outcomes (1)

• Ischemic stroke-related genetics

  1. Discovery of novel genetic predictor of stroke and its complications will be done by identifying cases and controls for different stroke subtype and complications within the recruited samples, and using whole-genome genotyping arrays, or by sequencing approaches. 2. Replication of novel genetic markers of stroke will be performed using a combination of genotyping, multiplex genotyping, customized-content genotyping arrays and sequencing.

  Dec, 2025

Study Arms (3)

Atherosclerosis

Patient with intracranial stenosis or extracranial stenosis equal to or more than 70% would be invited to join the study for blood taking. Biobank: Gene expression or biomarkers exploration for atherosclerotic-related genetic diseases

Genetic: Gene expression or biomarkers exploration

Family members

The stroke patient who had family history of stroke, their parents and siblings would also be invited to join the study for blood taking or buccal swab/ saliva collection. Biobank: Gene expression or biomarkers exploration for atherosclerotic-related genetic diseases

Genetic: Gene expression or biomarkers exploration

Normal subjects

Normal subjects without ischemic stroke or intracranial/extracranial stenosis would be invited to join the study for blood taking. Biobank: Gene expression or biomarkers exploration for atherosclerotic-related genetic diseases

Genetic: Gene expression or biomarkers exploration

Interventions

Gene expression or biomarkers exploration GENETIC

Atherosclerosis; Family members; Normal subjects

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

1. Chinese ONLY 2. Patients with intracranial stenosis or extracranial stenosis equal to or \>70% 3. Stroke patients and their family members 4. Normal subject without any intracranial stenosis/ extracranial stenosis

You may qualify if:

• Adult equal or more 18 years of age and Chinese ONLY.
• Stroke patients, their family members, and/or the normal subjects without intracranial stenosis or extracranial stenosis, are eligible to join the study.
• Subject is willing to have blood taken, cerebral spinal fluid and/or body tissue drawn for storage in the research bank.

You may not qualify if:

• None

Sponsors & Collaborators

• Chinese University of Hong Kong: lead

Study Sites (1)

Chinese University of Hong Kong

Hong Kong, Hong Kong

RECRUITING

Biospecimen

Retention: SAMPLES WITH DNA

30ml of EDTA blood, buccal swab or saliva, body tissue, or cerebrospinal fluid to be collected

MeSH Terms

Conditions

Ischemic Stroke; Genetic Diseases, Inborn; Intracranial Arteriosclerosis; Stroke; Atherosclerosis

Interventions

Gene Expression

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Intracranial Arterial Diseases; Arteriosclerosis; Arterial Occlusive Diseases

Intervention Hierarchy (Ancestors)

Genetic Phenomena

Study Officials

• Thomas Wai Hong LEUNG, FRCP

  Chinese University of Hong Kong

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Thomas Wai Hong LEUNG, FRCP

CONTACT

852-35053593; drtleung@cuhk.edu.hk

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: OTHER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: September 19, 2017
• First Posted: September 25, 2017
• Study Start: June 15, 2015
• Primary Completion (Estimated): December 31, 2026
• Study Completion (Estimated): December 31, 2027
• Last Updated: February 24, 2026

Record last verified: 2026-02

Locations

HK (1)