Doppler Ultrasound in Early Detection of Diabetic Nephropathy Type 2 Diabetes Mellitus.

NCT03284996 | Unknown

• 1 other identifier: DUDN
• Study Type: observational
• Target: 80
• Locations: 0 countries
• Sites: N/A

Brief Summary

Doppler sonography provides an easily applicable, non-invasive, and well-established method for investigating renal morphologic characteristics and measuring vascular resistance in the renal parenchyma. Doppler are of strategic importance in providing qualitative and quantitative information about the renal vasculature, which can be obtained through the assessment of the resistive index.

Conditions

Diabetic Nephropathies

Outcome Measures

Primary Outcomes (1)

• Early detection of diabetic nephropathy in patients with type 2 diabetes mellitus by measuring changes in renal resistive index using Doppler ultrasonography

  Early detection of diabetic nephropathy in patients with type 2 diabetes mellitus by measuring changes in renal resistive index using Doppler ultrasonography

  2 years

Interventions

Doppler ultrasonography DEVICE

Examination of the whole cases \& controls by doppler ultrasound to measure renal resistive index.

Eligibility Criteria

• Age: 25 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

The study was designed as a single-center case control study in which we'll evaluate intra-renal hemodynamic changes with Doppler sonography in diabetic patients in comparison to non-diabetic controls, by studying 80 cases, 40 cases of patients with type 2 diabetes mellitus from the diabetes \& nephrology outpatient clinic in Assiut University Hospital (group A) and 40 age-matched healthy adults served as a control group (group B).

You may qualify if:

• \. Type 2 diabetic patients. 2. Serum creatinine \<1.2 mg/dl

You may not qualify if:

• \- 1. patients with known history of renal disease or any systemic diseases with renal complications.
• \. Serum creatinine \>1.2 mg/dl

Sponsors & Collaborators

• Assiut University: lead

Related Publications (4)

• Nelson TR, Pretorius DH. The Doppler signal: where does it come from and what does it mean? AJR Am J Roentgenol. 1988 Sep;151(3):439-47. doi: 10.2214/ajr.151.3.439.

  PMID: 2970215 RESULT

• Tublin ME, Bude RO, Platt JF. Review. The resistive index in renal Doppler sonography: where do we stand? AJR Am J Roentgenol. 2003 Apr;180(4):885-92. doi: 10.2214/ajr.180.4.1800885. No abstract available.

  PMID: 12646425 RESULT

• Tang SC, Chan GC, Lai KN. Recent advances in managing and understanding diabetic nephropathy. F1000Res. 2016 May 31;5:F1000 Faculty Rev-1044. doi: 10.12688/f1000research.7693.1. eCollection 2016.

  PMID: 27303648 RESULT

• Mancini M, Masulli M, Liuzzi R, Mainenti PP, Ragucci M, Maurea S, Riccardi G, Vaccaro O. Renal duplex sonographic evaluation of type 2 diabetic patients. J Ultrasound Med. 2013 Jun;32(6):1033-40. doi: 10.7863/ultra.32.6.1033.

  PMID: 23716525 RESULT

MeSH Terms

Conditions

Diabetic Nephropathies

Interventions

Ultrasonography, Doppler

Condition Hierarchy (Ancestors)

Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Diabetes Complications; Diabetes Mellitus; Endocrine System Diseases

Intervention Hierarchy (Ancestors)

Ultrasonography; Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis

Central Study Contacts

Hassan Ibrahim Megally, Professor

CONTACT

00201006209845; hasanibrahim48@aun.edu.eg

Abolhassan Hasseeb Mohamed, Lecturer

CONTACT

00201009562059; abolhasan_96@aun.edu.eg

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal investigator

Study Record Dates

• First Submitted: September 14, 2017
• First Posted: September 15, 2017
• Study Start: October 1, 2017
• Primary Completion: April 30, 2019
• Study Completion: September 1, 2019
• Last Updated: September 15, 2017

Record last verified: 2017-09