Determinants of Adolescent, Now Young Adults, Social Well-being and Health: Longitudinal Follow-up

NCT03283332 | Completed

• 1 other identifier: 05/MRE10/43
• Study Type: observational
• Target: 6,643
• Locations: 0 countries
• Sites: N/A

Brief Summary

Black and ethnic minority groups living in the UK experience high rates of chronic diseases such as diabetes, hypertension and heart disease, general morbidity and poor mental health. The cause of these excess rates is unknown but obesity, smoking, diet and deprivation are important contributing factors. There is also global evidence of the association of these diseases in adulthood with health and deprivation in early life and childhood. Persisting social deprivation over the lifecourse is disproportionately borne by some ethnic minorities (Harding and Balarajan 2001) but the impact on the health of their children is virtually unknown. Least is known about the health of Black Caribbean young people. It is important to examine risk factor differences by social predictors within the ethnic minority groups as well as between them. The DASH Study started as a school-based cohort study of adolescents from the main ethnic groups (White British, Black Caribbean, Black African, Indian, Pakistani and Bangladeshi) in 10 London boroughs. Wave 1 took place in 2002/03 (MREC Ref: MREC/2/10/12), when participants were aged 11-13 years (school years 7 and 8). Wave 2 took place in 2005/06 (MREC Ref: 05/MRE10/43) when they were 14-16 years (school years 9 and 10). Wave 3 took place in 2010/2011, when participants were aged 19-21 years and involved a postal follow-up complemented by telephone interview and on-line questionnaires. The current proposal is for a feasibility study, using a small sample of the DASH cohort, to inform the design of the next full face-to-face follow-up. DASH will be the first large scale UK longitudinal cohort of ethnic minority youths with both social and biological measures from childhood to early adulthood. It will allow detailed examination of ethnic differences in the social patterning of biological mechanisms and pre-clinical disease in young adulthood.

Conditions

Cardiovascular Risk Factor

Keywords

Ethnicity; adolescents; cohort; longitudinal; health inequalities

Outcome Measures

Primary Outcomes (3)

• Response rate

  Percentage response rates - overall, per item/physical measure

  Through study completion, on average 10 years

• Interview duration

  Mean length of time for interview

  Through study completion, on average 10 years

• physical measures duration

  Mean length of time for physical/biological measures

  Through study completion, on average 10 years

Secondary Outcomes (19)

• Weight

  Through study completion, on average 10 years

• Height

  Through study completion, on average 10 years

• waist circumference

  Through study completion, on average 10 years

• blood pressure

  Through study completion, on average 10 years

• Body fat

  Through study completion, on average 10 years

Interventions

No intervention OTHER

Eligibility Criteria

• Age: 11 Years - 13 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)
• Sampling Method: Probability Sample

Study Population

School children, aged 11-13 years, representing the main UK ethnic groups (White-European, Black African, Black Caribbean, Indian, Pakistani/Bangladeshi, Other, mainly mixed race).

You may qualify if:

• provision of informed consent

You may not qualify if:

• none

Sponsors & Collaborators

• King's College London: lead
• Medical Research Council: collaborator
• Chief Scientist Office of the Scottish Government: collaborator

Related Publications (10)

• Harding S, Whitrow M, Maynard MJ, Teyhan A. Cohort profile: The DASH (Determinants of Adolescent Social well-being and Health) Study, an ethnically diverse cohort. Int J Epidemiol. 2007 Jun;36(3):512-7. doi: 10.1093/ije/dym094. Epub 2007 Jul 30. No abstract available.

  PMID: 17664225 RESULT

• Lu Y, Sooky L, Silva MJ, Molaodi OR, Karamanos A, Cruickshank JK, Harding S. Longitudinal study of the influence of lung function on vascular health from adolescence to early adulthood in a British multiethnic cohort. J Hypertens. 2017 Nov;35(11):2185-2191. doi: 10.1097/HJH.0000000000001455.

  PMID: 28661960 RESULT

• Harding S, Silva MJ, Molaodi OR, Enayat ZE, Cassidy A, Karamanos A, Read UM, Cruickshank JK. Longitudinal study of cardiometabolic risk from early adolescence to early adulthood in an ethnically diverse cohort. BMJ Open. 2016 Dec 14;6(12):e013221. doi: 10.1136/bmjopen-2016-013221.

  PMID: 27979836 RESULT

• Faconti L, Silva MJ, Molaodi OR, Enayat ZE, Cassidy A, Karamanos A, Nanino E, Read UM, Dall P, Stansfield B, Harding S, Cruickshank KJ. Can arterial wave augmentation in young adults help account for variability of cardiovascular risk in different British ethnic groups? J Hypertens. 2016 Nov;34(11):2220-6. doi: 10.1097/HJH.0000000000001066.

  PMID: 27490950 RESULT

• Harding S, Read UM, Molaodi OR, Cassidy A, Maynard MJ, Lenguerrand E, Astell-Burt T, Teyhan A, Whitrow M, Enayat ZE. The Determinants of young Adult Social well-being and Health (DASH) study: diversity, psychosocial determinants and health. Soc Psychiatry Psychiatr Epidemiol. 2015 Aug;50(8):1173-88. doi: 10.1007/s00127-015-1047-9. Epub 2015 Apr 11.

  PMID: 25861790 RESULT

• Whitrow MJ, Harding S. Asthma in Black African, Black Caribbean and South Asian adolescents in the MRC DASH study: a cross sectional analysis. BMC Pediatr. 2010 Mar 25;10:18. doi: 10.1186/1471-2431-10-18.

  PMID: 20334698 RESULT

• Harding S, Teyhan A, Maynard MJ, Cruickshank JK. Ethnic differences in overweight and obesity in early adolescence in the MRC DASH study: the role of adolescent and parental lifestyle. Int J Epidemiol. 2008 Feb;37(1):162-72. doi: 10.1093/ije/dym252. Epub 2008 Jan 19.

  PMID: 18204089 RESULT

• Maynard MJ, Harding S, Minnis H. Psychological well-being in Black Caribbean, Black African, and White adolescents in the UK Medical Research Council DASH study. Soc Psychiatry Psychiatr Epidemiol. 2007 Sep;42(9):759-69. doi: 10.1007/s00127-007-0227-7. Epub 2007 Jun 29.

  PMID: 17603738 RESULT

• Harding S, Maynard MJ, Cruickshank K, Teyhan A. Overweight, obesity and high blood pressure in an ethnically diverse sample of adolescents in Britain: the Medical Research Council DASH study. Int J Obes (Lond). 2008 Jan;32(1):82-90. doi: 10.1038/sj.ijo.0803662. Epub 2007 Jun 19.

  PMID: 17579635 RESULT

• Harding S, Maynard M, Cruickshank JK, Gray L. Anthropometry and blood pressure differences in black Caribbean, African, South Asian and white adolescents: the MRC DASH study. J Hypertens. 2006 Aug;24(8):1507-14. doi: 10.1097/01.hjh.0000239285.20315.4d.

  PMID: 16877952 RESULT

Study Officials

• Seeromanie Harding, PhD

  King's College London

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 8, 2017
• First Posted: September 14, 2017
• Study Start: December 1, 2011
• Primary Completion: December 1, 2012
• Study Completion: December 1, 2012
• Last Updated: September 14, 2017

Record last verified: 2017-09

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, ICF
• Time Frame: Data available from 2014 for 10 years.