NCT02368938

Brief Summary

The Northern Shanghai Study is a prospective community-based study, which is aimed to investigate the prognostic factors, including conventional cardiovascular risk factors and asymptomatic target organ damage, for mortality and cardiovascular diseases, in 5,000 elderly Chinese.

Trial Health

50
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
5,000

participants targeted

Target at P75+ for all trials

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

August 1, 2014

Completed
7 months until next milestone

First Submitted

Initial submission to the registry

February 15, 2015

Completed
8 days until next milestone

First Posted

Study publicly available on registry

February 23, 2015

Completed
2.5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 1, 2017

Completed
Last Updated

February 23, 2015

Status Verified

February 1, 2015

Enrollment Period

3.1 years

First QC Date

February 15, 2015

Last Update Submit

February 20, 2015

Conditions

Cardiovascular Risk Factor

Keywords

Cardiovascular risk factorsProspective studyMortalityCardiovascular eventsAsymptomatic target organ damageelderly Chinese

Outcome Measures

Primary Outcomes (2)

  • all-cause and cardiovascular mortality, cardiovascular events

    one year

  • Cardiovascular diseases

    one year

Study Arms (1)

Several communities in the north of Shanghai

Eligibility Criteria

Age65 Years+
Sexall
Healthy VolunteersYes
Age GroupsOlder Adult (65+)
Sampling MethodProbability Sample
Study Population

5000 subjects aged over 65 years old, living in communities located in the northern Shanghai, will be invited to participate in the present study, if they are willing to give their written informed consents.

You may qualify if:

  • age≥65 years old(depending on identity card);
  • informed consent should be signed voluntarily;
  • the individuals are long-term residents in northern Shanghai.

You may not qualify if:

  • is diagnosed serious heart disease (NYHA\>IV) or end stage renal disease (CKD \> 4);
  • suffered with cancer and life expectancy was less than 5 years;
  • has stroke within 3 months;
  • is not willing to participate in the clinical study;
  • suffered with other disease to quite the trial;
  • violated the protocol;
  • lost contact with laboratory staff.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Related Publications (15)

  • Han J, Tang J, Zhao Y, Xiong J, Zhao S, Yue W, Xu Y, Yu S, Zhang Y; Northern Shanghai Study. Subendocardial Viability Ratio Is Associated With Target Organ Damage and Hints at a Potential Independent Predictor of Cardiovascular Mortality in Older Adults: A Prospective Cohort Study. J Am Heart Assoc. 2026 Jan 6;15(1):e043643. doi: 10.1161/JAHA.125.043643. Epub 2025 Dec 30.

    PMID: 41467407DERIVED

  • Xu C, Zhao S, Tang J, Han J, Zhang H, Liu W, Zhao Y, Xu Y, Zhang Y. Associations between different anthropometric measures and major adverse cardiovascular events among the elderly in China. Obes Res Clin Pract. 2025 Nov-Dec;19(6):497-502. doi: 10.1016/j.orcp.2025.10.010. Epub 2025 Nov 9.

    PMID: 41207843DERIVED

  • Shi J, Ye X, Yu S, Zhao Y, Xiong J, Ji H, Zhang Y. Vascular Aging, Cardiovascular-Kidney-Metabolic Syndrome, and Cardiovascular Risk: The Northern Shanghai Study. JACC Adv. 2025 Oct 16;4(12):102242. doi: 10.1016/j.jacadv.2025.102242. Online ahead of print.

    PMID: 41165644DERIVED

  • Ren Z, Yang H, Zhu W, Han J, Yu S, Zhao S, Meng W, Xu Y, Zhao Y, Zhang Y. Age and blood pressure stratified healthy vascular aging, organ damage and prognosis in the community-dwelling elderly: insights from the North Shanghai Study. Clin Hypertens. 2024 Nov 1;30(1):31. doi: 10.1186/s40885-024-00288-3.

    PMID: 39482774DERIVED

  • Zhao S, Tang J, Yu S, Maimaitiaili R, Teliewubai J, Xu C, Li J, Chi C, Xu Y, Zhang Y. Monocyte to high-density lipoprotein ratio presents a linear association with atherosclerosis and nonlinear association with arteriosclerosis in elderly Chinese population: The Northern Shanghai Study. Nutr Metab Cardiovasc Dis. 2023 Mar;33(3):577-583. doi: 10.1016/j.numecd.2022.12.002. Epub 2022 Dec 10.

    PMID: 36646605DERIVED

  • Lyu Y, Yu S, Chi C, Teliewubai J, Li J, Blacher J, Pu J, Zhang Y, Xu Y. Associations of Walking Activity With Hypertensive Mediated Organ Damage in Community-Dwelling Elderly Chinese: The Northern Shanghai Study. Front Cardiovasc Med. 2021 Oct 21;8:734766. doi: 10.3389/fcvm.2021.734766. eCollection 2021.

    PMID: 34746252DERIVED

  • Ren Z, Zhang J, Yu S, Zhao S, Tang J, Zheng Y, Meng W, Xu C, Zhang Y, Xu Y. Hypertension-Mediated Organ Damage Correlates With Serum Homocysteine Level in Community-Dwelling Elderly Chinese: The North Shanghai Study. Front Cardiovasc Med. 2021 May 10;8:662741. doi: 10.3389/fcvm.2021.662741. eCollection 2021.

    PMID: 34041284DERIVED

  • Xu C, Zhao S, Yu S, Chi C, Fan X, Ji H, Maimaitiaili R, Teliewubai J, Li X, Zhang Y, Xu Y. Association between organ damage and visceral adiposity index in community-dwelling elderly Chinese population: the Northern Shanghai Study. Aging Clin Exp Res. 2021 Aug;33(8):2291-2297. doi: 10.1007/s40520-020-01752-4. Epub 2020 Nov 21.

    PMID: 33219935DERIVED

  • Teliewubai J, Fan X, Ji H, Maimaitiaili R, Tang J, Zhao S, Yu S, Chi C, Xu Y, Zhang Y. Does healthy obesity exist in the elderly? Findings from the Northern Shanghai Study. Nutr Metab Cardiovasc Dis. 2020 May 7;30(5):749-757. doi: 10.1016/j.numecd.2020.01.010. Epub 2020 Jan 25.

    PMID: 32249139DERIVED

  • Fan X, Teliewubai J, Xiong J, Chi C, Lu Y, Zhu M, Zhang Y, Xu Y. Renal functional impairment in the elderly, the importance of fasting plasma glucose: the Northern Shanghai Study. Aging Clin Exp Res. 2021 Feb;33(2):353-360. doi: 10.1007/s40520-020-01527-x. Epub 2020 Mar 21.

    PMID: 32200498DERIVED

  • Chi C, Teliewubai J, Lu YY, Fan XM, Yu SK, Xiong J, Zhou YW, Ji HW, Zhang Y, Xu YW. Comparison of various lipid parameters in association of target organ damage: a cohort study. Lipids Health Dis. 2018 Aug 25;17(1):199. doi: 10.1186/s12944-018-0800-y.

    PMID: 30144803DERIVED

  • Teliewubai J, Bai B, Zhou Y, Lu Y, Yu S, Chi C, Li J, Blacher J, Xu Y, Zhang Y. Association of asymptomatic target organ damage with secreted frizzled related protein 5 in the elderly: the Northern Shanghai Study. Clin Interv Aging. 2018 Mar 6;13:389-395. doi: 10.2147/CIA.S155514. eCollection 2018.

    PMID: 29551893DERIVED

  • Xiong J, Yu X, Yu S, Bai B, Xu H, Ji H, Teliewubai J, Wang K, Chi C, Lu Y, Zhou Y, Fan X, Li J, Zhang Y, Xu Y. Comparison of central and peripheral hemodynamics in association with left ventricular diastolic dysfunction in the community-based elderly Chinese. J Am Soc Hypertens. 2017 Jun;11(6):366-375. doi: 10.1016/j.jash.2017.04.009. Epub 2017 Apr 27.

    PMID: 28528875DERIVED

  • Ji H, Xiong J, Yu S, Chi C, Fan X, Bai B, Zhou Y, Teliewubai J, Lu Y, Xu H, Zhang Y, Xu Y. Northern Shanghai Study: cardiovascular risk and its associated factors in the Chinese elderly-a study protocol of a prospective study design. BMJ Open. 2017 Mar 29;7(3):e013880. doi: 10.1136/bmjopen-2016-013880.

    PMID: 28360242DERIVED

  • Lu Y, Zhu M, Bai B, Chi C, Yu S, Teliewubai J, Xu H, Wang K, Xiong J, Zhou Y, Ji H, Fan X, Yu X, Li J, Blacher J, Zhang Y, Xu Y. Comparison of Carotid-Femoral and Brachial-Ankle Pulse-Wave Velocity in Association With Target Organ Damage in the Community-Dwelling Elderly Chinese: The Northern Shanghai Study. J Am Heart Assoc. 2017 Feb 20;6(2):e004168. doi: 10.1161/JAHA.116.004168.

    PMID: 28219916DERIVED

Biospecimen

Retention: SAMPLES WITH DNA

Pasting venous blood sample and urine sample were collected for each participant.

Study Design

Study Type
observational
Observational Model
ECOLOGIC OR COMMUNITY
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor in medicine, clinical chief

Study Record Dates

First Submitted

February 15, 2015

First Posted

February 23, 2015

Study Start

August 1, 2014

Primary Completion

September 1, 2017

Last Updated

February 23, 2015

Record last verified: 2015-02