Independent and Combined Effects of Aerobic and Resistance Training on Blood Pressure

NCT03734146 | Completed

• 1 other identifier: 14-330
• Study Type: interventional
• Target: 69
• Locations: 0 countries
• Sites: N/A

Brief Summary

We compared the effects of 8 weeks of aerobic exercise only, resistance exercise only, or a combination of both on blood pressure in overweight or obese middle-aged adults with elevated blood pressure. Participants engaged in supervised exercise sessions 3 times per week for 60 minutes each session. Outcomes were assessed at baseline and after the 8-week intervention. Extra-intervention physical activity and diet were also assessed.

Conditions

Cardiovascular Risk Factor

Outcome Measures

Primary Outcomes (1)

• Change in resting blood pressure

  resting systolic and diastolic blood pressure

  Immediately before and after the 8 week intervention

Study Arms (4)

Aerobic exercise (AE)

EXPERIMENTAL

Engage in supervised aerobic exercise for 60 minutes on 3 days per week for 8 weeks. Exercise is performed on a recumbent bike or treadmill at 50-80% of their heart rate reserve.

Behavioral: Aerobic Exercise

Resistance exercise (RE)

EXPERIMENTAL

Engage in supervised resistance exercise for 60 minutes on 3 days per week for 8 weeks. Exercise consists of 3 sets of 8-12 repetitions of 12 exercises for the major muscle groups.

Behavioral: Resistance Exercise

Combined Resistance and Aerobic Exercise

EXPERIMENTAL

Engage in supervised aerobic resistance exercise for 60 minutes on 3 days per week for 8 weeks. Exercise consists of 30 min aerobic exercise at 50-80% heart rate reserve and 30 min of resistance exercise comprising 2 sets of 8-12 repetitions of 9 exercises for the major muscle groups.

Behavioral: Combined aerobic and resistance exercise

No training control

NO INTERVENTION

No exercise training. Participants will refrain from any moderate-vigorous exercise or resistance training for 8 weeks.

Interventions

Aerobic Exercise BEHAVIORAL

180 minutes of moderate-vigorous intensity aerobic exercise per week

Aerobic exercise (AE)

Resistance Exercise BEHAVIORAL

180 minutes of resistance exercise per week

Resistance exercise (RE)

Combined aerobic and resistance exercise BEHAVIORAL

180 minutes of exercise per week with 90 minutes per week coming from moderate-vigorous intensity aerobic exercise and 90 minutes per week coming from resistance exercise

Combined Resistance and Aerobic Exercise

Eligibility Criteria

• Age: 45 Years - 74 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Systolic/diastolic blood pressure of 120-159/80-99 mm Hg
• Non-smoking
• Overweight or obese, with a body mass index of 25-40 kg/m2
• Inactive--not meeting the aerobic or resistance physical activity guidelines, which means engaging in less than 150 minutes/wk of moderate intensity aerobic exercise and less than 2 days per week of resistance training over the past 3 months.

You may not qualify if:

• Unstable coronary heart disease or decompensated heart failure
• Severe pulmonary hypertension or aortic stenosis
• Acute myocarditis, endocarditis, pericarditis, or aortic dissection
• Other medical condition that is life-threatening or that can interfere or be aggravated by the exercise training such as cancer, uncontrolled diabetes, severe pain or mobility limitations.
• Premenopausal women or postmenopausal women taking hormonal replacement therapy
• Pregnant women or anticipated pregnancy via IVF or other medical procedures during the course of the intervention

Sponsors & Collaborators

• Iowa State University: lead

MeSH Terms

Interventions

Exercise; Resistance Training

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena; Exercise Therapy; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Physical Therapy Modalities; Physical Conditioning, Human

Study Officials

• Duck-chul Lee, PhD

  Iowa State University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Masking Details: The outcomes assessor was blinded to treatment group allocation.
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: randomized controlled trial

Study Record Dates

• First Submitted: October 31, 2018
• First Posted: November 7, 2018
• Study Start: July 15, 2014
• Primary Completion: December 19, 2014
• Study Completion: December 19, 2014
• Last Updated: November 7, 2018

Record last verified: 2018-10

Data Sharing

• IPD Sharing: Will not share