NCT03272945|Completed
Linked-color Imaging for the Detection of Colorectal Flat Lesions
Linked-color Imaging Versus White Light for the Detection of Colorectal Flat Lesions: a Randomized, Controlled Trial
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Linked-color Imaging Versus White Light for the Detection of Colorectal Flat Lesions: a Randomized, Controlled Trial
Sponsor study identifier
interventional
400
1 country
1
Study Start
September 6, 2017
Actual (reported)Primary Completion
December 31, 2018
Actual (reported)Study Completion
December 31, 2018
Actual (reported)Linked color imaging (LCI) was recently developed and uses a laser endoscopic system (Fujifilm Co, Tokyo, Japan) that acquires images by simultaneously using narrow-band short-wavelength light and white-light (WL) in an appropriate balance. LCI is a new image-enhancing technology that is intended to enhance slight color differences in the red region of the mucosa. The acquired color information is reallocated to differentiate colors that are similar to the mucosal color, resulting in improved performance in depicting blood vessels, and additional image processing that enhances color separation for red color permits clear visualization of red blood vessels and white pits. This modality may increase the detection rate of colorectal polyps by enhancing the visibility of colonic mucosal vessels. In addition, it has been reported that LCI increases the visibility of colorectal flat lesions and contributes to improvement of the detection rate for these lesions. The primary aim of the current study was to compare the detection rate of colorectal flat lesions of LCI cap-assisted colonoscopy with WL cap-assisted colonoscopy in prospective randomized trial. In addition, we prospectively compared LCI and WL with regard to the visibility of colorectal flat lesions found in this study.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
December 31, 2018
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
September 2, 2017
Actual (reported)September 6, 2017
Actual (reported)September 6, 2017
Actual (reported)December 31, 2018
Actual (reported)December 31, 2018
Actual (reported)Average prevalence of flat lesion /patient detected
The total number of flat colorectal lesion/patient was defined. The average prevalence of flat lesion /patient detected was calculated.
procedure
Adenoma detection rate
procedure
Polyp detection rate
procedure
The visibility of colorectal flat lesions
1 day
Once the randomization assignment was announced, the whole colonoscopy from insertion to cecum to withdrawal of endoscope was carried out entirely by using Linked-color imaging (LCI).
Once the randomization assignment was announced, the whole colonoscopy from insertion to cecum to withdrawal of endoscope was carried out entirely by using white light (WL).
Linked-color imaging colonoscopy
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Showa Inan General hospital
Komagane, Nagano, 399-4191, Japan
Kudo T, Horiuchi A, Kyodo R, Horiuchi I, Arai N, Kajiyama M, Tanaka N. Linked colour imaging versus white-light colonoscopy for the detection of flat colorectal lesions: A randomized controlled trial. Colorectal Dis. 2021 Jun;23(6):1414-1420. doi: 10.1111/codi.15605. Epub 2021 Mar 16.
Akira Horiuchi, MD
Showa Inan General Hospital
400 participants (actual enrollment reported by the registry).
First Submitted
September 2, 2017
First Posted
September 6, 2017
Study Start
September 6, 2017
Actual (reported)Contact the study team to confirm eligibility.
Primary Completion
December 31, 2018
Actual (reported)Study Completion
December 31, 2018
Actual (reported)Last Updated
January 8, 2019
Record last verified: 2019-01
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Source: ClinicalTrials.gov.
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