Simultaneous Injection of Propofol and Rocuronium in Inducing General Anesthesia

NCT03270696 | Completed

• 1 other identifier: JHSeo_MV
• Study Type: interventional
• Target: 114
• Locations: 1 country
• Sites: 1

Brief Summary

This study is conducted to evaluate the efficacy of simultaneous injection of propofol and rocuronium in inducing general anesthesia.

Conditions

Anesthesia; Functional

Outcome Measures

Primary Outcomes (1)

• mean tidal volume

  mean tidal volume of facemask ventilation in 1 minute

  from starting facemask ventilation for 1 minute

Study Arms (2)

simultaneous administration of propofol and rocuronium

EXPERIMENTAL

In this group, the investigator will administrate propofol (2ml/kg) and rocuronium (0.6mg/kg) simultaneously, and start facemask ventilation after patient loss consciousness to induce general anesthesia. The investigator will measure the mean tidal volume (TV) applied during facemask ventilation for 1 minute.

Drug: administration of propofol and rocuronium

ordinal administration of propofol and rocuronium

EXPERIMENTAL

In this group, the investigator will administrate propofol (2ml/kg) first, and follow injection of rocuronium (0.6mg/kg) after patient loss consciousness and confirming facemask ventilation. The investigator will measure the mean tidal volume (TV) applied during facemask ventilation for 1 minute.

Drug: administration of propofol and rocuronium

Interventions

administration of propofol and rocuronium DRUG

compare the tidal volume applied from starting facemask ventilation under 15cmH2O of PCV for 1 minute according to administrating propofol and rocuronium simultaneously, or ordinally

ordinal administration of propofol and rocuronium; simultaneous administration of propofol and rocuronium

Eligibility Criteria

• Age: 20 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• patients undergoing elective surgery requiring endotracheal intubation
• ASA I, II, and III
• above 20 years

You may not qualify if:

• refuse to enroll
• patients with risk of aspirating gastric contents
• patients in whom NMBs are contraindicated
• patients with predictors of difficult mask ventilation

Sponsors & Collaborators

• Seoul National University Hospital: lead

Study Sites (1)

Seoul National University Hospital

Seoul, South Korea

Location

Related Publications (1)

• Min SH, Im H, Kim BR, Yoon S, Bahk JH, Seo JH. Randomized Trial Comparing Early and Late Administration of Rocuronium Before and After Checking Mask Ventilation in Patients With Normal Airways. Anesth Analg. 2019 Aug;129(2):380-386. doi: 10.1213/ANE.0000000000004060.

  PMID: 30768462 DERIVED

MeSH Terms

Interventions

Rocuronium

Intervention Hierarchy (Ancestors)

Androstanols; Androstanes; Steroids; Fused-Ring Compounds; Polycyclic Compounds

Study Officials

• JH Seo

  Seoul National University Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, CARE PROVIDER
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: August 23, 2017
• First Posted: September 1, 2017
• Study Start: August 23, 2017
• Primary Completion: January 30, 2018
• Study Completion: January 30, 2018
• Last Updated: April 12, 2018

Record last verified: 2017-09

Locations

KR (1)