A Neurofeedback Intervention to Improve Working Memory in Schizophrenia
Enhancing Gamma Band Response in Schizophrenia to Improve Working
1 other identifier
interventional
64
1 country
1
Brief Summary
Schizophrenia affects 2.4 million Americans and causes significant individual and societal costs. Cognitive deficits including poor working memory arise early in the course of illness, account for poor long-term outcomes and have been difficult to treat with available treatments. The investigators are proposing to develop a novel, computer-based brain training to improve working memory in schizophrenia patients, which, if successful could have significant personal, societal, and economic impact.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable schizophrenia
Started Mar 2018
Longer than P75 for not_applicable schizophrenia
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
August 17, 2017
CompletedFirst Posted
Study publicly available on registry
August 24, 2017
CompletedStudy Start
First participant enrolled
March 1, 2018
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 1, 2024
CompletedStudy Completion
Last participant's last visit for all outcomes
April 1, 2024
CompletedJune 4, 2024
May 1, 2024
6.1 years
August 17, 2017
May 31, 2024
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Change in Task related Gamma band response (gamma coherence and power)
Gamma-NFBs effects on gamma coherence and gamma power over time will be assessed.
This variable will be assessed at t=0, 4 weeks, 8 weeks, 12 weeks and 4 weeks post completion of intervention
Secondary Outcomes (1)
Change in Working memory
This variable will be assessed at t=0, 12 weeks, and 4 weeks post study completion.
Study Arms (1)
Schizophrenia patients
EXPERIMENTALThirty SCZ patients will receive neurofeedback to enhance gamma band response in an open-label, proof of concept study.
Interventions
Neurofeedback (NFB) will be administered to improve gamma band response. NFBs effects will be measured on gamma coherence and working memory.
Eligibility Criteria
You may qualify if:
- Diagnosis of schizophrenia/schizoaffective disorder
You may not qualify if:
- Active substance use disorders in the last 30 days
- Medication changes in the last 30 days
- History of traumatic brain injury
- seizure disorder
- pregnancy
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
University of California at San Diego
La Jolla, California, 92093, United States
Related Publications (1)
Lin Y, Shu IW, Hsu SH, Pineda JA, Granholm EL, Singh F. Novel EEG-Based Neurofeedback System Targeting Frontal Gamma Activity of Schizophrenia Patients to Improve Working Memory. Annu Int Conf IEEE Eng Med Biol Soc. 2022 Jul;2022:4031-4035. doi: 10.1109/EMBC48229.2022.9870878.
PMID: 36085679DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Assistant Clinical Professor
Study Record Dates
First Submitted
August 17, 2017
First Posted
August 24, 2017
Study Start
March 1, 2018
Primary Completion
April 1, 2024
Study Completion
April 1, 2024
Last Updated
June 4, 2024
Record last verified: 2024-05
Data Sharing
- IPD Sharing
- Will not share