An Intermediate Access Protocol for Selumetinib for Treatment of Neurofibromatosis Type 1

NCT03259633 | Unknown

• 1 other identifier: D1346R00002
• Study Type: expanded_access
• Target: N/A
• Locations: 1 country
• Sites: 1

Brief Summary

This will be an open-label, single-arm, multicenter intermediate access protocol which provides treatment access to selumetinib for eligible patients with neurofibromatosis type 1 (NF1) who have inoperable, progressive/symptomatic plexiform neurofibromas (PN) without any alternative therapeutic options. All patients will continue to receive drug while they are deriving clinical benefit. Approximately 100 patients in the US will be treated as part of this protocol

Conditions

NF type1 With Inoperable Plexiform Neurofibromas

Keywords

Neurofibromatosis type1,; Plexiform Neurofibromas; inoperable, progressive/symptomatic plexiform neurofibromas (PN) without any alternative therapeutic options; mutation in the NF1 gene; Selumetinib; Early Access; Intermediate Access Protocol

Interventions

Selumetinib DRUG

open-label, single-arm, multicenter intermediate access protocol

Eligibility Criteria

• Age: 2 Years - 130 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Diagnosis of neurofibromatosis type 1 (NF1) and have inoperable, progressive/symptomatic plexiform neurofibromas (PN)
• Presence of inoperable PN , defined as a PN that cannot be surgically completely removed without risk for substantial morbidity
• Patients aged ≥2 with onset of disease before they were 18 years and a BSA ≥ 0.55 m2 who are able to swallow whole capsules. (approx. length 15.4 mm, diameter 5.4 mm). A swallow test must be performed before requesting drug
• Normal cardiac function defined as normal ejection fraction (ECHO, MUGA or cardiac MRI) as per institutional normal and absence of prior heart disease
• Adequate blood pressure as defined in line with local practice.
• The patient has exhausted all available approved therapies as appropriate for NF1 with inoperable progressive/symptomatic PN
• Provision of a signed informed consent prior to any protocol specific procedures. Patients already receiving selumetinib through single patient access who enroll in this protocol must be reconsented and sign the consent form for this intermediate access protocol.
• For female patients of childbearing potential, have evidence of a post-menopausal status, or a negative urinary or serum pregnancy test.

You may not qualify if:

• Unresolved chronic toxicity ≥ CTCAE Grade 2 from previous therapy
• Patients eligible for any ongoing clinical trials with selumetinib in the indication in question
• Ophthalmological conditions: Current or past history of retinal pigment epithelial detachment (RPED)/central serous retinopathy (CSR) or retinal vein occlusion Intraocular pressure (IOP) should not be \> 21 mmHg for adults or outside the range of normal for children or uncontrolled glaucoma (irrespective of IOP)
• Male or female patients of reproductive potential and, as judged by the investigator, are not employing an effective method of birth control.
• Female patients who are breast-feeding.
• Have evidence of any other significant clinical disorder or laboratory finding that, as judged by the treating physician, makes it undesirable for the patient to participate in the study.
• Have any evidence of a severe or uncontrolled systemic disease (e.g. unstable or uncompensated respiratory, cardiac, hepatic, or renal disease, active infection (including hepatitis B, hepatitis C, HIV), active bleeding diatheses or renal transplant
• Have refractory nausea and vomiting, chronic gastrointestinal diseases (e.g., inflammatory bowel disease), or significant bowel resection that would adversely affect the absorption / bioavailability of the orally administered study medication

Sponsors & Collaborators

• AstraZeneca: lead

Study Sites (1)

Research Site

New Orleans, Louisiana, 12345, United States

Location

MeSH Terms

Conditions

Neurofibroma, Plexiform

Interventions

AZD 6244

Condition Hierarchy (Ancestors)

Neurofibroma; Nerve Sheath Neoplasms; Neoplasms, Nerve Tissue; Neoplasms by Histologic Type; Neoplasms; Peripheral Nervous System Neoplasms; Nervous System Neoplasms; Nervous System Diseases; Peripheral Nervous System Diseases; Neuromuscular Diseases

Study Officials

• Miriam Bornhorst, MD

  Investigator

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: expanded access
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 21, 2017
• First Posted: August 24, 2017
• Last Updated: May 1, 2020

Record last verified: 2020-04

Locations

US (1)