Success Metrics

Clinical Success Rate
79.2%

Based on 38 completed trials

Completion Rate
79%(38/48)
Active Trials
16(22%)
Results Posted
76%(29 trials)
Terminated
10(14%)

Phase Distribution

Ph phase_2
37
51%
Ph phase_3
3
4%
Ph phase_1
32
44%

Phase Distribution

32

Early Stage

37

Mid Stage

3

Late Stage

Phase Distribution72 total trials
Phase 1Safety & dosage
32(44.4%)
Phase 2Efficacy & side effects
37(51.4%)
Phase 3Large-scale testing
3(4.2%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

74.5%

38 of 51 finished

Non-Completion Rate

25.5%

13 ended early

Currently Active

16

trials recruiting

Total Trials

73

all time

Status Distribution
Active(20)
Completed(38)
Terminated(13)
Other(2)

Detailed Status

Completed38
Active, not recruiting13
Terminated10
Not yet recruiting4
Recruiting3
Withdrawn3

Development Timeline

Analytics

Development Status

Total Trials
73
Active
16
Success Rate
79.2%
Most Advanced
Phase 3

Trials by Phase

Phase 132 (44.4%)
Phase 237 (51.4%)
Phase 33 (4.2%)

Trials by Status

recruiting34%
terminated1014%
unknown23%
withdrawn34%
completed3852%
active_not_recruiting1318%
not_yet_recruiting45%

Recent Activity

Clinical Trials (73)

Showing 20 of 73 trialsScroll for more
NCT02664935Phase 2

National Lung Matrix Trial: Multi-drug Phase II Trial in Non-Small Cell Lung Cancer

Completed
NCT03162627Phase 1

Selumetinib and Olaparib in Solid Tumors

Active Not Recruiting
NCT01089101Phase 1

Selumetinib in Treating Young Patients With Recurrent or Refractory Low Grade Glioma

Active Not Recruiting
NCT01364051Phase 1

Cediranib Maleate and Selumetinib Sulfate in Treating Patients With Solid Malignancies

Active Not Recruiting
NCT04924608Phase 3

Efficacy and Safety of Selumetinib in Adults With NF1 Who Have Symptomatic, Inoperable Plexiform Neurofibromas

Active Not Recruiting
NCT06188741Phase 2

Selumetinib for the Prevention of Plexiform Neurofibroma Growth in NF Type 1

Recruiting
NCT02407405Phase 2

MEK 1/2 Inhibitor Selumetinib (AZD6244 Hydrogen Sulfate) in Adults With Neurofibromatosis Type 1 (NF1) and Inoperable Plexiform Neurofibromas

Active Not Recruiting
NCT03801369Phase 2

AMTEC IIT: Phase 2 Multiarm Study in TNBC

Terminated
NCT05101148Phase 1

Phase I Study to Assess the Effect of Food on the PK and Gastrointestinal Tolerability of Selumetinib in Adolescent Children With Neurofibromatosis Type 1 Related Plexiform Neurofibromas

Active Not Recruiting
NCT04590235Phase 1

A Study of Selumetinib in Chinese Paediatric and Adult Subjects With Neurofibromatosis Type 1 (NF1) and Inoperable Plexiform Neurofibromas (PN)

Active Not Recruiting
NCT03392246Phase 2

A Phase 2 Study of Osimertinib in Combination With Selumetinib in EGFR Inhibitor naïve Advanced EGFR Mutant Lung Cancer

Active Not Recruiting
NCT02813135Phase 1

European Proof-of-Concept Therapeutic Stratification Trial of Molecular Anomalies in Relapsed or Refractory Tumors

Recruiting
NCT03326310Phase 1

Selumetinib and Azacitidine in High Risk Chronic Blood Cancers

Recruiting
NCT02546661Phase 1

Open-Label, Randomised, Multi-Drug, Biomarker-Directed, Phase 1b Study in Pts w/ Muscle Invasive Bladder Cancer

Active Not Recruiting
NCT02151084Phase 2

A Study of Different Dosing Schedules of Selumetinib With Cisplatin/Gemcitabine (CIS/GEM) Versus CIS/GEM Alone in Biliary Cancer

Active Not Recruiting
NCT01933932Phase 3

Assess Efficacy & Safety of Selumetinib in Combination With Docetaxel in Patients Receiving 2nd Line Treatment for v-Ki-ras2 Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) Positive NSCLC

Active Not Recruiting
NCT03581487Phase 1

Durvalumab, Tremelimumab, and Selumetinib in Treating Participants With Recurrent or Stage IV Non-small Cell Lung Cancer

Completed
NCT06735820Phase 1

Early Phase Study Evaluating MEK and MDM2 Inhibition in Patients With NF1 and MPNST

Not Yet Recruiting
NCT03095248Phase 2

Trial of Selumetinib in Patients With Neurofibromatosis Type II Related Tumors

Terminated
NCT02188264Phase 1

Selumetinib and Cyclosporine in Treating Patients With Advanced Solid Tumors or Advanced or Metastatic Colorectal Cancer

Completed

Drug Details

Intervention Type
DRUG
Total Trials
73