Cue-Reward Learning and Weight Gain in Youth

NCT03254576 | Completed DMC

• 2 other identifiers: 161468R01DK111106
• Study Type: observational
• Target: 147
• Locations: 1 country
• Sites: 1

Brief Summary

The objective of the study is to compare children at low risk for obesity (two healthy weight parents) to children at high risk for obesity (two overweight parents) in their response rate to food taste and in their rate of learning using fMRI.

Conditions

Overweight; Obesity

Keywords

Overweight; Obesity; Body Mass Index; Weight; Brain imaging; Child; Learning

Outcome Measures

Primary Outcomes (3)

• Cue-reward learning

  Whether rate of the shift in BOLD response from food cue to neutral cue is different between high and low-risk children

  Baseline only

• Reward Sensitivity

  Whether the BOLD response to food cue differs between high and low-risk children

  Baseline only

• Weight gain

  Whether rate of cue reward and reward sensitivity predict weight gain

  Change from baseline at an average of 12 months and 24 months

Study Arms (2)

Children at high-risk for obesity

Healthy-weight children (5th-75thBMI%) with two overweight/obese parents (BMI\>25)

Other: Functional MRI

Children at low-risk for obesity

Healthy-weight children (5th-75thBMI%) with two healthy-weight parents (BMI = 18-24.9)

Other: Functional MRI

Interventions

Functional MRI OTHER

Children at high-risk for obesity; Children at low-risk for obesity

Eligibility Criteria

• Age: 8 Years - 11 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)
• Sampling Method: Non-Probability Sample

Study Population

Healthy-weight children (5-75thBMI%) between the ages of 8 and 11 years old with either two over-weight parents (BMI\>25) or two healthy-weight parents (BMI = 18-24.9)

You may qualify if:

• Healthy weight children between the ages of 8 and 11 Years
• BMI 5-75th percentile
• Child must be right-handed
• Child must be willing to participate in an fMRI scan
• Either two biological parents who are overweight/obese or no biological parents that are overweight/obese
• One biological parent willing to bring child to assessment visits
• Child and participating parent Fluent in English for speaking, reading, and writing
• Child must like cheese pizza and chocolate milkshake

You may not qualify if:

• Child overweight (BMI≥85th percentile)
• Child diagnoses of a serious chronic physical disease (e.g., diabetes) for which physician supervision of diet and exercise prescription are needed
• Child who is taking medications that may impact brain responses (can take kids who are stable on meds)
• Child with MRI contraindications (presence of metallic foreign object or device in body, piercings that cannot be removed, tattooed permanent makeup that contain metal, braces, head trauma, claustrophobia, use of Bigen permanent hair dye)
• Child with an active eating disorder (reported on EDE interview) or with first degree relative with Anorexia Nervosa or Bulimia Nervosa
• Cognitive impairment or disability determined through parent and child self-report measures, and parent reported child individual education plan
• Vision problems uncorrectable with lenses
• Food allergies related to cheese pizza, chocolate milkshake, or the snack foods used in the study
• Menarche in female participants at time of enrollment
• Children scoring within the midpubertal range or higher based on the Pubertal Development Scale

Sponsors & Collaborators

• University of California, San Diego: lead
• National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK): collaborator
• National Institutes of Health (NIH): collaborator

Study Sites (1)

UCSD Center for Healthy Eating and Activity Research (CHEAR)

La Jolla, California, 92093, United States

Location

Related Publications (2)

• Boutelle KN, Wierenga CE, Bischoff-Grethe A, Melrose AJ, Grenesko-Stevens E, Paulus MP, Kaye WH. Increased brain response to appetitive tastes in the insula and amygdala in obese compared with healthy weight children when sated. Int J Obes (Lond). 2015 Apr;39(4):620-8. doi: 10.1038/ijo.2014.206. Epub 2014 Dec 11.

  PMID: 25582522 BACKGROUND

• Mestre ZL, Bischoff-Grethe A, Eichen DM, Wierenga CE, Strong D, Boutelle KN. Hippocampal atrophy and altered brain responses to pleasant tastes among obese compared with healthy weight children. Int J Obes (Lond). 2017 Oct;41(10):1496-1502. doi: 10.1038/ijo.2017.130. Epub 2017 Jun 2.

  PMID: 28572588 BACKGROUND

MeSH Terms

Conditions

Overweight; Obesity; Body Weight

Condition Hierarchy (Ancestors)

Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Kerri Boutelle, Ph.D.

  UCSD

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: August 16, 2017
• First Posted: August 18, 2017
• Study Start: December 1, 2016
• Primary Completion: December 27, 2023
• Study Completion: December 27, 2023
• Last Updated: January 29, 2024

Record last verified: 2024-01

Locations

US (1)