Effects of Action Observation Therapy on Pain, Functional Level and Brain Hemodynamic in Patients With Knee Osteoarthritis

NCT03245073 | Completed

• 1 other identifier: ATADEK-2017/8
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

In this project, investigators aim to investigate the effects of action observation therapy on pain, fear of movement, functional level and brain hemodynamics in patients with knee osteoarthritis. The study is unique in that this method, which has already been used for post-surgical or motor healing, aims at long-term administration for the first time with chronic pain and objective visualization of the results. This study will create a new perspective to understand the physiology of pain, which has attracted much interest in the literature in recent years, and will shed light on the studies that can be done in this regard. Participants' joint range of motion in the initial assessments will be measured by electro-goniometer, muscle strength assessment by JTech hand dynamometer at appropriate evaluation positions. In assessing pain, pain levels at rest and during activity will be questioned using Visual Analog Scale. Fear of movement of individuals will be assessed via Tampa Kinesiophobia Scale and functional levels will be assessed via Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and the Timed Up and Go Test. Functional near infrared spectroscopy (fNIRS) will be used for evaluation of brain hemodynamics. The first group, will receive exercises with action observation therapy; and the second group will receive only exercises. The exercise programme will be administered under physiotherapist supervision for three days a week for six weeks. The evaluations will be repeated at the beginning of the study and at the end of the sixth week. Data obtained from the study will be analyzed using appropriate statistical methods.

Conditions

Pain, Chronic; Osteoarthritis, Knee

Outcome Measures

Primary Outcomes (3)

• Brain Hemodynamics

  Functional near infrared spectroscopy will be used to assess the brain hemodynamics during the observation of actions, motor imagery and active movement.

  6 weeks

• Pressure pain threshold

  Algometer (dolorimeter) will be used to assess the pressure pain threshold.

  6 weeks

• Visual Analog Scale

  Self reported pain intensity during rest and walking measured by 0-10 point scale.

  6 weeks

Other Outcomes (3)

• Western Ontario and Mcmaster Universities Osteoarthritis Index

  6 weeks

• Kinesiophobia

  6 weeks

• Pain Catastrophization

  6 weeks

Study Arms (2)

Exercise

ACTIVE COMPARATOR

Strengthening and stretching exercises for hip and knee muscles, balance and proprioceptive exercises

Other: Exercise

Action observation therapy and exercise

EXPERIMENTAL

Video of normal human movement and Strengthening and stretching exercises for hip and knee muscles

Other: Action observation therapy; Other: Exercise

Interventions

Action observation therapy OTHER

The normal human movement will be recorded and than the patients will be watched them.

Action observation therapy and exercise

Exercise OTHER

Strengthening and stretching exercise programme focuses on hip and knee muscles

Action observation therapy and exercise; Exercise

Eligibility Criteria

• Age: 45 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Between 45 to 70 years;
• Unilateral knee osteoarthritis according to clinical and radiological criteria
• Grade 2 or Grade 3 according to Kellgren-Lawrance Scale
• Right-handed according to Edinburgh Handedness Scale
• Chronic pain during the rest or activity above 4 points according to the Verbal Rating Scale

You may not qualify if:

• Having neurological or psychiatric diseases
• Having chronic pain due to another pain disorder
• Having rheumatic diseases
• Using antidepressant medications or opioids
• Knee surgery within one year prior to the study
• Intraarticular injection and attend physical therapy within 6 months prior to the study
• Mini Mental State Examination Scale score below 24

Sponsors & Collaborators

• Acibadem University: lead

Study Sites (1)

Haydarpasa Numune Training and Research Hospital

Istanbul, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Chronic Pain; Osteoarthritis, Knee

Interventions

Exercise

Condition Hierarchy (Ancestors)

Pain; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Osteoarthritis; Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Doctor

Study Record Dates

• First Submitted: July 20, 2017
• First Posted: August 10, 2017
• Study Start: September 15, 2017
• Primary Completion: May 15, 2019
• Study Completion: May 18, 2019
• Last Updated: February 11, 2020

Record last verified: 2020-02

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)