Muscle Property, Alignment and Joint Loading in People With Knee Osteoarthritis

NCT03628508 | Completed Results

• 1 other identifier: HSEARS20170406003
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

Knee osteoarthritis (KOA) is a common chronic painful musculoskeletal condition among older adults. It poses great challenge to the health care system due to its inability to be cured. Understanding factors associated with disease progression in KOA should assist the development of novel prevention/rehabilitation strategies. This study investigate factors including muscle properties, lower limb alignment and joint loading in patients with knee osteoarthritis before and after a six-week exercise program.

Conditions

Osteoarthritis, Knee

Keywords

muscle tension; alignment; knee osteoarthritis; loading

Outcome Measures

Primary Outcomes (1)

• Change of External Knee Adduction Moment as Assessed by Visual Motion Analysis System

  External knee moment in the frontal plane during early stance phase of walking

  At baseline and one week after intervention

Secondary Outcomes (3)

• Change of Pain Severity Score as Assessed by Knee Injury and Osteoarthritis Outcome Score

  At baseline and one week after intervention

• Tibial Torsion as Assessed by X-ray Imaging

  At baseline

• Change of Young's Modulus of Quadriceps as Assessed by Ultrasound Elastography

  At baseline and one week after intervention

Study Arms (1)

Exercise

EXPERIMENTAL

Six-week exercise including stretching, strengthening, endurance and gait modification

Other: Exercise

Interventions

Exercise OTHER

Comprehensive exercise program including strengthening, stretching, gait modification etc.

Exercise

Eligibility Criteria

• Age: 50 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age between 50-80
• having radiographic tibiofemoral joint OA in the medial compartment defined as Kellgren and Lawrence grade = 2 to 3
• having medial knee pain on most days of the month
• having a minimum average pain score of 2 on an 11-point numerical rating scale in the past week while walking

You may not qualify if:

• having lateral tibiofemoral compartment osteophytes greater than the medial side.
• having undergone intra-articular corticosteroid injection or knee surgery to either knee within the past 3 months
• having a systemic arthritic condition (e.g., rheumatoid arthritis)
• having a knee joint replacement or high tibial osteotomy in the past
• having any other muscular, joint or neurological condition influencing lower limb function
• unable to walk unaided
• having low back, hip, ankle or foot pain \> 3 on numerical rating scale
• having a body mass index (BMI) \>36 kg/ m2

Sponsors & Collaborators

• The Hong Kong Polytechnic University: lead
• Queen Mary Hospital, Hong Kong: collaborator

Study Sites (1)

Queen Mary Hospital

Hong Kong, Hong Kong

Location

MeSH Terms

Conditions

Osteoarthritis, Knee

Interventions

Exercise

Condition Hierarchy (Ancestors)

Osteoarthritis; Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Results Point of Contact

• Title: Dr Amy Fu
• Organization: The Hong Kong Polytechnic University

amy.fu@polyu.edu.hk

8522766 6726

Study Officials

• Siu Ngor Fu, PhD

  The Hong Kong Polytechnic University

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: Yes

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 6, 2018
• First Posted: August 14, 2018
• Study Start: March 1, 2017
• Primary Completion: December 31, 2019
• Study Completion: December 31, 2019
• Last Updated: September 16, 2021
• Results First Posted: March 24, 2021

Record last verified: 2018-08

Data Sharing

• IPD Sharing: Will not share

Locations

HK (1)