Meta-Analyses of Low-risk Lifestyle Behaviours and Patient Important Outcomes

NCT03234101 | Unknown

• 1 other identifier: CCS-Low risk lifestyle-2017
• Study Type: observational
• Target: 1
• Locations: 1 country
• Sites: 1

Brief Summary

Public health policy is universal in recommending the adoption of low risk low-risk lifestyle behaviors for health promotion and prevention of chronic or non-communicable diseases (NCDs).These behaviors generally include achieving and maintaining a healthy body weight, healthy diet, regular physical activity, smoking cessation, moderate alcohol intake, and adequate sleep. While there is a general consensus that adherence to any one of these low-risk lifestyle behaviors is associated with benefit, it is not clear if adherence to multiple behaviors would result in a larger benefit across different groups of people, conditions, and chronic disease outcomes. The Canadian Cardiovascular Society (CCS), as part of the Dyslipidemia Guidelines Update, commissioned a series of systematic reviews and meta-analyses (a type of knowledge synthesis) using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach to quantify the benefit of adherence to multiple low-risk lifestyle behaviors in relation to patient-important chronic disease outcomes (risk of cardiovascular disease, diabetes, cancer, and death) and assesses the quality and strength of the evidence for this benefit.

Conditions

Cardiovascular Disease; Diabetes; Cancer; Mortality

Keywords

Systematic review and meta-analysis; Evidence-based medicine (EBM); Evidence-based nutrition (EBN); Clinical practice guidelines; Prospective cohort studies; Low-risk lifestyle behaviours; Healthy Diet; Exercise; Physical activity; Body weight; Sleep; alcohol; Smoking; Cardiovascular disease; Coronary heart disease; Stroke; Diabetes; Cancer; Cardiovascular disease mortality; Coronary heart disease mortality; Stroke mortality; All-cause mortality

Outcome Measures

Primary Outcomes (4)

• Cardiovascular disease

  Cardiovascular disease incidence and mortality, coronary heart disease incidence and mortality, stroke incidence and mortality

  Up to 20 years

• Diabetes

  Diabetes incidence

  Up to 20 years

• Cancer

  Cancer incidence and mortality

  Up to 20 years

• All-cause mortality

  Up to 20 years

Interventions

Low-risk lifestyle behaviours BEHAVIORAL

Low-risk lifestyle behaviours defined as: 1\) Healthy body weight (Minimum: BMI \<30kg/m2 or WC of \<88 in females or \<92 in males); 2) Healthy diet (healthy diet, diet score with higher fruits \& vegetables to Mediterranean dietary pattern); 3) Regular physical activity (20 minutes ≥ 1 time/week ); 4) Smoking cessation (never smoked to smoking cessation \>12 months); 5) Moderate alcohol intake (up to 30g/day); 6) Adequate sleep (\>6 hours)

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

All individuals, both children and adults, regardless of health status.

You may qualify if:

• Prospective cohort studies or case-cohort studies
• Duration \>= 1 year
• Assessment of exposures of adherence to at-least three low-risk lifestyle behaviors, one of which must include a healthy diet
• Ascertainment of clinical outcome data for cardiovascular disease, diabetes, cancer, or all-cause mortality by level of exposure

You may not qualify if:

• Ecological, cross-sectional, and retrospective observational studies, clinical trials, and non-human studies
• Duration \< 1 year
• No viable exposures data
• No viable clinical outcome data

Sponsors & Collaborators

• University of Toronto: lead
• Canadian Institutes of Health Research (CIHR): collaborator
• The Physicians' Services Incorporated Foundation: collaborator
• Canadian Diabetes Association: collaborator
• Canadian Cardiovascular Society: collaborator
• Banting & Best Diabetes Centre: collaborator

Study Sites (1)

The Toronto 3D (Diet, Digestive tract and Disease) Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital

Toronto, Ontario, M5C 2T2, Canada

Location

Related Publications (12)

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  PMID: 10882764 BACKGROUND

• Sumamo E, Ha C, Korownyk C, Vandermeer B, Dryden DM. Lifestyle Interventions for Four Conditions: Type 2 Diabetes, Metabolic Syndrome, Breast Cancer, and Prostate Cancer [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2011 May 26. Available from http://www.ncbi.nlm.nih.gov/books/NBK254022/

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• Hu FB, Manson JE, Stampfer MJ, Colditz G, Liu S, Solomon CG, Willett WC. Diet, lifestyle, and the risk of type 2 diabetes mellitus in women. N Engl J Med. 2001 Sep 13;345(11):790-7. doi: 10.1056/NEJMoa010492.

  PMID: 11556298 BACKGROUND

• Loef M, Walach H. The combined effects of healthy lifestyle behaviors on all cause mortality: a systematic review and meta-analysis. Prev Med. 2012 Sep;55(3):163-70. doi: 10.1016/j.ypmed.2012.06.017. Epub 2012 Jun 24.

  PMID: 22735042 BACKGROUND

• Mozaffarian D, Afshin A, Benowitz NL, Bittner V, Daniels SR, Franch HA, Jacobs DR Jr, Kraus WE, Kris-Etherton PM, Krummel DA, Popkin BM, Whitsel LP, Zakai NA; American Heart Association Council on Epidemiology and Prevention, Council on Nutrition, Physical Activity and Metabolism, Council on Clinical Cardiology, Council on Cardiovascular Disease in the Young, Council on the Kidney in Cardiovasc. Population approaches to improve diet, physical activity, and smoking habits: a scientific statement from the American Heart Association. Circulation. 2012 Sep 18;126(12):1514-63. doi: 10.1161/CIR.0b013e318260a20b. Epub 2012 Aug 20.

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• Guyatt GH, Oxman AD, Vist GE, Kunz R, Falck-Ytter Y, Alonso-Coello P, Schunemann HJ; GRADE Working Group. GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ. 2008 Apr 26;336(7650):924-6. doi: 10.1136/bmj.39489.470347.AD.

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  PMID: 9310563 BACKGROUND

MeSH Terms

Conditions

Cardiovascular Diseases; Diabetes Mellitus; Neoplasms; Motor Activity; Body Weight; Smoking; Coronary Disease; Stroke

Condition Hierarchy (Ancestors)

Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases; Behavior; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Myocardial Ischemia; Heart Diseases; Vascular Diseases; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases

Study Officials

• JOHN L SIEVENPIPER, MD, PHD, FRCPC

  University of Toronto

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: July 24, 2017
• First Posted: July 31, 2017
• Study Start: June 1, 2016
• Primary Completion: December 1, 2017
• Study Completion: December 1, 2017
• Last Updated: August 3, 2017

Record last verified: 2017-06

Data Sharing

• IPD Sharing: Will not share

Locations

CA (1)