Diagnosis and Prognosis for Aortic Aneurysm aNd Dissection in Anzhen(DPANDA) Study

NCT03233087 | Recruiting

• 1 other identifier: DPANDA
• Study Type: observational
• Target: 1,500
• Locations: 1 country
• Sites: 1

Brief Summary

The registry study aims to determine serial biomarkers to diagnosis and prognosis of aortic aneurysm/aortic dissection.

Conditions

Aortic Aneurysm; Aortic Dissection

Outcome Measures

Primary Outcomes (2)

• Dignosis of each participant

  1. Patients with Aneurysm/Dissection had image information from ultrasound cardiograms and computed tomography to confirm the final diagnosis. 2. AMI if they had chest pain lasting \>20 min, diagnostic serial ECG changes comprising new pathological Q waves or ST-segment and T-wave changes, and a plasma creatine kinase-MB elevation greater than twice the normal level or cardiac troponin I (cTnI) level greater than 0.1 ng/mL. 3. Diagnosis of PE was confirmed by positive spiral computed tomography or pulmonary angiography, a high probability on ventilation perfusion scintigraphy, or a proximal deep vein thrombosis documented on compression ultrasonography or angiography.

  These data is collected from the cases' medical record in an average of 6 month after the sample recruiting

• Prognosis of each participant

  Prognosis information including all-cause mortality and in-hospital mortality.

  These data is collected from the cases' medical record or during follow-up visit at 2-4 years after discharge.

Study Arms (3)

Top third of subjects based levels of selected biomarker.

Middle third of subjects based levels of selected biomarker.

Bottom third ofsubjects based levels of selected biomarker.

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

These cohorts consist of patients who was diagnosed as thoracic aortic aneurysm/dissection or initial suspicion of having thoracic aortic aneurysm/dissection.

You may qualify if:

• Retrospective
• All patients who were referred to the surgical service for evaluation and management of aortic dissection were included.
• Perspective
• Patients with initial suspicion of having AAD were perspectively enrolled.

You may not qualify if:

• Retrospective
• Patients who received packed red blood cells, whole blood, or platelets less than 10 days before the blood sample was taken;
• Patients with aortic trauma, pseudo aneurysm, history of heart failure, renal dysfunction, severe pulmonary diseases, or active cancer;
• Patients who entered the hospital for checkups after surgery.
• Perspective
• Patients in whom there is little or no suspicion of a life-threatening disease;
• Patients with confirmed acute myocardial infarction,angina or pulmonary embolism
• The symptoms were clearly not related to AD (e.g. pleurisy, pneumonia, acute abdominal diseases).

Sponsors & Collaborators

• Beijing Institute of Heart, Lung and Blood Vessel Diseases: lead
• Beijing Luhe Hospital: collaborator
• The First Affiliated Hospital of Dalian Medical University: collaborator
• The First Hospital of Jilin University: collaborator
• First Affiliated Hospital, Sun Yat-Sen University: collaborator
• The General Hospital of Northern Theater Command: collaborator
• The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School: collaborator

Study Sites (1)

Beijing Anzhen Hospital

Beijing, Beijing Municipality, 100029, China

RECRUITING

MeSH Terms

Conditions

Aortic Aneurysm; Aortic Dissection

Condition Hierarchy (Ancestors)

Aneurysm; Vascular Diseases; Cardiovascular Diseases; Aortic Diseases; Dissection, Blood Vessel; Acute Aortic Syndrome

Central Study Contacts

Yuan Wang, PhD

CONTACT

86-010-64456721; wangyuan980510@163.com

Xue Wang, MD

CONTACT

+86 010-64456721; snowlove_@126.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: OTHER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 26, 2017
• First Posted: July 28, 2017
• Study Start: March 1, 2014
• Primary Completion (Estimated): December 31, 2028
• Study Completion (Estimated): December 31, 2028
• Last Updated: June 27, 2024

Record last verified: 2024-06

Locations

CN (1)