NCT06626607

Brief Summary

The goal of this observational study is to learn about the effect of different hypotensive drugs on the prognosis of postoperative aortic patients. The main question it aims to answer is: Does different hypotensive drugs influence the prognosis of postoperative aortic patients? As participants already taking hypotensive drugs as part of their regular medical care, the investigators collect the participants' pre-operation medical record and post-operative follow-up record to evaluate the aorta condition.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
704

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Jan 2017

Longer than P75 for all trials

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2017

Completed
7.4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 30, 2024

Completed
4 months until next milestone

First Submitted

Initial submission to the registry

September 30, 2024

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

September 30, 2024

Completed
4 days until next milestone

First Posted

Study publicly available on registry

October 4, 2024

Completed
Last Updated

October 4, 2024

Status Verified

October 1, 2024

Enrollment Period

7.4 years

First QC Date

September 30, 2024

Last Update Submit

October 2, 2024

Conditions

Aortic AneurysmAortic Dissection

Outcome Measures

Primary Outcomes (1)

  • Aortic diameter

    The maximum diameter of the aorta measured by computed tomography angiography

    Through the study completion, on an average of 3 years

Secondary Outcomes (1)

  • Number of Participants with adverse aortic event

    Through the study completion, on an average of 3 years

Study Arms (2)

CCB group

Patients' postoperative antihypertensive includes CCB (Calcium Calcium Entry Blockers)

Drug: CCB use

non-CCB group

Patients' postoperative antihypertensive does not include CCB

Drug: non-CCB use

Interventions

CCB useDRUG

Postoperative antihypertensive medication includes CCB

CCB group
non-CCB useDRUG

Postoperative antihypertensive medication does not include CCB

non-CCB group

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

From January 1, 2017 to December 1, 2023, 704 patients with hypertention underwent aortic surgery in the institutions. These patients have complete medical records and follow-up data.

You may qualify if:

  • aortic diseases\' patients underwent aortic surgery who require antihypertensive medication.

You may not qualify if:

  • Patients with active vasculitis;
  • Patients allergic to contrast agent
  • Patients with aorta variation

Contact the study team to confirm eligibility.

Sponsors & Collaborators

MeSH Terms

Conditions

Aortic AneurysmAortic Dissection

Condition Hierarchy (Ancestors)

AneurysmVascular DiseasesCardiovascular DiseasesAortic DiseasesDissection, Blood VesselAcute Aortic Syndrome

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
RETROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor

Study Record Dates

First Submitted

September 30, 2024

First Posted

October 4, 2024

Study Start

January 1, 2017

Primary Completion

May 30, 2024

Study Completion

September 30, 2024

Last Updated

October 4, 2024

Record last verified: 2024-10